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J-GLOBAL ID：201601000813116344 Update date: Mar. 26, 2025

Takasato Minoru

タカサトミノル | Takasato Minoru

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Affiliation and department：
Job title： Team Leader
Other affiliations (2)：

Kyoto University Graduate School of Biostudies Visiting Associate Professor
Osaka University Graduate School of Medicine Visiting Professor

Research field (3)： Biomedical engineering , Medical biochemistry , Developmental biology

Research keywords (6)： Kidney Organoid , Organoid , Mesoderm Development , Kidney Development , Pluripotent Stem Cells , Directed Differentiation

Research theme for competitive and other funds (12)：

2021 - 2024 腎臓、尿管、膀胱を含む尿路系組織のインビトロ一体構築
2021 - 2024 A fundamental methodology reproducing epithelial-mesenchymal interaction to create further advanced tissues of endodermal organs
2021 - 2023 腎ネフロン形成現象を司るリーダー細胞の同定と特異性の理解
2020 - 2023 iPS細胞由来腎臓オルガノイドを用いた小児ネフローゼ症候群の発症機序の解明
2019 - 2021 Investigation of environmental singularity using a realtime evaluating system of MET events.

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Papers (77)：

Yoshiki Sahara, Chie Fukui, Yuki Kuniyoshi, Minoru Takasato. Proximal tubule cell maturation rate and function are controlled by PPARα signaling in kidney organoids. communications biology. 2024. 7. 1. 1532-1545
Yuichiro Kitai, Naoya Toriu, Takahisa Yoshikawa, Yoshiki Sahara, Sonoko Kinjo, Yoko Shimizu, Yuki Sato, Akiko Oguchi, Ryo Yamada, Makiko Kondo, et al. Female sex hormones inversely regulate acute kidney disease susceptibility throughout life. Kidney International. 2024
Kensuke Yabuuchi, Tomoko Horinouchi, Tomohiko Yamamura, Kandai Nozu, Minoru Takasato. In vitro induction of prostate buds from murine urogenital epithelium in the absence of mesenchymal cells. Genes to Cells. 2024
Cheng Ma, Ramin Banan Sadeghian, Ryosuke Negoro, Kazuya Fujimoto, Toshikazu Araoka, Naoki Ishiguro, Minoru Takasato, Ryuji Yokokawa. Efficient proximal tubule-on-chip model from hiPSC-derived kidney organoids for functional analysis of renal transporters. iScience. 2024. 27. 9. 110760-110760
高里実. 生命進化からみる腎臓オルガノイド研究. 実験医学増刊オルガノイドがもたらすライフサイエンス革命. 2024. 42. 5. 848-853

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MISC (3)：

荒井優, 荒井優, 安瑜利, 高崎真美, 若林玲実, BORISOVA Evgeniia, 李景げつ, 高見美帆, 高里実, 早田匡芳, et al. ヒトiPS細胞からの腎臓オルガノイドを用いた遺伝性腎疾患病態モデルの作製. 日本再生医療学会総会(Web). 2020. 19th
A. Mallett, C. Patel, J. Crawford, S. Alexander, B. Bennetts, H. Mccarthy, C. Quinlan, B. Maier, P. Er, M. Takasato, et al. MASSIVELY PARALLEL SEQUENCING (MPS) AND FUNCTIONAL GENOMICS CAN ACHIEVE GENETIC DIAGNOSIS IN UNRESOLVED CASES OF GENETIC RENAL DISEASE (GRD). NEPHROLOGY. 2016. 21. 88-88
M. H. Little, J. M. Vanslambrouck, M. Takasato, J. Li, N. Suhaimi, P. X. Er, H. Chiu. TRANSCRIPTIONAL REPROGRAMMING AND DIRECTED DIFFENRENTIATION OF PLURIPOTENT STEM CELLS: ALTERNATIVE OPTIONS FOR REGENERATING KIDNEY. JOURNAL OF GENE MEDICINE. 2015. 17. 8-9. 182-183

Lectures and oral presentations (125)：

Generation of the urinary tract organoids from human pluripotent stem cells
(Generation of the urinary tract organoids from human pluripotent stem cells 2025)
腎臓オルガノイドにおけるin vitro組織成熟化
(第24回日本再生医療学会総会 2025)
Enhancement of Bladder Organoids Through Interaction Between Urotheial Epithelium and Visceral Mesenchyme
(2025 RIKEN BDR-CuSTOM Joint Organoid Symposium 2025)
ヒトiPS細胞から造る膀胱組織
(関西のユニークな研究シーズ大集合!~再生医療・遺伝子治療編~ 2024)
Proximal tubule cell maturation rate and function are controlled by PPARα signaling in kidney organoids
(2024 International Forum on Drug Discovery and Development 2024)

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Education (2)：

- 2008 東京大学大学院理学系研究科生物科学専攻修了
- 2002 The University of Tokyo Faculty of Science Department of Biological Sciences

Professional career (1)：

Ph.D (The University of Tokyo)

Work history (4)：

2018/04 - 現在 RIKEN Center for Biosystems Dynamics Research Team Leader
2016/08 - 2018/03 RIKEN Center for Developmental Biology Team Leader
2015 - 2016 Murdoch Childrens Research Institute Senior Research Officer
2009 - 2014 The University of Queensland Research Officer

Committee career (2)：

2019/03 - 2020/03 第19回日本再生医療学会総会プログラム委員
2017/09 - 2018/10 第5回国際組織工学・再生医療学会世界会議2018-京都プログラム委員

Awards (9)：

2018/04 - MEXT The Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology The Young Scientists’ Prize
2016/08 - Australian Museum Eureka Prize for Scientific Research Scientific Research
2016/06 - International Society for Stem Cell Research Travel Award
2014/06 - International Society for Stem Cell Research Travel Award
2014/06 - International Society for Stem Cell Research Betty Jean Ogawa Memorial Award

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Association Membership(s) (6)：

Japanese Society of Nephrology , Japanese Society for Regenerative Medicine , JAPANESE SOCIETY OF DEVELOPMENTAL BIOLOGISTS , American society of nephrology , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , International society for stem cell research

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