
	Chemical structure search How to Search	Import MOLfile format is only available (V3000 format is not available) Exact match Substructure search Superstructure search Substructure or superstructure search Similarity search

Details
Related links
Search

Co-authoring Researcher

Co-inventing Researcher

Researcher similar to the Researcher

Article similar to the Researcher

Patent similar to the Researcher

Research Project similar to the Researcher

Article(J-GLOBAL estimation)

Patent(J-GLOBAL estimation)

Rchr

J-GLOBAL ID：201501016996354130 Update date: Dec. 18, 2024

Takeya Motohiro

タケヤモトヒロ | Takeya Motohiro

Clips

Affiliation and department：
Homepage URL (1)： https://kaken.nii.ac.jp/d/r/90155052.ja.html

Research field (4)： Respiratory medicine , Experimental pathology , Human pathology , Metabolism and endocrinology

Research keywords (30)：マクロファージ , 免疫組織化学 , モノクローナル抗体 , スカベンジャー受容体 , SR-AI, II(CD204) , ACAT-1 , 肉芽腫 , CD204 , スカベンジャー受容体ファミリー , オルタナティブ活性化 , ノックアウトマウス , LOX-1 , CD36 , 天然化合物 , 単球 , LOX-1(Lectin-like oxidized LDL receptor-1) , CD204欠損マウス , MCP-1 , 免疫組織科学 , TRPM-3陽性マクロファージ , 遺伝子欠損マウス , 樹状細胞 , corosolic acid , MARCO受容体 , 泡沫細胞化 , マクロファージ活性化 , SR-AI,II , α1-antitrypsin , 組織マクロファージ , 粥状動脈硬化

Research theme for competitive and other funds (29)：

2017 - 2020 Strategic analysis for the development of new anticancer treatments targeting tumor-associated macrophages
2016 - 2019 Search of the new biomarkers reflecting lymph node macrophage function and its application to molecular pathology
2013 - 2016 Does the balance in lymphoma of immunity become the prognostic factor of cancer?
2013 - 2015 Analysis of activation pathways and functional heterogeneity of macrophages - beyond M1/M2 paradigm
2011 - 2013 Development of new therapeutic strategies for regulating macrophage activation by natural compounds

2011 - 2013 Therapeutic strategy for Niemann-Pick disease type C focusing on induction of ACAT1-positive late endosomes

2008 - 2010 ROLE OF SCAVENGER RECEPTORS IN MACROPHAGE ACTIVATION AND THEIR APPLICATION FOR DIAGNOSIS AND THERAPY

2008 - 2010 Functional analysis of the ACAT-1-positive late endosomes in cholesterol-rich macrophages

2007 - 2010 Academic project of oncogenic factors in malignant tumors and the related diseases in northeast China

2005 - 2007 Identification and characterization of novel vesicular organelle appearing hyperlipidemic human macrophages

2005 - 2007 Oxidative stress regulation through NO-induced nucleic acid nitration in pulmonary diseases

2004 - 2007 Application of CD204 (scavenger receptor) to histopathological diagnosis and production of new anti-macrophage antibodies

2004 - 2005 Elucidation of the mechanisms for intracellular accumulation of cholesterol ester and its application to therapies.

2002 - 2003 新しいマクロファージマーカーとしてのCD204(スカベンジャー受容体)抗体

2001 - 2003 IN VIVO EXPRESSION AND PATHOLOGICAL ROLES OF SCAVENGER RECEPTOR FAMILY MOLECULES

2001 - 2002 Roles of CD36 and SR-BI as novel AGE-receptors

2000 - 2002 Role of scavenger receptors in atherogenesis and development of new therapeutic methods

1998 - 2000 Macrophage scavenger receptor as a new macrophage marker

1999 - 1999 卵黄嚢における初期脈管形成に関する細胞学的ならびに分子病理学的研究

1998 - 1999 Development of quantitative analysis method of the atherosclerotic lesions in gene targeted mice

1997 - 1998 生体防御におけるマクロファージスカベンジャー受容体の役割

1997 - 1998 生体内におけるBリンパ球由来のマクロファージの発生機構の解明

1996 - 1998 Pathological Significance of Macrophage Scavenger Receptors

1996 - 1997 Role of Monocyte Chemoattractant Protein-1 in Various Pathological Conditions

1996 - 1996 マクロファージの腫瘍内浸潤機序の解明と単球遊走因子(MCP-1)の治療への応用

1993 - 1993 マクロファージの発生、分化、成熟に関する細胞病理学的・分子病理学的研究

1992 - 1992 炎症性サイトカインMCP-1の生体内における発現とその役割

1992 - 1992 動脈硬化病巣のスカベンジャーレセプター発現機構に関する分子病理学的研究

1989 - 1989 Kupffer細胞の増殖能及び細胞回転に関する研究

Show all

Papers (268)：

菰原義弘, 竹屋元裕. 【マクロファージの功罪-疾患病態誘導と制御におけるマクロファージの役割】がん・腫瘍がん・悪性腫瘍におけるマクロファージ. 医学のあゆみ. 2020. 273. 10. 986-992
Yasuhiro Sakai, Andri Rezano, Seiji Okada, Takahiro Ohtsuki, Yoshiaki Kawashima, Tetsuya Tsukamoto, Motoshi Suzuki, Michinori Kohara, Motohiro Takeya, Nobuo Sakaguchi, et al. A Novel Cytological Model of B-Cell/Macrophage Biphenotypic Cell Hodgkin Lymphoma in Ganp-Transgenic Mice. Cancers. 2020. 12. 1
Umemoto S, Haruta M, Sakisaka M, Ikeda T, Tsukamoto H, Komohara Y, Takeya M, Nishimura Y, Senju S. Cancer therapy with major histocompatibility complex-deficient and interferon β-producing myeloid cells derived from allogeneic embryonic stem cells. Cancer science. 2019. 110. 10. 3027-3037
Yamashita T, Ohnishi K, Ueda M, Masuda T, Inoue Y, Misumi Y, Ueda A, Obayashi K, Takeya M, Ando Y. Transthyretin amyloid-related cerebral angiitis after liver transplantation. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. 2019. 26. sup1. 11-12
Nana Motojima, Yuta Nakashima, Yukio Fujiwara, Yoshihiro Komohara, Motohiro Takeya, Hiromasa Miura, Kazunori Hino, Hidehiko Higaki, Hidehiro Hata, Yoshitaka Nakanishi. Relationship between wear behaviour of ultra-high-molecular-weight polyethylene and surface profile of Co-Cr-Mo alloy in artificial joint. Biosurface and Biotriology. 2019. 5. 1. 1-7

ｍore...

MISC (901)：

Shinya Endo, Nao Nishimura, Yawara Kawano, Niina Ueno, Shikiko Ueno, Hiro Tatetsu, Yoshihiro Komohara, Motohiro Takeya, Hiroyuki Hata, Hiroaki Mitsuya, et al. MUC1/KL-6 expression confers an aggressive phenotype upon myeloma cells. Biochemical and Biophysical Research Communications. 2018. 507. 1-4. 246-252
Hiroto Takeya, Takuya Shiota, Taisuke Yagi, Koji Ohnishi, Yoshifumi Baba, Yuko Miyasato, Yuki Kiyozumi, Naoya Yoshida, Motohiro Takeya, Hideo Baba, et al. High CD169 expression in lymph node macrophages predicts a favorable clinical course in patients with esophageal cancer. Pathology international. 2018. 68. 12. 685-693
秀拓一郎, 菰原義弘, 宮里祐子, 中村英夫, 牧野敬史, 竹屋元裕, 倉津純一, 武笠晃丈, 矢野茂敏. 腫瘍境界部のグリオーマ細胞は特殊な微小環境を利用し治療抵抗性を獲得する(Glioma cells at the tumor border acquire chemo-radioresisitant ability from the special microenvironments). 日本癌学会総会記事. 2018. 77回. 990-990
竹屋元裕, 菰原義弘, 藤原章雄. 【M2マクロファージと疾患】腫瘍随伴マクロファージ(TAM)とM2活性化. 臨床免疫・アレルギー科. 2018. 70. 1. 45-52
梅本覚司, 春田美和, 匂坂正孝, 粟井博丈, 池田徳典, 竹屋元裕, 菰原義弘, 西村泰治, 千住覚. MHC欠損ES細胞由来IFN産生ミエロイド細胞による大腸癌転移モデルのアロ個体への治療効果と宿主免疫系に及ぼす影響. 日本がん免疫学会総会プログラム・抄録集. 2018. 22回. 147-147

ｍore...

Patents (1)：

心筋障害抑制剤

Books (1)：

生命を支えるマクロファージ
文光堂 2001 ISBN:4830604409

Education (2)：

1977 - 1981 Kumamoto University Kumamoto University
1971 - 1977 Kumamoto University School of Medicine

Professional career (1)：

医学博士 (熊本大学)

Work history (12)：

2019/04 - 現在 Kumamoto Health Science University President
2015/04 - 2019/03 Kumamoto University
2003/04 - 2018/03 熊本大学大学院(細胞病理学分野) 教授
2011/04 - 2015/03 熊本大学生命科学研究部長・大学院医学教育部長・医学部長
2008/04 - 2011/03 熊本大学医学部副医学部長・医学科長

Show all

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page


	Free word	※Add the following synonyms, you can increase the number of hits.




		～