Rchr
J-GLOBAL ID:201501053011063391   Update date: Nov. 01, 2019

Hiroshi Kimura

キムラ ヒロシ | Hiroshi Kimura
Affiliation and department:
Job title: Professor
Homepage URL  (2): http://kimura-lab.bio.titech.ac.jp/http://kimura-lab.bio.titech.ac.jp/
Research field  (5): Molecular biology ,  Cell biology ,  Genetics/Genome dynamics ,  Genetics/Chromosome dynamics ,  Biophysics
Research keywords  (10): chromatin ,  chromosome ,  cell nucleus ,  epigenetics ,  gene regulation ,  histone modification ,  live cell imaging ,  nucleosome ,  monoclonal antibody ,  FRAP
Research theme for competitive and other funds  (3):
  • 2007 - 2009 The structure and dynamics of chromatin harboring specific histone modifications
  • 2004 - 2008 Molecular mechanisms of chromatin formation and dynamics
  • 2003 - 2005 Regulation of gene expression and chromatin dynamics in living cells
Papers (176):
  • Ohka F, Shinjo K, Deguchi S, Matsui Y, Okuno Y, Katsushima K, Suzuki M, Kato A, Ogiso N, Yamamichi A, Aoki K, Suzuki H, Sato S, Arul Rayan N, Prabhakar S, Göke J, Shimamura T, Maruyama R, Takahashi S, Suzumura A, Kimura H, Wakabayashi T, Zong H, Natsume A, Kondo Y. Pathogenic Epigenetic Consequences of Genetic Alterations in IDH-Wild-Type Diffuse Astrocytic Gliomas. Cancer research. 2019. 79. 19. 4814-4827
  • Karoutas A, Szymanski W, Rausch T, Guhathakurta S, Rog-Zielinska EA, Peyronnet R, Seyfferth J, Chen HR, de Leeuw R, Herquel B, Kimura H, Mittler G, Kohl P, Medalia O, Korbel JO, Akhtar A. The NSL complex maintains nuclear architecture stability via lamin A/C acetylation. Nature cell biology. 2019. 21. 10. 1248-1260
  • Suda K, Muraoka Y, Ortega-Yáñez A, Yoshida H, Kizu F, Hochin T, Kimura H, Yamaguchi M. Reduction of Rpd3 suppresses defects in locomotive ability and neuronal morphology induced by the knockdown of Drosophila SLC25A46 via an epigenetic pathway. Experimental cell research. 2019. 111673
  • Sato Y, Hilbert L, Oda H, Wan Y, Heddleston JM, Chew TL, Zaburdaev V, Keller P, Lionnet T, Vastenhouw N, Kimura H. Histone H3K27 acetylation precedes active transcription during zebrafish zygotic genome activation as revealed by live-cell analysis. Development (Cambridge, England). 2019. 146. 19
  • Horikoshi N, Kujirai T, Sato K, Kimura H, Kurumizaka H. Structure-based design of an H2A.Z.1 mutant stabilizing a nucleosome in vitro and in vivo. Biochemical and biophysical research communications. 2019. 515. 4. 719-724
more...
MISC (21):
  • 木村宏, 佐藤優子. 未来を切り拓く先端的な生命科学への挑戦 遺伝子発現の理解と制御のための「ヌクレオーム」研究とエピゲノム編集. JATAFFジャーナル. 2019. 7. 5. 3-6
  • 木村宏. 光学顕微鏡 14.共焦点レーザー走査顕微鏡 iii.FRAP/FLIP-フォトブリーチによる生細胞内分子動態計測. 実験医学. 2018. 36. 20. 3398-3399
  • 木村宏. 染色体はどのような部品からできているのか?5.ヒストンの細胞内ダイナミクス. 実験医学. 2018. 36. 17. 2890-2896
  • 木村宏. ヒストン修飾と特異的モノクローナル抗体. Dojin News. 2018. 166. 1-5
  • 木村宏. 細胞核・クロマチン動態の生細胞イメージング. バイオイメージング. 2018. 27. 2. 64
more...
Lectures and oral presentations  (36):
  • 真核細胞DNA in vitro複製系の構築に向けて
    (日本分子生物学会年会プログラム・講演要旨集 1996)
  • 細胞周期で変動性を示すニワトリ高分子核タンパク質HMNAの解析
    (日本分子生物学会年会プログラム・講演要旨集 1996)
  • マウスMCM2蛋白質の分子解剖
    (日本分子生物学会年会プログラム・講演要旨集 1998)
  • 染色体の損傷と分配異常に伴うヒストン修飾のダイナミクス
    (日本放射線影響学会大会講演要旨集 2009)
  • ストレス誘導性遺伝子の再吸水過程における転写とヒストン修飾の変化
    (日本植物生理学会年会およびシンポジウム 講演要旨集 2009)
more...
Education (2):
  • 1984 - 1987 Hokkaido University Faculty of Science Department of Chemistry II
  • 1987 - 1991 Hokkaido University Graduate School of Science Department of Chemistry II
Professional career (1):
  • PhD (Hokkaido University)
Awards (1):
  • 2015/08 - The Society for Histochemisty Robert Feulgen Prize
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