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J-GLOBAL ID:201601000520760001   Update date: Feb. 17, 2025

Hamazaki Jun

ハマザキ ジュン | Hamazaki Jun
Affiliation and department:
Research field  (1): Molecular biology
Research keywords  (3): ユビキチン ,  タンパク質分解 ,  プロテアソーム
Research theme for competitive and other funds  (8):
  • 2022 - 2025 プロテアソーム不全に応答する新たなプロテアソーム機能維持機構の解明
  • 2019 - 2022 Elucidation of a novel homeostatic mechanism by enhanced O-GlcNAcylation under proteasome dysfunction
  • 2016 - 2019 Analysis of the mechanism of the degradation of aggregation prone proteiins by a novel ubiquitin binding protein CG5445
  • 2014 - 2019 Elucidation of redox regulatory mechanisms by transcription factor network
  • 2012 - 2015 Analysis of the mechanism of the regulation of proteasome by novel modifier PI31
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Papers (38):
  • Yan Wang, Yi Wang, Tomohiro Iriki, Eiichi Hashimoto, Maki Inami, Sota Hashimoto, Ayako Watanabe, Hiroshi Takano, Ryo Motosugi, Shoshiro Hirayama, et al. The DYT6 dystonia causative protein THAP1 is responsible for proteasome activity via PSMB5 transcriptional regulation. Nature communications. 2025. 16. 1. 1600-1600
  • Yuki Mori, Yoshino Akizuki, Rikuto Honda, Miyu Takao, Ayaka Tsuchimoto, Sota Hashimoto, Hiroaki Iio, Masakazu Kato, Ai Kaiho-Soma, Yasushi Saeki, et al. Intrinsic signaling pathways modulate targeted protein degradation. Nature communications. 2024. 15. 1. 5379-5379
  • Jun Hamazaki, Shigeo Murata. Relationships between protein degradation, cellular senescence, and organismal aging. Journal of biochemistry. 2024. 175. 5. 473-480
  • Tomohiro Iriki, Hiroaki Iio, Shu Yasuda, Shun Masuta, Masakazu Kato, Hidetaka Kosako, Shoshiro Hirayama, Akinori Endo, Fumiaki Ohtake, Mako Kamiya, et al. Senescent cells form nuclear foci that contain the 26S proteasome. Cell reports. 2023. 112880-112880
  • Xiangyu Zhou, Kengo Watanabe, Kazuhiro Morishita, Jun Hamazaki, Shigeo Murata, Isao Naguro, Hidenori Ichijo. Proteasomal regulation of ASK family kinases dictates cell fate under hyperosmotic stress. 2023
more...
MISC (10):
Education (2):
  • 2005 - 2008 Tokyo Metropolitan University
  • 2003 - 2005 Tokyo Metropolitan University
Professional career (1):
  • 理学博士 (首都大学東京)
Work history (3):
  • 2023/05 - 現在 The University of Tokyo Graduate School of Pharmaceutical Sciences Lecturer
  • 2008/09 - 2023/04 The University of Tokyo Graduate School of Pharmaceutical Sciences
  • 2008/04 - 2008/08 東京都臨床医学総合研究所 先端研究センター 日本学術振興会特別研究員PD
Association Membership(s) (1):
THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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