Noda Nobuo

ノダノブオ | Noda Nobuo

Affiliation and department：
Job title： Professor
Homepage URL (1)： https://kaken.nii.ac.jp/d/r/40396297.ja.html

Research field (4)： Functional biochemistry , Structural biochemistry , Cell biology , Pharmaceuticals - health and biochemistry

Research keywords (11)： Liquid-liquid phase separation , Autophagy , Membraneless organelle , Fluorescence Imaging , in vitro reconstitution , 天然変性タンパク質 , Cryo-EM , High-speed AFM , Solution NMR , Structural Biology , X線結晶構造解析

Research theme for competitive and other funds (15)：

2023 - 2030 Interdisciplinary research on autophagy: From working principles to pathophysiology
2023 - 2026 オートファジーを標的とする膵がんの新規治療法の開発
2022 - 2025 液-液相分離による「ねむり」制御の分子基盤の解明
2021 - 2024 Studies on the regulatory mechanism of aggresome formatiion and clearance
2019 - 2024 オートファジーシステムの構造学的解明

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Papers (127)：

Jahangir Md Alam, Tatsuro Maruyama, Daisuke Noshiro, Chika Kakuta, Tetsuya Kotani, Hitoshi Nakatogawa, Nobuo N Noda. Complete set of the Atg8-E1-E2-E3 conjugation machinery forms an interaction web that mediates membrane shaping. Nature structural & molecular biology. 2023
Daisuke Noshiro, Nobuo N Noda. Immobilization of lipid nanorods onto two-dimensional crystals of protein tamavidin 2 for high-speed atomic force microscopy. STAR protocols. 2023. 4. 4. 102633-102633
Tatsuro Maruyama, Yutaro Hama, Nobuo N Noda. Mechanisms of mitochondrial reorganization. The Journal of Biochemistry. 2023
Tomoyuki Fukuda, Kentaro Furukawa, Tatsuro Maruyama, Nobuo N Noda, Tomotake Kanki. Mitofissin: a novel mitochondrial fission protein that facilitates mitophagy. Autophagy. 2023. 19. 11. 3019-3021
Ryosuke Ishimura, Sota Ito, Gaoxin Mao, Satoko Komatsu-Hirota, Toshifumi Inada, Nobuo N. Noda, Masaaki Komatsu. Mechanistic insights into the roles of the UFM1 E3 ligase complex in ufmylation and ribosome-associated protein quality control. Science Advances. 2023. 9. 33

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MISC (64)：

池田良, 一村義信, 森下英晃, 能代大輔, 船越智子, 小松聡子, 蔭山俊, 野田展生, 小松雅明. ULK1キナーゼによるp62の液-液相分離制御. 日本Cell Death学会学術集会プログラム抄録集. 2022. 30th
石村亮輔, 能代大輔, 植村武文, 和栗聡, 野田展生, 小松雅明. UFM1システム:Alphafold2構造予測からわかったUFM1システムの作動原理. 日本Cell Death学会学術集会プログラム抄録集. 2022. 30th
藤岡優子, 野田展生. オートファジーにおける液-液相分離の機能. 日本蛋白質科学会年会プログラム・要旨集. 2022. 22nd (Web)
能代大輔, 野田展生. 液-液相分離と選択的オートファジー. 実験医学. 2021. 39. 2046-2051
野田展生. 蛋白質の液-液相分離. 細胞. 2021. 53. 529-532

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Lectures and oral presentations (9)：

オートファゴソーム新生の分子機構
(令和4 年度「感染・免疫・がん・炎症」全国共同研究拠点シンポジウム 2023)
オートファゴソーム膜の伸展・成形機構
(タンパク質研究シンポジウム~タンパク質研究はいま新たなステージに入ろうとしている!~ 2022)
Molecular mechanisms underlying autophagosome biogenesis
(The 17th International Symposium of the Institute Network for Biomedical Sciences 2022)
Mechanisms of autophagy initiation by liquid-liquid phase separation
(3rd Frankfurt Conference on Quality Control in Life Processes 2022)
液-液相分離によるオートファジー制御機構の解明
(第1回生理学研究所-遺伝子病制御研究所連携シンポジウム 2022)

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Education (1)：

1996 - 2001 The University of Tokyo Graduate School of Pharmaceutical Sciences

Professional career (1)：

博士(薬学) (東京大学)

Work history (7)：

2022/01 - 現在 Hokkaido University Institute for Genetic Medicine Professor
2017/04 - 2021/12 Microbial Chemistry Research Foundation Laboratory of Structural Biology, Institute of Microbial Chemistry Laboratory Head
2011/04 - 2017/03 Microbial Chemistry Research Foundation Institute of Microbial Chemistry Chief Researcher
2008/04 - 2011/03 Hokkaido University Graduate School of Pharmaceutical Sciences Lecturer with tenure
2007/04 - 2008/03 Hokkaido University Graduate School of Pharmaceutical Sciences Research associate

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Association Membership(s) (3)：

THE PHARMACEUTICAL SOCIETY OF JAPAN , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , THE JAPANESE BIOCHEMICAL SOCIETY

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