Research field (4):
Tumor biology
, Medical biochemistry
, Pathobiochemistry
, Experimental pathology
Research theme for competitive and other funds (5):
2022 - 2025 アクチビン・ミオスタチン阻害剤FSTL3製剤の筋萎縮症モデルでの評価
2019 - 2023 Development of a selective inhibitor of Activin and its application in a cancer-bearing mouse model
2017 - 2022 Molecular mechanisms of cell differentiation and diversity by TGF-beta family members
2017 - 2019 Roles of bone morphogenetic protein (BMP) in pluripotency and tumorigenesis
2016 - 2018 Exploring the role of BMP signaling in cell differentiation/cell-fate decision and plasticity
Papers (31):
Tomohiro Ogami, Yusuke Tamura, Kim Toss, Keiko Yuki, Masato Morikawa, Shuichi Tsutsumi, Hiroyuki Aburatani, Keiji Miyazawa, Kohei Miyazono, Daizo Koinuma. MAB21L4 regulates the TGF-β-induced expression of target genes in epidermal keratinocytes. The Journal of Biochemistry. 2022. 171. 4. 399-410
Ryo Tanabe, Kohei Miyazono, Tomoki Todo, Nobuhito Saito, Caname Iwata, Akiyoshi Komuro, Satoshi Sakai, Erna Raja, Daizo Koinuma, Masato Morikawa, et al. PRRX1 induced by BMP signaling decreases tumorigenesis by epigenetically regulating glioma-initiating cell properties via DNA methyltransferase 3A. Molecular Oncology. 2022. 16. 1. 269-288
Masato Morikawa. Preparation of monovalent follistatin-like 3-Fc-fusion protein and evaluation of its effects on muscle mass in mice. STAR protocols. 2021. 2. 4. 100839
Yusuke Tamura, Masato Morikawa, Ryo Tanabe, Kohei Miyazono, Daizo Koinuma. Anti-pyroptotic function of TGF-β is suppressed by a synthetic dsRNA analogue in triple negative breast cancer cells. Molecular Oncology. 2021. 15. 5. 1289-1307
Takayuki Ozawa, Masato Morikawa, Yasuyuki Morishita, Kazuki Ogikubo, Fumiko Itoh, Daizo Koinuma, Per-Åke Nygren, Kohei Miyazono. Systemic administration of monovalent follistatin-like 3-Fc-fusion protein increases muscle mass in mice. iScience. 2021. 24. 5. 102488-102488
荻窪 一貴, 西田 純, 高橋 恵生, 森川 真大, 江幡 正悟, 鯉沼 代造, 宮園 浩平. エピゲノム変化を介したトリプルネガティブ乳がん高悪性化機構の解明(Elucidation of the mechanisms of epigenetic change-mediated malignant transformation of triple-negative breast cancer). 日本癌学会総会記事. 2023. 82回. 1604-1604
森川真大, 宮園浩平. Development of FSTL3-based therapeutics as a selective antagonist of activin and myostatin. 月刊メディカル・サイエンス・ダイジェスト. 2023. 49. 11
鯉沼代造, 田村佑介, 森川真大, 森川真大, 堤修一, 田邉諒, 田邉諒, 宮園浩平, 宮園浩平. PolyI:C attenuates TGF-β signaling to induce pyroptotic and cytostatic programs in triple-negative breast cancer. 日本癌学会学術総会抄録集(Web). 2022. 81st
荻窪一貴, 西田純, 西田純, 高橋恵生, 高橋恵生, 森川真大, 森川真大, 江幡正悟, 江幡正悟, 鯉沼代造, et al. Identification of the mechanisms of malignant progression of triple-negative breast cancer via epigenetic changes. 日本癌学会学術総会抄録集(Web). 2022. 81st
2007 - 2011 The University of Tokyo Graduate School of Medicine
1998 - 2004 The University of Tokyo Faculty of Medicine School of Medicine
Professional career (1):
Ph.D. in Medicine (The University of Tokyo)
Work history (4):
2022/04 - 現在 Teikyo University Advanced Comprehensive Research Organization Associate Professor
2016/01 - 2022/03 The University of Tokyo Graduate School of Medicine Assistant Professor
2012/04 - 2015/12 Uppsala University Ludwig Institute for Cancer Research Post-doctoral fellow
2011/04 - 2012/03 The University of Tokyo Graduate School of Medicine Project Assistant Professor
Awards (9):
2024/10 - 内藤記念科学振興財団 2024年度内藤記念科学奨励金・研究助成
2023/11 - Takeda Science Foundation Research Grant
2023/11 - Mochida Memorial Foundation for Medical and Pharmaceutical Research Research Grant
2021/07 - virtual FASEB Science Research Conference, The TGF-β Superfamily Conference: Signaling in Development and Disease Award for the Best Short Talk
2014/05 - TGF-β meeting in Leiden 2014 Best Poster Award
2013/04 - ITO Genboku and SAGARA Chian Memorial Scholarship
2012/08 - TGF-β meeting in Leiden 2012 Best Poster Award
2011/05 - 9th Hereditary Hemorrhagic Telangiectasia (HHT) Scientific Conference Award for the Best Oral Presentation by a Young Investigator
2011/02 - Kanae Foundation Research Abroad
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Association Membership(s) (4):
日本内科学会
, THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
, THE JAPANESE BIOCHEMICAL SOCIETY
, THE JAPANESE CANCER ASSOCIATION