Research theme for competitive and other funds (16):
2024 - 2027 Elucidating the Pathophysiology of Rheumatoid Arthritis and Strategies for Joint Regeneration through the Mechanisms of Senescent Cell Fate Determination
2023 - 2026 Elucidating the Divergence between Healthy Aging and Age-Related Diseases through Senescent-Origin Cells
2024 - 2026 Revealing the pathomechanisms of rheumatoid arthritis through exploring the intercellular networks woven by senescent cells
2023 - 2026 Understanding Stress-Resilient Cell-Cell Communications through Cellular Senescence
2018 - 2021 Regulation of muscle stem cell and mesenchymal stem cell by exercise induced metabolic and mechanical stress
2018 - 2021 Cellular senescence system of carpal tunnel syndrome and development of novel therapeutic methods
2016 - 2019 The role of muscle mesenchymal progenitors in exercise; double-edged sword of mesenchymal progenitors in muscular disease.
2016 - 2018 Do degenerated synovium with rheumatoid arthritis become scaffolds for abnormal synovial mesenchymal stem cells?
2013 - 2017 The Effects of Estradiol on Mesenchymal Stem Cells in Subsynovial Connective Tissue of Carpal Tunnel Syndrome
細胞老化から解明するうつ病の脳内慢性炎症メカニズムと新規治療法の開発
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Papers (39):
Yuki Saito, Sena Yamamoto, Takako S. Chikenji. Role of cellular senescence in inflammation and regeneration. Inflammation and Regeneration. 2024. 44. 1
Arisa Kita, Sena Yamamoto, Yuki Saito, Takako S. Chikenji. Cellular senescence and wound healing in aged and diabetic skin. Frontiers in Physiology. 2024. 15
Shogo Ijima, Yuki Saito, Sena Yamamoto, Kentaro Nagaoka, Taiki Iwamoto, Arisa Kita, Maki Miyajima, Tsukasa Sato, Akihiro Miyazaki, Takako S Chikenji. Senescence-associated secretory phenotypes in mesenchymal cells contribute to cytotoxic immune response in oral lichen planus. Immunity & ageing : I & A. 2023. 20. 1. 72-72
Yuki Saito, Maki Miyajima, Sena Yamamoto, Norihiro Miura, Tsukasa Sato, Arisa Kita, Shogo Ijima, Mineko Fujimiya, Takako S Chikenji. Intrathecal Injection of Mesenchymal Stromal Cell Cultured on 3D Fiber Ameliorates Multiple Organ Damage in Murine Lupus. Stem Cells Translational Medicine. 2022
Arisa Kita, Yuki Saito, Norihiro Miura, Maki Miyajima, Sena Yamamoto, Tsukasa Sato, Takatoshi Yotsuyanagi, Mineko Fujimiya, Takako S. Chikenji. Altered regulation of mesenchymal cell senescence in adipose tissue promotes pathological changes associated with diabetic wound healing. Communications Biology. 2022. 5. 1
Cellular senescence of synovial fibroblasts in rheumatoid arthritis model mice
(An ASCB|EMBO meeting Cell Bio 2023 2023)
Cellular Senescence in Epidermal Stem Cells as a Potential Driver of Lupus Erythematosus Skin Lesions
(An ASCB|EMBO meeting Cell Bio 2023 2023)
Exercise-induced senescence-like gene signature in fibro/adipogenic progenitors is impaired in diabetes muscle
(An ASCB|EMBO meeting Cell Bio 2023 2023)
Involvement of Cellular Senescence in the Pathogenesis of Lupus Nephritis in Mice
(An ASCB|EMBO meeting Cell Bio 2023 2023)
Identification of TGFB1-upregulated senescent fibroblasts in keloids
(5th FHS International Conference 2023)
2021/04 - 現在 Hokkaido University Faculty of Health Sciences Professor
2019/04 - 2021/03 Hokkaido University Associate professor
2018/07 - 2019/06 Mayo Clinic Research fellow
2014/10 - 2018/07 Sapporo Medical University School of Medicine Department of Anatomy Assistant professor
2013/04 - 2014/09 Sapporo Medical University School of Health Sciences
2010 - 2012 Mayo Clinic Research Fellow
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Awards (2):
2020/06 - 北海道大学大学院保健科学研究院 優秀論文賞
2020/02 - Orthopedics Research Society 2020 New Investigator Recognition Award (NIRA), Corresponding author
Association Membership(s) (7):
日本ハンドセラピィ学会
, JAPANESE ASSOCIATION OF OCCUPATIONAL THERAPISTS
, JAPANESE SOCIETY FOR SURGERY OF THE HAND
, THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE
, International Cell Senescence Association
, Orthopedic Research Society
, 日本炎症再生学会