SUGA Hiroaki

Affiliation and department：

Research field (1)： Bioorganic chemistry

Research theme for competitive and other funds (29)：

2020 - 2025 Challenges to the remaining issues of therapeutically valuable pseudo-natural peptides and products
2022 - 2024 抗KRAS環状ペプチドファマコフォアの小型タンパク質へのラソグラフト体の創出
2016 - 2022 Redesigning Biosynthetic Machineries (International Activity Support Team)
2016 - 2021 Synthetic biology of pseudo-natural products by artificial in vitro biosynthesis
2016 - 2021 Redesigning Biosynthetic Machineries (Project Team)

2018 - 2019 ペプチドセレクションによる酵素ミミック創薬のための戦略

2016 - 2019 抗菌作用を発揮する大環状特殊ペプチドの発見と開発

2016 - 2019 中性子捕捉療法を指向したホウ素含有環状ペプチドの開発

2014 - 2019 Generation of minimal peptide catalysts based on the macrocyclic scaffold

2016 - 2018 チアゾール含有環状ペプチドの翻訳合成法

2015 - 2018 薬剤活性向上した大環状ペプチドを開発する新規戦略

2015 - 2018 Trial for determining the structure of CXCR7

2015 - 2017 Signal characteristics of heatero-receptor coupling and generation of artificial ligand

2014 - 2017 Innovation of chemiluminogenetics capable of noninvasive manipulation of biological functions deep inside body

2013 - 2017 Development of PPIs for a histone methyltransferase for leukemia therapy

2013 - 2017 Analyses of mechanism of action of a quorum sensing inhibitor by using real-time imaging system

2014 - 2016 プロリル-4-ヒドロキシダーゼをアイソフォーム選択的に阻害する大環状化合物の発見

2013 - 2016 チオオキシ主鎖骨格ペプチドの翻訳合成技術の開発

2013 - 2016 Keap1-Nrf2の相互作用を阻害する擬天然物特殊ペプチドのプロドラッグ化

2013 - 2016 低酸素誘導因子を阻害する特殊ペプチドの創出

2013 - 2015 Influenza viral hemagglutinin-targeted macrocyclic peptides as an antiviral agent

2011 - 2013 ペプチドーペプトイド複合骨格をもつエピゲノム酵素阻害剤の発見

2009 - 2013 Non-standard peptide-probe discovery

2011 - 2012 Development of novel methods for identifying antibiofilm agents against multidrug-resistant Acinetobacter baumannii

2009 - 2009 擬天然物の翻訳プログラム合成と薬剤探索

2007 - 2009 Persistent biofilms in urinary tract infections -the development of novel methods for identifying antibiofilm agents-

2006 - 2008 Pseudomonas aeruginosa biofilms in urinary tract infections-the development of novelmethods for the search of antibiofilm agents-

2004 - 2008 Generation of ribozymes that catalyze fatty acid biosynthesis

2005 - 2007 The study on control technique of oral biofilms using a quorum sensing circuit

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Papers (286)：

Nichole Marcela Rojas-Chaverra, Ryu Imamura, Hiroki Sato, Toby Passioura, Emiko Mihara, Tatsunori Nishimura, Junichi Takagi, Hiroaki Suga, Kunio Matsumoto, Katsuya Sakai. A cyclic peptide-grafted Fc with hepatocyte growth factor functionality ameliorates hepatic fibrosis in a non-alcoholic steatohepatitis mouse model. iScience. 2024. 27. 8. 110426-110426
Sumika Inoue, Dinh Thanh Nguyen, Keisuke Hamada, Rika Okuma, Chikako Okada, Masahiro Okada, Ikuro Abe, Toru Sengoku, Yuki Goto, Hiroaki Suga. De Novo Discovery of Pseudo-Natural Prenylated Macrocyclic Peptide Ligands. Angewandte Chemie International Edition. 2024
Alexander A Vinogradov, Yue Zhang, Keisuke Hamada, Shunsuke Kobayashi, Kazuhiro Ogata, Toru Sengoku, Yuki Goto, Hiroaki Suga. A Compact Reprogrammed Genetic Code for De Novo Discovery of Proteolytically Stable Thiopeptides. Journal of the American Chemical Society. 2024. 146. 12. 8058-8070
Wei Lu, Naohiro Terasaka, Yuriko Sakaguchi, Takeo Suzuki, Tsutomu Suzuki, Hiroaki Suga. An anticodon-sensing T-boxzyme generates the elongator nonproteinogenic aminoacyl-tRNA in situ of a custom-made translation system for incorporation. Nucleic Acids Research. 2024
Takashi Miura, Tika R Malla, Lennart Brewitz, Anthony Tumber, Eidarus Salah, Kang Ju Lee, Naohiro Terasaka, C David Owen, Claire Strain-Damerell, Petra Lukacik, et al. Cyclic β2,3-amino acids improve the serum stability of macrocyclic peptide inhibitors targeting the SARS-CoV-2 main protease. Bulletin of the Chemical Society of Japan. 2024

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MISC (58)：

Takayuki Katoh, Hiroaki Suga. Development of bioactive foldamers using ribosomally synthesized nonstandard peptide libraries#. Bulletin of the Chemical Society of Japan. 2021. 94. 2. 549-557
Alexander A. Vinogradov, Hiroaki Suga. Introduction to Thiopeptides: Biological Activity, Biosynthesis, and Strategies for Functional Reprogramming. Cell Chemical Biology. 2020. 27. 8. 1032-1051
Koki Shinbara, Wenyu Liu, Renier Herman Pieter van Neer, Takayuki Katoh, Hiroaki Suga. Methodologies for Backbone Macrocyclic Peptide Synthesis Compatible With Screening Technologies. Frontiers in Chemistry. 2020. 8
尾崎太郎, 尾崎太郎, 菅井佳宣, 浅水俊平, 尾仲宏康, 後藤佑樹, 菅裕明, 池田治生. Dissection of goadsporin biosynthetic machinery by in vitro reconstitution leading to in vivo production of designer analogues. Institute for Fermentation, Osaka. Research Communications. 2018. 32
菅井佳宣, 菅井佳宣, 尾崎太郎, 尾崎太郎, 浅水俊平, 尾仲宏康, 菅裕明, 後藤佑樹. Analysis of lanthipeptide biosynthetic enzymes responsible for formation of novel goadionin structure. Institute for Fermentation, Osaka. Research Communications. 2018. 32

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Patents (38)：

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