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J-GLOBAL ID：201601007159418527 Update date: Mar. 28, 2025

Ueda Mitsuharu

ウエダミツハル | Ueda Mitsuharu

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Affiliation and department：
Other affiliations (3)：

Kumamoto University
Kumamoto University
Kumamoto University

Homepage URL (1)： http://kumadai-neurology.com/class

Research field (5)： Internal medicine - General , Pathobiochemistry , Neuropathology , Genetics , Neurology

Research keywords (2)：トランスサイレチン , Amyloidosis

Research theme for competitive and other funds (30)：

2024 - 2027 脳脈絡叢を標的とした革新的な中枢神経アミロイドーシス治療法の開発
2024 - 2027 新型アミロイドーシスの多角的アプローチによる検査システムの構築および病態解析
2022 - 2026 統合的MRI解析を用いたCOVID-19神経学的後遺症に関する脳病態解明
2022 - 2025 ATTR amyloid clearance for definitive therapy
2022 - 2025 小血管の老化から解明するトランスサイレチンアミロイドーシスの病態

2022 - 2025 The disease of 21 century: Development of a novel therapy for ATTR amyloidosis based on the pathogenesis of amyloid formation mechanism

2022 - 2025 Development of ATTR amyloid clearance therapies

2021 - 2025 難病医療における遺伝ケアネットワークの構築

2023 - 2025 新・標的分子と新・神経機能解析法を用いた糖脂質代謝異常症の薬剤開発

2021 - 2024 Biological molecules enhancing/inhibiting amyloid fibril formation: Integration of in vitro experiment and proteomic analysis

2021 - 2024 Investigation of the pathogenesis and diagnostic method in knee osteoarthritis related to a novel amyloid

2020 - 2023 Establishment of surrogate markers and indicators for disease onset to maximize the effect of novel disease-modifying therapies for TTR-FAP

2021 - 2023 新技術と新治療コンセプトに基づく先天代謝異常症に対する治療薬開発

2021 - 2023 遺伝性トランスサイレチンアミロイドーシスの革新的治療を最適化する病態評価法

2019 - 2022 The trump card for aging related TTR amyloidosis using natural compounds

2019 - 2022 Proteomics analysis for amyloid in hereditary ATTR cerebral amyloid angiopathy targeting coexistence protein

2019 - 2022 Analysis of extracellular matrix aging in the pathogenesis of TTR amyloidosis

2019 - 2022 Elucidating mechanisms for metastasis and recurrence through a tumor cell dormancy model

2018 - 2021 Proposal of pre-borderline neuropathy as a new disease entity and construction of novel ultra-early diagnosis methods for detecting the disease

2018 - 2021 Screening methods to discover ATTR amyloid disrupters

2016 - 2019 The risk assessment and biological defense mechanism for high methylmercury exposure group eating whale and tuna

2015 - 2019 Next generation type composite antibody therapy for TTR amyloidosis

2015 - 2018 Novel experimental model of TTR amyloidosis using TTR fragments

2015 - 2017 Control of amyloid neuropathy from the aspect of inflammation

2013 - 2015 Fragmentations of transthyretin in familial amyloid polyneuropathy

2012 - 2015 Early diagnosis and analyses of the pathogenesis for amyloidosis with all our previous investigations

2010 - 2012 Establishment of the new diagnostic procedure of oral cancer whichtargeted midkine and development of the therapy

2009 - 2011 Hepatocyte replacement therapy for familial amybidotic polyneuropathy combining iPS cells and gene-repair therapy

2009 - 2010 Metabolism of amyloid proteins and methods for detecting amyloid proteins

2007 - 2008 Novel methods for detection of amyloidogenic proteins and analyses of amyloid formation

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Papers (436)：

Yoshiki Sekijima, Mitsuharu Ueda, Kentaro Takahashi, Hiroaki Kitaoka. [Is neurofilament light chain useful as a disease progression marker for ATTRv amyloidosis? A literature review]. Rinsho shinkeigaku = Clinical neurology. 2025
David Adams, Jonas Wixner, Michael Polydefkis, John L Berk, Isabel M Conceição, Angela Dispenzieri, Amanda Peltier, Mitsuharu Ueda, Shaun Bender, Kelley Capocelli, et al. Five-Year Results With Patisiran for Hereditary Transthyretin Amyloidosis With Polyneuropathy: A Randomized Clinical Trial With Open-Label Extension. JAMA neurology. 2025. 82. 3. 228-236
Hironori Mizutani, Yohei Misumi, Kohei Hamanaka, Nozomu Tawara, Satoko Miyatake, Naomichi Matsumoto, Mitsuharu Ueda. A Case of Nebulin-Related Nemaline Myopathy With Asymmetric Distal Lower Limb Weakness. Cureus. 2025. 17. 2. e78945
Naoto Kuyama, Yasuhiro Izumiya, Seiji Takashio, Hiroki Usuku, Akihisa Tabira, Tetsuya Oguni, Masahiro Yamamoto, Kyoko Hirakawa, Masanobu Ishii, Noriaki Tabata, et al. Long-Term Effect of Tafamidis on Clinical Parameters and Prognostic Predictors in Patients With Transthyretin Amyloid Cardiomyopathy. Circulation journal : official journal of the Japanese Circulation Society. 2025. 89. 4. 421-431
山本和佳奈, 原田しずか, 水谷浩徳, 松原崇一朗, 中原圭一, 植田光晴. 膝蓋腱の軟部腫瘤が受診の契機となった脳腱黄色腫症の1例. 臨床神経学. 2025. 65. 1. 75-75

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MISC (818)：

中澤幹, 木庭新治, 余語萌, 鈴木憲史, 矢野怜, 松山高明, 金子堯一, 植田光晴, 新家俊郎. A Case of Hereditary Transthyretin Amyloidosis With Monoclonal Gammopathy of Undetermined Significance: A Case Report. 心臓. 2025. 57. 2
村上隼人, 水谷浩徳, 松原崇一朗, 進藤誠悟, 中島誠, 上谷浩之, 平井俊範, 植田光晴. Heavily T2Wiが診断に有用であった脊髄硬膜外動静脈瘻の1例. 臨床神経学. 2025. 65. 1. 72-72
俵望, 原健太朗, 永利知佳子, 藤本彰子, 石崎雅俊, 栗崎玲一, 西田泰斗, 前田寧, 上山秀嗣, 植田光晴. 髄液中好酸球増多を認めた抗LGI1抗体陽性自己免疫性脳炎の1例. 臨床神経学. 2025. 65. 1. 74-74
植田光晴. 【アミロイドーシスupdate】トランスサイレチンアミロイドーシスの診断と治療. 病理と臨床. 2024. 42. 11. 1116-1120
丸山サラディーニ恵子, 小池春樹, 植田光晴, 関島良樹, 安東由喜雄. 日本の非集積地における高齢発症遺伝性ATTRアミロイドーシスの早期診断のための提言. 臨床神経学. 2024. 64. 10. 708-713

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Patents (7)：

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Books (2)：

21世紀の疾患:神経関連アミロイドーシス
医学と看護社 2020 ISBN:9784909888075
最新アミロイドーシスのすべて : 診療ガイドライン2017とQ&A
医歯薬出版 2017 ISBN:9784263731758

Education (3)：

2003 - 2007 Kumamoto University Graduate School of Medical Sciences
1993 - 1999 Kumamoto University School of Medicine
1989 - 1992 山口県立下関西高等学校

Professional career (1)：

医学博士 (熊本大学)

Work history (10)：

2020/04 - 現在 Kumamoto University
2013/04 - 2020/03 Kumamoto University
2012/04 - 2013/03 熊本大学医学部付属病院中央検査部講師
2011/04 - 2012/12 インディアナ大学臨床病理学客員研究員
2007/04 - 2012/03 熊本大学大学院生命科学研究部病態情報解析学(臨床検査医学) 助教

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Committee career (10)：

2023 - 現在 International Society of Amyloidosis (ISA) Education committee member
2021 - 現在 International Society of Amyloidosis (ISA) Treatment of ATTR amyloidosis working group member
2021 - 現在 International Society of Amyloidosis (ISA) Tissue diagnosis of amyloidosis working group member
2021 - 2022 International Society of Amyloidosis (ISA) Membership committee member
厚労省難治性疾患政策研究事業アミロイドーシスに関する調査研究班分担研究者

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Awards (11)：

2019/03 - 平成30年度熊本医学会奨励賞(研究業績部門)
2018/03 - President Award. The XVIth International Symposium on Amyloidosis.
2018/01 - 平成29年度熊本大学神経内科同門会賞 Best Neuroscientist of the year.
2017/08 - 第28回日本末梢神経学会賞(基礎部門)
2014/11 - 平成26年度国立大学法人熊本大学医療活動表彰

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