Rchr
J-GLOBAL ID:201501014062923510
Update date: Nov. 17, 2024
Noda Nobuo
ノダ ノブオ | Noda Nobuo
Affiliation and department:
Job title:
Professor
Homepage URL (1):
https://kaken.nii.ac.jp/d/r/40396297.ja.html
Research field (4):
Functional biochemistry
, Structural biochemistry
, Cell biology
, Pharmaceuticals - health and biochemistry
Research keywords (12):
Liquid-liquid phase separation
, Autophagy
, Membraneless organelle
, Fluorescence Imaging
, in vitro reconstitution
, 天然変性タンパク質
, cell biology
, Cryo-EM
, High-speed AFM
, Solution NMR
, Structural Biology
, X線結晶構造解析
Research theme for competitive and other funds (16):
- 2023 - 2030 Interdisciplinary research on autophagy: From working principles to pathophysiology
- 2024 - 2029 A study on stress responses by co-creation of liquid-liquid phase separation and autophagy
- 2023 - 2026 オートファジーを標的とする膵がんの新規治療法の開発
- 2022 - 2025 液-液相分離による「ねむり」制御の分子基盤の解明
- 2021 - 2024 Studies on the regulatory mechanism of aggresome formatiion and clearance
- 2019 - 2024 オートファジーシステムの構造学的解明
- 2018 - 2021 Elucidation of the function of the pre-autophagosomal structure through in vitro reconstitution
- 2018 - 2021 Chemical Biology for Parkinson's disease
- 2015 - 2018 International Activities Support for Autophagy Research
- 2013 - 2018 Structural basis of Atg proteins responsible for autophagy
- 2013 - 2018 Multidisciplinary research on autophagy: from molecular mechanisms to disease states
- 2012 - 2014 天然変性タンパク質Atg13によるオートファジー始動の制御機構
- 2012 - 2014 Prediction and screening of selective autophagy cargo in Saccharomyces cerevisiae
- 2011 - 2014 Structural basis of the autophagy-specific E1 enzyme Atg7
- 2006 - 2010 Structural analysis of the intracellular proteolytic system
- 2005 - 2009 Structural Biology of Innate Immunity
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Papers (130):
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Yuko Fujioka, Takuma Tsuji, Tetsuya Kotani, Hiroyuki Kumeta, Chika Kakuta, Toyoshi Fujimoto, Hitoshi Nakatogawa, Nobuo N Noda. Phase separation promotes Atg8 lipidation for autophagy progression. 2024
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Yutaro Hama, Yuko Fujioka, Hayashi Yamamoto, Noboru Mizushima, Nobuo N. Noda. The triad interaction of ULK1, ATG13, and FIP200 is required for ULK complex formation and autophagy. 2024
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Masaaki Komatsu, Toshifumi Inada, Nobuo N Noda. The UFM1 system: Working principles, cellular functions, and pathophysiology. Molecular cell. 2024. 84. 1. 156-169
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Jahangir Md Alam, Tatsuro Maruyama, Daisuke Noshiro, Chika Kakuta, Tetsuya Kotani, Hitoshi Nakatogawa, Nobuo N Noda. Complete set of the Atg8-E1-E2-E3 conjugation machinery forms an interaction web that mediates membrane shaping. Nature structural & molecular biology. 2024. 31. 170-178
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Daisuke Noshiro, Nobuo N Noda. Immobilization of lipid nanorods onto two-dimensional crystals of protein tamavidin 2 for high-speed atomic force microscopy. STAR protocols. 2023. 4. 4. 102633-102633
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MISC (68):
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森下 英晃, 来栖 玲央, 藤本 侑生, 能代 大輔, 高田 周平, 山野 晃史, 田中 秀明, 荒井 律子, 蔭山 俊, 船越 智子, et al. オートファジー研究から拡大する細胞質ゾーニングの世界 液-液相分離で形成される"p62 body"の新規構成成分の同定とその選択的オートファジーによる分解意義の解明. 日本生化学会大会プログラム・講演要旨集. 2023. 96回. [3S01m-03]
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一村義信, 池田良, 池田良, 能代大輔, 森下英晃, 森下英晃, 高田周平, 蔭山俊, 藤岡優子, 船越智子, et al. 相分離したp62bodyのULK1によるリン酸化は,酸化還元非依存的なストレス応答を活性化する. 日本生化学会大会(Web). 2023. 96th
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久保田裕二, 藤岡優子, 高木祐輔, 松原大祐, 飯島正富, 百瀬功, 中井謙太, 野田展生, 武川睦寛. Elucidation of molecular mechanisms of ERK hyper-activation and drug-resistance in cancers with MEK1 mutations. 日本癌学会学術総会抄録集(Web). 2022. 81st
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池田良, 一村義信, 森下英晃, 能代大輔, 船越智子, 小松聡子, 蔭山俊, 野田展生, 小松雅明. ULK1キナーゼによるp62の液-液相分離制御. 日本Cell Death学会学術集会プログラム抄録集. 2022. 30th
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石村亮輔, 能代大輔, 植村武文, 和栗聡, 野田展生, 小松雅明. UFM1システム:Alphafold2構造予測からわかったUFM1システムの作動原理. 日本Cell Death学会学術集会プログラム抄録集. 2022. 30th
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Lectures and oral presentations (9):
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オートファゴソーム新生の分子機構
(令和4 年度「感染・免疫・がん・炎症」全国共同研究拠点シンポジウム 2023)
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オートファゴソーム膜の伸展・成形機構
(タンパク質研究シンポジウム~タンパク質研究はいま新たなステージに入ろうとしている!~ 2022)
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Molecular mechanisms underlying autophagosome biogenesis
(The 17th International Symposium of the Institute Network for Biomedical Sciences 2022)
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Mechanisms of autophagy initiation by liquid-liquid phase separation
(3rd Frankfurt Conference on Quality Control in Life Processes 2022)
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液-液相分離によるオートファジー制御機構の解明
(第1回生理学研究所-遺伝子病制御研究所連携シンポジウム 2022)
more...
Education (1):
- 1996 - 2001 The University of Tokyo Graduate School of Pharmaceutical Sciences
Professional career (1):
Work history (7):
- 2022/01 - 現在 Hokkaido University Institute for Genetic Medicine Professor
- 2017/04 - 2021/12 Microbial Chemistry Research Foundation Laboratory of Structural Biology, Institute of Microbial Chemistry Laboratory Head
- 2011/04 - 2017/03 Microbial Chemistry Research Foundation Institute of Microbial Chemistry Chief Researcher
- 2008/04 - 2011/03 Hokkaido University Graduate School of Pharmaceutical Sciences Lecturer with tenure
- 2007/04 - 2008/03 Hokkaido University Graduate School of Pharmaceutical Sciences Research associate
- 2005/05 - 2007/03 Hokkaido University Graduate School of Pharmaceutical Sciences Research associate
- 2001/04 - 2005/04 Hokkaido University Graduate School of Pharmaceutical Sciences posdoc
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Association Membership(s) (4):
THE PHARMACEUTICAL SOCIETY OF JAPAN
, THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
, THE JAPANESE BIOCHEMICAL SOCIETY
, 日本癌学会
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