Sou Yu-shin

Affiliation and department：
Homepage URL (1)： https://kaken.nii.ac.jp/d/r/60576221.ja.html

Research field (3)： Anatomy , Molecular biology , Pathobiochemistry

Research keywords (5)：ゴルジ体 , GPHR , オートファジー , p62 , Nbr1

Research theme for competitive and other funds (7)：

2019 - 2022 Cellular cholesterol homeostasis and luminal pH of the Golgi apparatus
2015 - 2018 Impairment of Golgi pH homeostasis cause neurodegeneration
2015 - 2016 ゴルジ体酸性環境不全に起因する病態発症機序の解明研究課題
2012 - 2014 pathophysiological analysis of autophagic substrate Nbr1.
2012 - 2013 オートファジー選択基質Nbr1の病態生理

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Papers (31)：

Yu-Shin Sou, Junji Yamaguchi, Hiroshi Kameda, Keisuke Masuda, Yusuke Maeda, Yasuo Uchiyama, Masato Koike. GPHR-mediated acidification of the Golgi lumen is essential for cholesterol biosynthesis in the brain. FEBS letters. 2022. 596. 22. 2873-2888
Mohammad Omar Faruk, Yoshinobu Ichimura, Shun Kageyama, Satoko Komatsu-Hirota, Afnan H El-Gowily, Yu-Shin Sou, Masato Koike, Nobuo N Noda, Masaaki Komatsu. Phase-separated protein droplets of amyotrophic lateral sclerosis-associated p62/SQSTM1 mutants show reduced inner fluidity. The Journal of biological chemistry. 2021. 297. 6. 101405-101405
Shun Kageyama, Sigurdur Runar Gudmundsson, Yu-Shin Sou, Yoshinobu Ichimura, Naoki Tamura, Saiko Kazuno, Takashi Ueno, Yoshiki Miura, Daisuke Noshiro, Manabu Abe, et al. p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response. Nature communications. 2021. 12. 1. 16-16
Pablo Sánchez-Martín, Yu-Shin Sou, Shun Kageyama, Masato Koike, Satoshi Waguri, Masaaki Komatsu. NBR1-mediated p62-liquid droplets enhance the Keap1-Nrf2 system. EMBO reports. 2020. 21. 3. e48902
Shun-Saku Takahashi, Yu-Shin Sou, Tetsuya Saito, Akiko Kuma, Takayuki Yabe, Yuki Sugiura, Hyeon-Cheol Lee, Makoto Suematsu, Takehiko Yokomizo, Masato Koike, et al. Loss of autophagy impairs physiological steatosis by accumulation of NCoR1. Life science alliance. 2020. 3. 1. doi: 10.26508/lsa.201900513

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MISC (26)：

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Work history (3)：

Association Membership(s) (2)：

日本神経科学学会 , THE JAPANESE ASSOCIATION OF ANATOMISTS

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