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J-GLOBAL ID：201501064102658446   Update date: Apr. 01, 2025

Sou Yu-shin

Sou Yu-shin
Affiliation and department：
Juntendo University School of Medicine

About Juntendo University School of Medicine


Homepage URL  (1)： https://kaken.nii.ac.jp/d/r/60576221.ja.html
Research field  (3)： Anatomy ,  Molecular biology ,  Pathobiochemistry
Research keywords  (5)： ゴルジ体 ,  GPHR ,  オートファジー ,  p62 ,  Nbr1
Research theme for competitive and other funds  (8)：
  • 2023 - 2026 オルガネラ酸性pHとPI4P局在の相関性の解明
  • 2019 - 2022 Cellular cholesterol homeostasis and luminal pH of the Golgi apparatus
  • 2015 - 2018 Impairment of Golgi pH homeostasis cause neurodegeneration
  • 2015 - 2016 ゴルジ体酸性環境不全に起因する病態発症機序の解明 研究課題
  • 2012 - 2014 pathophysiological analysis of autophagic substrate Nbr1.
Show all
Papers (33)：
  • Yu-Shin Sou, Junji Yamaguchi, Keisuke Masuda, Yasuo Uchiyama, Yusuke Maeda, Masato Koike. Golgi pH homeostasis stabilizes the lysosomal membrane through N-glycosylation of membrane proteins. Life science alliance. 2024. 7. 10
  • Yoshinobu Ichimura, Yuki Sugiura, Yoshinori Katsuragi, Yu-Shin Sou, Takefumi Uemura, Naoki Tamura, Satoko Komatsu-Hirota, Takashi Ueno, Masato Koike, Satoshi Waguri, et al. Loss of SPNS1, a lysosomal transporter, in the nervous system causes dysmyelination and white matter dysplasia. 2024
  • Yu-Shin Sou, Junji Yamaguchi, Hiroshi Kameda, Keisuke Masuda, Yusuke Maeda, Yasuo Uchiyama, Masato Koike. GPHR-mediated acidification of the Golgi lumen is essential for cholesterol biosynthesis in the brain. FEBS letters. 2022. 596. 22. 2873-2888
  • Mohammad Omar Faruk, Yoshinobu Ichimura, Shun Kageyama, Satoko Komatsu-Hirota, Afnan H El-Gowily, Yu-Shin Sou, Masato Koike, Nobuo N Noda, Masaaki Komatsu. Phase-separated protein droplets of amyotrophic lateral sclerosis-associated p62/SQSTM1 mutants show reduced inner fluidity. The Journal of biological chemistry. 2021. 297. 6. 101405-101405
  • Shun Kageyama, Sigurdur Runar Gudmundsson, Yu-Shin Sou, Yoshinobu Ichimura, Naoki Tamura, Saiko Kazuno, Takashi Ueno, Yoshiki Miura, Daisuke Noshiro, Manabu Abe, et al. p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response. Nature communications. 2021. 12. 1. 16-16
ｍore...
MISC (28)：
ｍore...
Work history (3)：
  • 2014/04 - 現在 Juntendo University Faculty of Medicine
  • 2011/04 - 2014/03 Tokyo Metropolitan Institute of Medical Science
  • 2009/04 - 2011/03 Japan Society for the Promotion of Science
Association Membership(s) (2)：
日本神経科学学会 ,  THE JAPANESE ASSOCIATION OF ANATOMISTS
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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