Takahashi Tsutomu

タカハシツトム | Takahashi Tsutomu

Affiliation and department：
Job title：講師
Other affiliations (1)：

法政大学理工学研究科非常勤講師

Homepage URL (1)： https://kaken.nii.ac.jp/d/r/00400474.ja.html

Research field (3)： Environmental effects of chemicals , Environmental effects of radiation , Pharmaceuticals - health and biochemistry

Research keywords (6)：亜ヒ酸 , 分子毒性学 , 環境汚染物質 , 血管毒性 , 制がん剤 , メチル水銀

Research theme for competitive and other funds (13)：

2023 - 2026 血管周囲脂肪組織に着目したヒ素の血管毒性発現機構の解明
2022 - 2025 メチル水銀による末梢感覚神経障害とその回復の機構解析
2017 - 2019 亜ヒ酸毒性発現機構におけるペントースリン酸経路の役割
2014 - 2016 メチル水銀が示す脳選択的毒性に対するセクレトグロビンの役割
2013 - 2014 オートファジー調節因子Ragulator複合体によるメチル水銀毒性軽減機構

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Papers (71)：

Eiko Yoshida, Kazuhiro Aoki, Yu Sasaki, Hinako Izuhara, Tsutomu Takahashi, Yasuyuki Fujiwara, Tomoya Fujie, Ke Du, Komyo Eto, Yo Shinoda, et al. Comparative study of susceptibility to methylmercury cytotoxicity in cell types composing rat peripheral nerves: a higher susceptibility of dorsal root ganglion neurons. The Journal of Toxicological Sciences. 2024. 49. 5. 241-248
Yo Shinoda, Yuta Yamada, Eiko Yoshida, Tsutomu Takahashi, Yayoi Tsuneoka, Komyo Eto, Toshiyuki Kaji, Yasuyuki Fujiwara. Hypoalgesia and recovery in methylmercury-exposed rats. The Journal of toxicological sciences. 2021. 46. 6. 303-309
Nakano T, Takahashi T, Yamamoto C, Kaji T, Fujiwara Y. Arsenite induces tissue factor synthesis through Nrf2 activation in cultured human aortic smooth muscle cells. The Journal of Toxicological Sciences. 2021. 46. 4. 187-192
Yo Shinoda, Daitetsu Kato, Ryosuke Ando, Hikaru Endo, Tsutomu Takahashi, Yayoi Tsuneoka, Yasuyuki Fujiwara. Systematic Review and Meta-Analysis of In Vitro Anti-Human Cancer Experiments Investigating the Use of 5-Aminolevulinic Acid (5-ALA) for Photodynamic Therapy. Pharmaceuticals. 2021. 14. 3. 229-229
Toyama T, Wang Y, Kim MS, Takahashi T, Naganuma A, Hwang GW. Increased expression of TCF3, transcription factor 3, is a defense response against methylmercury toxicity in mouse neuronal C17.2 cells. Toxicological Research. 2021

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MISC (7)：

Takahashi Tsutomu. A Screen for Genes Involved in Adriamycin Resistance in Saccharomyces cerevisiae. YAKUGAKU ZASSHI. 2013. 133. 3. 393-396
高橋勉. ウイルス感染とがん ~子宮頸がんの予防・早期発見のためのHPVワクチン接種と検診の現状~. 日本薬学会環境・衛生部会ホームページ「環境・衛生薬学トピックス」. 2011
TAKAHASHI Tsutomu. Studies on Molecular Mechanism of Toxicity of Anticancer Drugs. YAKUGAKU ZASSHI. 2011. 131. 3. 355-358
T. Takahashi, A. Naganuma. Nascent polypeptide-associated complex in ribosomes plays a key role in protection against adriamycin toxicity in budding yeast. TOXICOLOGY LETTERS. 2010. 196. S161-S161
Tsutomu Takahashi, Akira Naganuma. Involvement of a regulation system of endocytosis via phosphorylation in adriamycin resistance. YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN. 2007. 127. 167-168

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Books (4)：

衛生薬学 -健康の維持と増進をめざして-(早川磨紀男,藤原泰之,山折大編集)
京都廣川書店 2023 ISBN:9784910844091
毒性の科学 -分子・細胞から人間集団まで-
東京大学出版会 2014
Encyclopedia of Cancer, 2nd Edition.
2008
環境・健康科学事典
丸善 2005

Lectures and oral presentations (19)：

Induction of a reactive sulfur-producing enzyme cystathionine gamma-lyase in cultured vascular endothelial cells exposed to arsenite
(The 8th International Symposium on Metallomics (ISM-8) 2022)
亜ヒ酸による転写因子の活性制御を介した毒性発現メカニズム
(第63回日本薬学会関東支部大会 2019)
Arsenite exerts cytotoxic effect through inhibition of synthesis of ribose-5-phosphate in human acute monocytic leukemia THP-1 cells
(IUTOX 15th International Congress of Toxicology (ICTXV) 2019)
亜ヒ酸毒性発現機構におけるペントースリン酸経路の防御的役割
(日本薬学会第139年会 2019)
Arsenite suppresses expression of genes related to synthesis of ribose-5-phosphate in pentose phosphate pathway in human acute monocytic leukemia THP-1 cells
(The 8th International Congress of ASIAN Society of Toxicology (ASIATOX 2018) 2018)

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Education (2)：

1999 - 2004 Tohoku University Graduate School of Pharmaceutical Sciences
1995 - 1999 東北薬科大学薬学部薬学科

Professional career (1)：

博士(薬学) (東北大学)

Work history (6)：

2016/10 - 現在 Hosei University
2015/04 - 現在 Tokyo University of Pharmacy and Life Sciences School of Pharmacy
2007/07 - 2015/03 Tohoku University Graduate School of Pharmaceutical Sciences
2005/07 - 2007/06 Tohoku University Graduate School of Pharmaceutical Sciences
2005/04 - 2005/06 Tohoku University Graduate School of Pharmaceutical Sciences

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Committee career (7)：

2019/04 - 現在日本薬学会学術誌編集委員
2018/07 - 現在日本毒性学会生体金属部会幹事
2016/04 - 現在日本薬学会環境・衛生部会若手研究者活性化小委員会委員
2014/08 - 現在日本毒性学会 Fund. Toxicol. Sci. 誌 Editorial Board(査読委員)
2014/07 - 現在日本毒性学会評議委員

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Awards (11)：

2021/07 - 2021年度ファイザー賞(高頻度被引用論文賞) 日本毒性学会
2020/06 - 日本毒性学会田邊賞(年間優秀論文賞)
2017/07 - 日本毒性学会 2017年度ファイザー賞(高頻度被引用論文賞)
2015/11 - 第21回ヒ素シンポジウム奨励賞
2015/06 - 日本毒性学会田邊賞(年間優秀論文賞)

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Association Membership(s) (5)：

THE JAPANESE CANCER ASSOCIATION , THE JAPANESE BIOCHEMICAL SOCIETY , THE JAPANESE SOCIETY OF TOXICOLOGY , THE PHARMACEUTICAL SOCIETY OF JAPAN , 日本脳神経外科光線力学学会

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