Rchr
J-GLOBAL ID:201501064102658446   Update date: Nov. 05, 2024

Sou Yu-shin

Sou Yu-shin
Affiliation and department:
Homepage URL  (1): https://kaken.nii.ac.jp/d/r/60576221.ja.html
Research field  (3): Anatomy ,  Molecular biology ,  Pathobiochemistry
Research keywords  (5): ゴルジ体 ,  GPHR ,  オートファジー ,  p62 ,  Nbr1
Research theme for competitive and other funds  (7):
  • 2019 - 2022 Cellular cholesterol homeostasis and luminal pH of the Golgi apparatus
  • 2015 - 2018 Impairment of Golgi pH homeostasis cause neurodegeneration
  • 2015 - 2016 ゴルジ体酸性環境不全に起因する病態発症機序の解明 研究課題
  • 2012 - 2014 pathophysiological analysis of autophagic substrate Nbr1.
  • 2012 - 2013 オートファジー選択基質Nbr1の病態生理
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Papers (32):
  • Yu-Shin Sou, Junji Yamaguchi, Keisuke Masuda, Yasuo Uchiyama, Yusuke Maeda, Masato Koike. Golgi pH homeostasis stabilizes the lysosomal membrane through N-glycosylation of membrane proteins. Life science alliance. 2024. 7. 10
  • Yu-Shin Sou, Junji Yamaguchi, Hiroshi Kameda, Keisuke Masuda, Yusuke Maeda, Yasuo Uchiyama, Masato Koike. GPHR-mediated acidification of the Golgi lumen is essential for cholesterol biosynthesis in the brain. FEBS letters. 2022. 596. 22. 2873-2888
  • Mohammad Omar Faruk, Yoshinobu Ichimura, Shun Kageyama, Satoko Komatsu-Hirota, Afnan H El-Gowily, Yu-Shin Sou, Masato Koike, Nobuo N Noda, Masaaki Komatsu. Phase-separated protein droplets of amyotrophic lateral sclerosis-associated p62/SQSTM1 mutants show reduced inner fluidity. The Journal of biological chemistry. 2021. 297. 6. 101405-101405
  • Shun Kageyama, Sigurdur Runar Gudmundsson, Yu-Shin Sou, Yoshinobu Ichimura, Naoki Tamura, Saiko Kazuno, Takashi Ueno, Yoshiki Miura, Daisuke Noshiro, Manabu Abe, et al. p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response. Nature communications. 2021. 12. 1. 16-16
  • Pablo Sánchez-Martín, Yu-Shin Sou, Shun Kageyama, Masato Koike, Satoshi Waguri, Masaaki Komatsu. NBR1-mediated p62-liquid droplets enhance the Keap1-Nrf2 system. EMBO reports. 2020. 21. 3. e48902
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MISC (26):
Work history (3):
  • 2014/04 - 現在 Juntendo University Faculty of Medicine
  • 2011/04 - 2014/03 Tokyo Metropolitan Institute of Medical Science
  • 2009/04 - 2011/03 Japan Society for the Promotion of Science
Association Membership(s) (2):
日本神経科学学会 ,  THE JAPANESE ASSOCIATION OF ANATOMISTS
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