Rchr
J-GLOBAL ID：201501012725344427   Update date: Jul. 24, 2023

Ito Keisuke

イトウ ケイスケ | Ito Keisuke
Affiliation and department：
Kobe University

About Kobe University


Job title： Assistant Professor
Research field  (1)： Developmental biology
Research theme for competitive and other funds  (5)：
  • 2022 - 2025 前肢に存在する「神経様細胞」の異常産生と、神経芽腫発症の共通分子基盤を探る
  • 2019 - 2022 Analysis of multipotency and its underlying molecular mechanisms of sympathetic nerve-associating Schwann cell precursors
  • 2015 - 2017 RET生体可視化ツールを用いた、発生と病理における受容体輸送研究
  • 2017 - 神経芽腫に対する新規治療剤の探索
  • 2006 - 2007 嗅索道標細胞(lot細胞)の移動機構の解析
Papers (9)：
  • Bayu Pratama Putra, Keisuke Ito, Carla Cirillo, Mukhamad Sunardi, Haruhiko Koseki, Toshihiro Uesaka, Hideki Enomoto. Pcgf1 gene disruption reveals primary involvement of epigenetic mechanism in neuronal subtype specification in the enteric nervous system. Development, growth & differentiation. 2023
  • Mukhamad Sunardi, Keisuke Ito, Yuya Sato, Toshihiro Uesaka, Mitsuhiro Iwasaki, Hideki Enomoto. A single RET mutation in Hirschsprung disease induces intestinal aganglionosis via a dominant-negative mechanism. Cellular and Molecular Gastroenterology and Hepatology. 2022. 15. 6. 1505-1524
  • Mukhamad Sunardi, Keisuke Ito, Hideki Enomoto. Live visualization of a functional RET-EGFP chimeric receptor in homozygous knock-in mice. Development, Growth & Differentiation. 2021. 63. 6. 285-294
  • Mitsumasa Okamoto, Toshihiro Uesaka, Keisuke Ito, Hideki Enomoto. Increased RET Activity Coupled with a Reduction in the RET Gene Dosage Causes Intestinal Aganglionosis in Mice. eneuro. 2021. 8. 3. ENEURO.0534-20.2021
  • Keisuke Ito, Hideki Enomoto. Retrograde transport of neurotrophic factor signaling: implications in neuronal development and pathogenesis. Journal of Biochemistry. 2016. 160. 2. 77-85
ｍore...
MISC (2)：
Lectures and oral presentations  (10)：
  • RET 活性化型変異 C618F は遺伝子量減少によりヒルシュスプルング病を誘導する
    (CSMIリトリート「若手道場」 2019)
  • Elevated levels of RET signaling coupled with decreased RET dose causes Hirschsprung's disease in mice
    (第2回神戸理研・神戸大学合同シンポジウム 2019)
  • RET 活性化型変異 C618F は遺伝子量減少によりヒルシュスプルング病を誘導する
    (第94回日本解剖学会近畿支部学術集会 2018)
  • CRISPR/Cas9システムによる遺伝子ノックアウト研究の進展と今後の課題
    (Neuroscience network in Kobe 定例研究会 2018)
  • Polarized intracellular trafficking of RET tyrosine kinase in living neurons
    (The 38th Annual Meeting of the Japan Neuroscience Society 2015)
ｍore...
Education (1)：
  • - 2007 総合研究大学院大学 大学院生命科学研究科博士課程後期課程修了
Professional career (2)：
  • 修士(理学) (名古屋大学)
  • 博士(理学) (総合研究大学院大学)
Awards (1)：
  • 2014/01 - 理化学研究所 理化学研究所 基礎科学・国際特別研究員 研究成果発表会ポスター賞 Analysis of Physiological Meanings of Intracellular Trafficking of the Neurotrophic Receptor, RET - Focusing on Development of the Enteric Nervous System
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