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J-GLOBAL ID：201501077719678317   Update date: Apr. 12, 2025

OCHIAI HIROSHI

オチアイ ヒロシ | OCHIAI HIROSHI
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Affiliation and department：
Kyushu University Division of Gene Expression Dynamics, Medical Research Center Initiative for High Depth Omics, Medical Institute of Bioregulation

About Kyushu University Division of Gene Expression Dynamics, Medical Research Center Initiative for High Depth Omics, Medical Institute of Bioregulation


Job title： Professor
Homepage URL  (2)： https://www.bioreg.kyushu-u.ac.jp/labo/ged/ ,  https://www.bioreg.kyushu-u.ac.jp/labo/ged/en/
Research field  (4)： Genomics ,  Environmental effects of chemicals ,  Environmental effects of radiation ,  Systems genomics
Research keywords  (14)： SNP ,  遺伝子ターゲティング ,  一塩基置換 ,  遺伝病 ,  遺伝子挿入 ,  TALEN ,  zinc-finger nuclease ,  ゲノム編集 ,  Gene expression noise ,  Live imaging ,  CRISPR ,  ES cell ,  pluripotent stem cells ,  single cell analysis
Research theme for competitive and other funds  (23)：
  • 2024 - 2029 哺乳類初期発生における細胞可塑性を制御するエピコードの解読
  • 2023 - 2029 Understanding the mammalian cell fate regulation framework through multimodal spatiotemporal integrated omics analysis
  • 2022 - 2025 Elucidation of the linkage between higher-order genome structural dynamics and gene expression
  • 2023 - 2025 転写動態制御を担うゲノムモダリティ要因の理解
  • 2022 - 2024 Elucidation of the linkage between non-genomic information replication and transcriptional dynamics between sister chromatids
Show all
Papers (40)：
  • Soundhararajan Gopi, Giovanni B Brandani, Cheng Tan, Jaewoon Jung, Chenyang Gu, Azuki Mizutani, Hiroshi Ochiai, Yuji Sugita, Shoji Takada. In silico nanoscope to study the interplay of genome organization and transcription regulation. Nucleic Acids Research. 2025. 53. 6
  • Yosuke Yoneyama, Ran-Ran Zhang, Mari Maezawa, Hideki Masaki, Masaki Kimura, Yuqi Cai, Mike Adam, Sreeja Parameswaran, Naoaki Mizuno, Joydeep Bhadury, et al. Intercellular mRNA transfer alters the human pluripotent stem cell state. Proceedings of the National Academy of Sciences. 2025. 122. 4
  • Yuma Ito, Kosuke Tomimatsu, Masao Nagasaki, Hiroshi Ochiai, Yasuyuki Ohkawa. MEGA-FISH: multi-omics extensible GPU-accelerated FISH processing framework for huge-scale spatial omics. bioRxiv. 2024
  • Hiroaki Ohishi, Soya Shinkai, Hitoshi Owada, Takeru Fujii, Kazufumi Hosoda, Shuichi Onami, Takashi Yamamoto, Yasuyuki Ohkawa, Hiroshi Ochiai. Transcription-coupled changes in genomic region proximities during transcriptional bursting. Science Advances. 2024. 10. 49. adn0020
  • Hiroaki Ohishi, Hiroshi Ochiai. Image Analysis Protocol for DNA/RNA/Immunofluorescence (IF)-seqFISH Data. Methods in Molecular Biology. 2024. 419-432
ｍore...
MISC (28)：
  • 落合 博, 大川 恭行. 創薬研究を加速する空間オミクス技術. 実験医学増刊 あなたのラボから薬を生み出す アカデミア創薬の実践 All JAPAN体制の先端技術支援を利用した創薬の最前線. 2024. 42. 2
  • Hiroshi Ochiai, Hiroaki Ohishi, Yuko Sato, Hiroshi Kimura. Organization of transcription and 3D genome as revealed by live-cell imaging. Current Opinion in Structural Biology. 2023. 81. 102615-102615
  • Hiroshi Ochiai. Facilitating genome function understanding using genome editing dependent bioimaging techniques. Gene and Genome Editing. 2023. 5. 100022
  • 大石裕晃, 落合 博. 特定RNA分子/DNA領域のライブイメージング技術. 生体の科学. 2023. 74. 3. 260-265
  • Hiroshi Ochiai. Fluctuation and Biological Function. The Cell. 2023. 55. 3
ｍore...
Patents (3)：
  • 複数蛍光色素定量方法および装置
  • 細胞の作製方法および該作製方法で作製された細胞
  • DNA結合ドメインを含むポリペプチド
Books (7)：
  • 実験医学別冊 最強のステップUPシリーズ エピゲノムをもっと見るためのクロマチン解析実践プロトコール (大川恭行,宮成悠介/編)
    羊土社 2020 ISBN:9784758122481
  • 実験医学別冊 完全版 ゲノム編集実験スタンダード CRISPR-Cas9の設計・作製と各生物種でのプロトコールを徹底解説 (山本 卓,佐久間哲史/編)
    羊土社 2019
  • 医療応用をめざすゲノム編集 最新動向から技術・倫理的課題まで 真下 知士/金田 安史編
    KAGAKUDOJIN 2018
  • Genome Editing in Animals
    Springer New York 2017 ISBN:9781493971282
  • All Aboutゲノム編集 “革命的技術”はいかにして私たちの研究・医療・産業を変えるのか? 真下知士,山本 卓/編
    羊土社 2016 ISBN:9784758103596
ｍore...
Lectures and oral presentations  (68)：
  • 細胞間遺伝子発現多様性を駆動する転写バースト制御機構の解明
    (Cross-disciplinary Conference 2025 2025)
  • 空間マルチオミクス技術から明らかにする高次ゲノム構造変化と転写動態の関係性
    (第23回 日本心臓血管発生研究会 2024)
  • 3D genome architecture and its influence on gene regulation during transcriptional bursting
    (International Symposium: The 3D genome 2024)
  • Changes in higher-order genomic structures coupled with transcriptional states in mouse embryonic stem cells
    (The 33rd Hot Spring Harbor International Symposium 2024 2024)
  • 転写バーストにおけるヒストンアセチル化の動態変動
    (令和6年遺伝研究会 クロマチン・細胞核構造の動的変換とゲノム機能制御 2024)
ｍore...
Education (3)：
  • 2008 - 2011 Hiroshima University Graduate School, Division of Natural Science Department of Mathematical and Life Sciences
  • 2007 - 2008 Hiroshima University Graduate School, Division of Natural Science Department of Mathematical and Life Sciences
  • 2003 - 2007 Hiroshima University Faculty of Science Departmet of Biological Science
Professional career (1)：
  • PhD (Science) (Hiroshima University)
Work history (8)：
  • 2023/03 - 現在 Kyushu University Division of Gene Expression Dynamics, Medical Research Center Initiative for High Depth Omics, Medical Institute of Bioregulation Professor
  • 2021/04 - 2023/02 Hiroshima University Graduate School of Integrated Sciences for Life Associate Professor
  • 2019/04 - 2021/03 Hiroshima University Graduate School of Integrated Sciences for Life Lecturer
  • 2015/10/01 - 2019/03/31 Japan Science and Technology Agency Graduate School of Science, Department of Mathematical and Life Sciences, Hiroshima University PRESTO researcher
  • 2013/04/01 - 2015/09/30 Hiroshima University Graduate School of Science Lecturer (Special Appointment)
Show all
Committee career (9)：
  • 2024/08 - 2026/06 The Japanese Society for Genome Editing Member, Future Planning Committee
  • 2022/01 - 2024/12 Associate Editor of Journal of Biochemistry
  • 2021/08 - 2023/07 Ministry of Education, Culture, Sports, Science and Technology - Japan Senior Scientific Research Specialist, Grants-in-Aid for Scientific Research (KAKENHI)
  • 2022/10 - 2023/06 8th Annual Meeting of the Japanese Society for Genome Editing Conference Preparation Committee
  • 2022/03 - 2022/04 日本ゲノム編集学会 日本ゲノム編集学会 選挙管理委員長
Show all
Awards (6)：
  • 2023/06 - 日本エピジェネティクス研究会 日本エピジェネティクス研究会第16回年会 奨励賞 生細胞単一遺伝子イメージングによる転写動態のエピジェネティック制御機構の解明
  • 2021/10 - Hiroshima University Distinguished Researcher
  • 2021/05/11 - 広島大学 広島大学大学院統合生命科学研究科 統合生命科学研究科奨励賞
  • 2016/11 - Hiroshima University President Award
  • 2008/06 - Hiroshima University Excellent Student Scholarship
Show all
Association Membership(s) (4)：
THE BIOPHYSICAL SOCIETY OF JAPAN ,  The Japanese society for Genome Editing ,  The Japanese Society for Epigenetics ,  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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