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J-GLOBAL ID：201601009146057366 Update date: Apr. 03, 2025

Yamaguchi Shinpei

ヤマグチシンペイ | Yamaguchi Shinpei

Research field (3)： Laboratory animal science , Molecular biology , Developmental biology

Research keywords (9)：リプログラミング , DNAメチル化/脱メチル化 , 全能性 , 生殖細胞 , ゲノムインプリンティング , ES細胞 , 初期胚 , エピジェネティクス , 幹細胞

Research theme for competitive and other funds (6)：

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Papers (28)：

山口新平. Tet遺伝子による経世代エピゲノム制御. 月刊細胞. 2025. 2月号
Takamasa Ito, Musashi Kubiura-Ichimaru, Fumihito Miura, Shoji Tajima, M. Azim Surani, Takashi Ito, Shinpei Yamaguchi, Masako Tada. DNMT1 can induce primary germ layer differentiation through de novo DNA methylation. Genes to Cells. 2024
Riku Asano, Yohei Iizaka, Makoto Kashima, Yojiro Anzai, Shinpei Yamaguchi, Masako Tada. Unveiling dynamic hepatocyte plasticity in HepaRG cells with a dual CYP reporter system. PloS one. 2024. 19. 11. e0308694
Tomoka Katayama, Marina Takechi, Yamato Murata, Yuta Chigi, Shinpei Yamaguchi, Daiji Okamura. Development of a chemically disclosed serum-free medium for mouse pluripotent stem cells. Frontiers in bioengineering and biotechnology. 2024. 12. 1390386-1390386
Kit-Yeng Sheng, Toru Nakano, Shinpei Yamaguchi. A region-dependent allele-biased expression of Dopa decarboxylase in mouse brain. Frontiers in cell and developmental biology. 2022. 10. 1078927-1078927

MISC (15)：

Takahiro Maeda, Toru Nakano, Shinpei Yamaguchi. The physiological role and underlying mechanism of pericentric 5hmC in mouse primordial germ cell. MECHANISMS OF DEVELOPMENT. 2017. 145. S138-S138
Shinpei Yamaguchi, Takahiro Maeda, Toru Nakano. Molecular function of Tet1 in the epigenetic reprogramming through mouse germ cell development. GENES & GENETIC SYSTEMS. 2016. 91. 6. 331-331
Cheng Li-Tao, 長田翔伍, 平野邦生, 山口新平, 多田高. マウスiPS 細胞におけるPkd1 遺伝子の遺伝的異常の自発的正常化. 「第44 回日本発生生物学会総会」(2011.5.18-21. 那覇). 2011
平野邦生, 長田翔伍, 山口新平, 中川誠, 沖田圭介, 小寺秀俊, Justin Ainscough, 多田高. リン酸化阻害剤によるヒトとマウスiPS 細胞での異なるリプログラミング運命. 「第83 回日本遺伝学会総会」(2011.9.20-22, 京都). 2011
Nagata S, Yamaguchi S, Hirano K, Tada T. Reprogramming-susceptible somatic cells and reprogrammingoptimized \nSox2 expression. 「Symposium; “Nuclear Reprogramming: From germline to cloned animals” in 43rd Annual Meeting for the Japanese Society of Developmental Bioilogists」(2010.6.21-23, Kyoto, JP)(Invited). 2010

Books (2)：

誰でも再現できるNGS「前」サンプル調製プロトコール : 生物種別DNA、RNA、クロマチン、シングルセル調製の極意
羊土社 2024 ISBN:9784758122726
エピジェネティクス実験スタンダード : もう悩まない!ゲノム機能制御の読み解き方
羊土社 2017 ISBN:9784758101998

Lectures and oral presentations (24)：

Stress-induced transition of mouse ESCs to a two-cell embryo-like state
(The 5th Open Symposium of the New Academic Research Area Totipotency Program 2023)
Development of Tissue Cell Experimental Systems for Building Novel Drug Discovery Platforms
(12th Joint Seminar on Biomedical Sciences 2023)
Understanding the Role of Genomic Imprinting: Exploring the physiological functions and molecular mechanisms in mice and stem cell models
(2023 Symposium on Epigenetic Regulation 2023)
Epigenomes erased and imprinted in germ cells: regulatory mechanisms and functions.
(2023)
マウス脳におけるインプリンティングの可視化と機能解明
(第45回日本分子生物学会年会 2022)

Work history (7)：

2028/04 - 現在 Toho University Faculty of Science Department of Biology Associate Professor
2022/04 - 2025/03 Toho University Faculty of Science Department of Biology Lecturer
2015/06 - 2022/03 大阪大学大学院・医学系研究科
2012/08 - 2015/05 ハーバード医科大学・ボストン小児病院
2013/04 - 2015/03 日本学術振興会・海外特別研究員(兼任)

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Awards (3)：

2013/03 - Department of Genetics, Harvard Medical School Department of Genetics Retreat award at Retreat of Harvard Medical School
2013/03 - Best Poster award at Epigenetics & Chromatin Interactions and processes conference
2008/11 - 第23回内藤コンファレンスベストポスター賞

Association Membership(s) (3)：

日本分子生物学会 , 日本遺伝学会 , 日本エピジェネティクス研究会

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