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J-GLOBAL ID：201601004024603635 Update date: Nov. 07, 2024

Susumu Nakae

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Affiliation and department：
Job title：教授

Research field (4)： Allergies and connective tissue disease , Laboratory animal science , Animals: biochemistry, physiology, behavioral science , Immunology

Research keywords (7)： mast cell , Th17 cells , Interleukin-33 , Interleukin-17 , Mouse models of human diseases , allergy , Cytokine

Research theme for competitive and other funds (33)：

2023 - 2026 Influence of reduced physical activity on the pathophysiology of asthma
2021 - 2024 Elucidation of respiratory diseases through analyses on the beating of tracheal cilia and resulting fluid flow
2021 - 2024 A
2018 - 2022 環境微粒子キチンに対する生体応答機構の解明
2018 - 2021 上皮バリア機能の破壊に伴う炎症の誘導に関わるサイトカインの機能解析

2016 - 2018 The role of ILC2 in allergic conjunctivitis

2015 - 2018 Molecular mechanisms involved in epicutaneous sensitization

2015 - 2018 Bicuspidalization of the native tricuspid aortic valve using a miniature pig

2014 - 2018 Development of analytical tools for elucidating functions of epidermal gd T cells

2014 - 2018 Patient-specific assessment of hemodynamics by computational fluid dynamics and gene expression profiling in patients with bicuspid aortopathy.

2016 - 2017 Analysis of signal transduction mechanisms by chitin through Chitinase-like proteins.

2014 - 2017 Regulation of tissue fibrosis and natural helper cells in ocular atopy

2014 - 2017 Chitin-mediated IL-33 induces breakdown of immune tolerance by excessive IL-1b production by DCs, causing aggravation of murine asthma

2015 - 2016 Identification of chitin binding protein(s) and analysis of cellular signal transduction by stimulation of chitin.

2013 - 2016 Efficacy of closed-circuit cardiopulmonary bypass system assessed by gene expression profiling

2011 - 2016 炎症誘導因子による炎症抑制機構の解明と慢性炎症制御技術基盤の確立

2013 - 2015 The roles of Alarmin for the pathophysiology of Atopic Retinal Detachment

2012 - 2015 Pathophysiological Analysis of Atopic Glaucoma

2012 - 2015 Study on the regulation of immune responses by a novel IL-6/IL-12 family cytokine

2012 - 2015 Integrated Analysis of microRNA and mRNA Gene Expression Profiling for Non-syndromic Acute Type A Aortic Dissection

2012 - 2015 新規アレルギーモデルマウスの確立とその解析

2012 - 2014 Atopic keratoconjunctivitis and natural helper cell

2011 - 2014 Pathogenesis and mechanisms of protease antigen-induced innate-type airway inflammation

2012 - 2013 IL-33とIL-33受容体の機能解析

2011 - 2013 Development of analysis tools for epidermal gdT cells, and its functional analysis

2011 - 2013 The role of Dok adaptors in pulmonary disorders

2011 - 2012 IL-17受容体の細胞内情報伝達経路の解明

2009 - 2012 新しい制御性T細胞体外増幅法による喘息治療法の開発

2010 - 2012 Pathological analysis of skin fibrosis, focused on type 2 innate immune lymphoid cells

2010 - 2012 Study on schistosome's suppressive mechanisms against Th17-type inflammation

2009 - 2011 接触型過敏症応答におけるIL-17ファミリーサイトカインIL-25の役割

2010 - 2011 Screening of house dust mite allergy vaccine candidates using full-length cDNA library.

2009 - 2011 A negative feedback mechanism controled by IL-33 and mast cells.

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Papers (201)：

Takafumi Numata, Masashi Ikutani, Ken Arae, Tatsukuni Ohno, Koki Okada, Takayuki Yoshimoto, Katsuko Sudo, Hajime Suto, Ko Okumura, Hirohisa Saito, et al. IL-10 promotes Th17 cell differentiation by enhancing STAT1-dependent IL-6 production via IgE-stimulated mast cells. Scientific reports. 2024. 14. 1. 26706-26706
Jeong-Hwan Yoon, Eunjin Bae, Yasuo Nagafuchi, Katsuko Sudo, Jin Soo Han, Seok Hee Park, Susumu Nakae, Tadashi Yamashita, Ji Hyeon Ju, Isao Matsumoto, et al. Repression of SMAD3 by STAT3 and c-Ski induces conventional dendritic cell differentiation. Life science alliance. 2024. 7. 9
Satoshi Hanzawa, Makiko Sugiura, Susumu Nakae, Masahiro Masuo, Hideaki Morita, Kenji Matsumoto, Kazuyoshi Takeda, Ko Okumura, Masataka Nakamura, Tatsukuni Ohno, et al. The Prostaglandin D2 Receptor CRTH2 Contributes to Airway Hyperresponsiveness during Airway Inflammation Induced by Sensitization without an Adjuvant in Mice. International archives of allergy and immunology. 2024. 1-9
Kenichiro Motomura, Hideaki Morita, Naoko Okada, Akio Matsuda, Susumu Nakae, Mikiya Fujieda, Haruhiko Sago, Hirohisa Saito, Kenji Matsumoto. Comprehensive Analysis of the Expression and Functions of Pattern Recognition Receptors in Differentiated Cytotrophoblasts Derived from Term Human Placentas. Journal of immunology (Baltimore, Md. : 1950). 2023. 210. 10. 1552-1563
Kyoko Saito, Keisuke Orimo, Terufumi Kubo, Masato Tamari, Ayako Yamada, Kenichiro Motomura, Hiroki Sugiyama, Ryo Matsuoka, Naoko Nagano, Yuka Hayashi, et al. Laundry detergents and surfactants-induced eosinophilic airway inflammation by increasing IL-33 expression and activating ILC2s. Allergy. 2023

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MISC (65)：

梅村正幸, 儀間香南子, 高江洲義一, 中江進, 岩倉洋一郎, 松崎吾朗. マイコバクテリア感染肺に誘導されるIL-17A産生細胞の多様性. 日本インターフェロン・サイトカイン学会学術集会抄録集. 2018. 83. 96
Jeong-Hwan Yoon, Eunjin Bae, Katsuko Sudo, Seok Hee Park, Michael Weinstein, Sungmi Park, Jae-Han Jeon, Susumu Nakae, In-Kyu Lee, Ji Hyeon Ju, et al. Repression of SMAD3 by STAT3 and c-SKI is essential for conventional dendritic cell differentiation. CYTOKINE. 2017. 100. 54-55
高井敏朗, 清村咲子, 飯田秀雄, 丸山奈津子, 越智啓乃, 上條清嗣, 西岡いずみ, 原むつ子, 松田彰, 斎藤博久, et al. 【経皮感作と腸管免疫寛容】アレルゲンのプロテアーゼ活性と機械的な皮膚バリア損傷はマウスにおいて経皮的アレルゲン感作を増強する. 臨床免疫・アレルギー科. 2017. 68. 5. 515-522
Hideaki Morita, Susumu Nakae, Cezmi A. Akdis, Hirohisa Saito, Kenji Matsumoto. Mast Cells Suppress IL-33 Induced Innate-Type Allergic Airway Inflammation By Promoting Regulatory T Cell Expansion. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017. 139. 2. AB165-AB165
Toyama Sumika, Naoko Okada, Matsuda Akio, Saito Hirohisa, Nakae Susumu, Karasuyama Hajime, Matsumoto Kenji. A Novel Protease, PRSS33 (serine protease 33), Is Specifically and Constitutively Expressed in Eosinophils. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017. 139. 2. AB163

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Education (1)：

1999 - 2002 The University of Tokyo Graduate School of Agricultural and Life Sciences Department of Animal Resource Sciences

Professional career (1)：

農学 (東京大学)

Work history (9)：

2020/04 - 現在 Hiroshima University
2019/10 - 2020/03 Japan Science and Technology Agency
2019/04 - 2019/09 東京大学医科学研究所特任研究員
2012/04 - 2019/03 The Institute of Medical Science, The University of Tokyo Laboratory of Systems Biology, Center for Experimental Medicine and Systems Biology Associate Professor
2010/01 - 2012/03 The Institute of Medical Science, The University of Tokyo Frontier Research Initiative Project Associate Professor

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Awards (7)：

2017 - Clarivate Analytics Highly Cited Researchers
2016 - Thomson Reuters Highly Cited Researchers
2015 - Thomson Reuters Highly Cited Researchers
2014 - Thomson Reuters Highly Cited Researchers
2011/11 - 公益財団法人日本アレルギー協会第21回アボットジャパン・アレルギー学術奨励賞

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Association Membership(s) (4)：

Collegium Internationale Allergologicum , JAPANESE ASSOCIATION FOR LABORATORY ANIMAL SCIENCE , JAPANESE SOCIETY OF ALLERGOLOGY , THE JAPANESE SOCIETY FOR IMMUNOLOGY

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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