Rchr
J-GLOBAL ID:201501064102658446
Update date: Nov. 05, 2024
Sou Yu-shin
Sou Yu-shin
Affiliation and department:
Juntendo University School of Medicine
About Juntendo University School of Medicine
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Detailed information
Homepage URL (1):
https://kaken.nii.ac.jp/d/r/60576221.ja.html
Research field (3):
Anatomy
, Molecular biology
, Pathobiochemistry
Research keywords (5):
ゴルジ体
, GPHR
, オートファジー
, p62
, Nbr1
Research theme for competitive and other funds (7):
2019 - 2022 Cellular cholesterol homeostasis and luminal pH of the Golgi apparatus
2015 - 2018 Impairment of Golgi pH homeostasis cause neurodegeneration
2015 - 2016 ゴルジ体酸性環境不全に起因する病態発症機序の解明 研究課題
2012 - 2014 pathophysiological analysis of autophagic substrate Nbr1.
2012 - 2013 オートファジー選択基質Nbr1の病態生理
2010 - 2010 オートファジー選択的基質Nbr1の代謝異常と病態発症機序の解明
2007 - 2009 オートファジーによる異常タンパク質分解機構の解析
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Papers (32):
Yu-Shin Sou, Junji Yamaguchi, Keisuke Masuda, Yasuo Uchiyama, Yusuke Maeda, Masato Koike. Golgi pH homeostasis stabilizes the lysosomal membrane through N-glycosylation of membrane proteins. Life science alliance. 2024. 7. 10
Yu-Shin Sou, Junji Yamaguchi, Hiroshi Kameda, Keisuke Masuda, Yusuke Maeda, Yasuo Uchiyama, Masato Koike. GPHR-mediated acidification of the Golgi lumen is essential for cholesterol biosynthesis in the brain. FEBS letters. 2022. 596. 22. 2873-2888
Mohammad Omar Faruk, Yoshinobu Ichimura, Shun Kageyama, Satoko Komatsu-Hirota, Afnan H El-Gowily, Yu-Shin Sou, Masato Koike, Nobuo N Noda, Masaaki Komatsu. Phase-separated protein droplets of amyotrophic lateral sclerosis-associated p62/SQSTM1 mutants show reduced inner fluidity. The Journal of biological chemistry. 2021. 297. 6. 101405-101405
Shun Kageyama, Sigurdur Runar Gudmundsson, Yu-Shin Sou, Yoshinobu Ichimura, Naoki Tamura, Saiko Kazuno, Takashi Ueno, Yoshiki Miura, Daisuke Noshiro, Manabu Abe, et al. p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response. Nature communications. 2021. 12. 1. 16-16
Pablo Sánchez-Martín, Yu-Shin Sou, Shun Kageyama, Masato Koike, Satoshi Waguri, Masaaki Komatsu. NBR1-mediated p62-liquid droplets enhance the Keap1-Nrf2 system. EMBO reports. 2020. 21. 3. e48902
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MISC (26):
曽友深, 前田祐輔, 木下タロウ, 小池正人. ゴルジ体酸性環境が担う適切な糖鎖修飾の変化がリソソームに与える影響. 日本解剖学会総会・全国学術集会講演プログラム・抄録集. 2022. 127th (CD-ROM)
曽 友深, 角田 宗一郎, 前田 祐輔, 木下 タロウ, 崎村 建司, 内山 安男, 小池 正人. 小脳神経細胞におけるゴルジ体酸性環境の重要性. 生命科学系学会合同年次大会. 2017. 2017年度. [2P-1177]
曽友深, 角田宗一郎, 前田祐輔, 木下タロウ, 崎村建司, 内山安男, 小池正人. 小脳神経細胞におけるゴルジ体酸性環境の重要性. 日本生化学会大会(Web). 2017. 90th. ROMBUNNO.2P-1177 (WEB ONLY)-1177]
曽友深, 亀田宗一郎, 前田祐輔, 木下タロウ, 渡辺雅彦, 崎村建司, 内山安男, 小池正人. ゴルジ体酸性環境不全に起因する病態発症機序の解明. 日本解剖学会総会・全国学術集会講演プログラム・抄録集. 2017. 122nd. 212
蔭山 俊, 和栗 聡, 鐘ヶ江 裕美, 曽 友深, 一村 義信, 斎藤 泉, 福田 光則, 小松 雅明. Alfyによるメンブレントラフィック制御. 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2015. 88回・38回. [2P0069]-[2P0069]
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Work history (3):
2014/04 - 現在 Juntendo University Faculty of Medicine
2011/04 - 2014/03 Tokyo Metropolitan Institute of Medical Science
2009/04 - 2011/03 Japan Society for the Promotion of Science
Association Membership(s) (2):
日本神経科学学会
, THE JAPANESE ASSOCIATION OF ANATOMISTS
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