Yoshino Yuuki

ヨシノユウキ | Yoshino Yuuki

Affiliation and department：
Job title： Researcher
Homepage URL (1)： http://www2.idac.tohoku.ac.jp/dep/cab/

Research field (1)： Human pathology

Research theme for competitive and other funds (19)：

2022 - 2025 中心体異常とDNA損傷によるゲノム不安定性を標的とする新しいがん治療法の開発
2021 - 2024 BRCA1複合体の中心体制御機構の解析による組織特異的発がん機序の解明
2019 - 2022 Development of Targeting therapy for centrosome dysregulation in cancer
2021 - 2022 新規相同組み換え修復活性測定法による乳がん発症リスク診断法の開発
2021 - 2022 BRCA1のリン酸化の時空間的動態の解析

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Papers (34)：

Zhenzhou Fang, Xingming Li, Yuki Yoshino, Natsuko Chiba. Protocol to detect OLA1 polyubiquitination by Aurora A in vivo and in vitro. STAR protocols. 2024. 5. 2. 103008-103008
Motonari T, Yoshino Y, Haruta M, Endo S, Sasaki S, Miyashita M, Tada H, Watanabe G, Kaneko T, Ishida T, et al. Evaluating homologous recombination activity in tissues to predict the risk of hereditary breast and ovarian cancer and olaparib sensitivity. Scientific Reports. 2024. 14. 7519
Yuki Yoshino, Zhenzhou Fang, Natsuko Chiba. The centrosome: a critical hub for cell cycle regulation. Trends in Cell Biology. 2024
Yuki Yoshino, Honami Ogoh, Yudai Iichi, Tomohiro Sasaki, Takahiro Yoshida, Shiori Ichimura, Masahiro Nakayama, Wu Xi, Hiroki Fujita, Megumi Kikuchi, et al. Knockout of Brca1-interacting factor Ola1 in female mice induces tumors with estrogen suppressible centrosome amplification. Biochimica et biophysica acta. Molecular basis of disease. 2024. 167138-167138
Zhenzhou Fang, Xingming Li, Yuki Yoshino, Moe Suzuki, Huicheng Qi, Hinari Murooka, Riko Katakai, Matsuyuki Shirota, Thi Anh Mai Pham, Ayako Matsuzawa, et al. Aurora A polyubiquitinates the BRCA1-interacting protein OLA1 to promote centrosome maturation. Cell reports. 2023. 42. 8. 112850-112850

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MISC (36)：

李星明, 方震宙, 室岡妃南里, 渡邉みのり, 吉野優樹, 森隆弘, 千葉奈津子. BARD1 suppresses the OLA1 polyubiquitination by Aurora A to regulate centrosome maturation. 日本癌学会学術総会抄録集(Web). 2023. 82nd
方震宙, 小林利咲, 蕭澤欽, 吉野優樹, 斉匯成, 千葉奈津子. BRCA1-interacting protein OLA1 promotes DNA damage-induced centrosome amplification through the activation of PLK1. 日本癌学会学術総会抄録集(Web). 2023. 82nd
吉野優樹, 方震宙, 千葉奈津子. BRCA1-associated protein RACK1 regulates centrosome duplication in breast cancer cells. 日本癌学会学術総会抄録集(Web). 2023. 82nd
Natsuko Chiba, Megumi Kikuchi, Zhenzhou Fang, Takato Goto, Yuki Yoshino, Chikashi Ishioka, Huicheng Qi. BRCA1 transports DNA-damaging signal to centrosome through its phosphorylation by ATM. CANCER SCIENCE. 2022. 113
Zhenzhou Fang, Xingming Li, Moe Suzuki, Yuki Yoshino, Huicheng Qi, Takahiro Mori, Natsuko Chiba. Aurora A-dependent ubiquitination of OLA1 regulates centrosome number via controlling the recruitment of PCM proteins. CANCER SCIENCE. 2022. 113. 499-499

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Patents (2)：

Books (1)：

Lectures and oral presentations (73)：

治療感受性予測のための腫瘍組織の相同組み換え活性測定法開発の基礎研究
(日本外科学会定期学術集会(Web) 2024)
乳癌発症リスク評価/治療効果予測を目指した臨床検体の相同組み換え修復活性評価法開発の基礎的検討
(日本乳癌学会総会プログラム抄録集 2023)
BARD1 suppresses the OLA1 polyubiquitination by Aurora A to regulate centrosome maturation
(日本癌学会学術総会抄録集(Web) 2023)
BRCA1-interacting protein OLA1 promotes DNA damage-induced centrosome amplification through the activation of PLK1
(日本癌学会学術総会抄録集(Web) 2023)
BRCA1-associated protein RACK1 regulates centrosome duplication in breast cancer cells
(日本癌学会学術総会抄録集(Web) 2023)

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Education (2)：

Professional career (1)：

Work history (3)：

2015/09 - 現在 Tohoku University Department of Cancer Biology, Institute of Aging, Development, and Cancer Assistant Proffessor
2015/04 - 2015/08 Tohoku University Department of Cancer Biology, Institute of Aging, Development, and Cancer Research associate
2009/04 - 2011/03 Tohoku University Tohoku University Hospital resident

Awards (8)：

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Association Membership(s) (4)：

日本臨床腫瘍学会 , 日本がん治療学会 , 日本癌学会 , 日本内科学会

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