Saito Junichi

サイトウジュンイチ | Saito Junichi

Affiliation and department：
Job title： Postdoctoral Fellow/Associate

Research field (3)： Fetal medicine/Pediatrics , Physiology , Cardiology

Research keywords (10)： vascular biology , vascular development , infant , vascular smooth muscle cells , vascular endothelial cells , elastic fibers , vascular remodeling , intimal thickening , ductus arteriosus , mechanobiology

Research theme for competitive and other funds (10)：

2024 - 2026 NIH Pathway to Independence Award (K99)
2023 - 2025 AHA Postdoctoral Fellowship (declined; overlap with AHA/CHF Postdoctoral Fellowship)
2023 - 2024 AHA/CHF Postdoctoral Fellowship
2022 - 2023 JSPS Overseas Research Fellowship
2018 - 2021 How to predict the collapse of homeostasis in circulatory regulation

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Papers (21)：

Fatima Z. Saddouk, Andrew P. Kuzemczak, Junichi Saito, Daniel M. Greif. Endothelial HIFα-PDGF-B to smooth muscle Beclin1 signaling sustains pathological muscularization in pulmonary hypertension. JCI Insight. 2024. e162449
Junichi Saito, Jui M. Dave, Freddy Duarte Lau, Daniel M. Greif. Presenilin-1 in smooth muscle cells facilitates hypermuscularization in elastin aortopathy. iScience. 2024. 27. 1. 108636
Tomoyuki Kojima, Takashi Nakamura, Junichi Saito, Yuko Hidaka, Taisuke Akimoto, Hana Inoue, Christian Nanga Chick, Toyonobu Usuki, Makoto Kaneko, Etsuko Miyagi, et al. Hydrostatic pressure under hypoxia facilitates fabrication of tissue-engineered vascular grafts derived from human vascular smooth muscle cells in vitro. Acta biomaterialia. 2023. 171. 209-222
Utako Yokoyama, Sayuki Oka, Junichi Saito. Molecular mechanisms regulating extracellular matrix-mediated remodeling in the ductus arteriosus. Seminars in Perinatology. 2023. 47. 2. 151716-151716
Jui M. Dave, Raja Chakraborty, Aglaia Ntokou, Junichi Saito, Fatima Z. Saddouk, Zhonghui Feng, Ashish Misra, George Tellides, Robert K. Riemer, Zsolt Urban, et al. JAGGED1/NOTCH3 activation promotes aortic hypermuscularization and stenosis in elastin deficiency. The Journal of Clinical Investigation. 2022. 132. 5. e142338

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MISC (18)：

伊藤智子, 横山詩子, 横山詩子, 中川路太一, 齋藤純一, 二町尚樹, 益田宗孝, 麻生俊英, 石川義弘. 内皮細胞が誘導する一方向性平滑筋細胞遊走が動脈管内膜肥厚を形成する. 日本小児循環器学会雑誌. 2019. 35. Supplement 1. s1.167-167
釼持孝博, 釼持孝博, 横山詩子, 齋藤純一, 伊藤智子, 魚住梓, 岩崎志穂, 西巻滋, 関和男, 石川義弘. ラット母体への分娩前ベタメタゾン投与が動脈管内膜肥厚へ与える作用の検討. 日本新生児成育医学会雑誌. 2018. 30. 3. 608-608
齋藤純一, 横山詩子, 益田宗孝, 麻生俊英, 石川義弘. 小児循環器疾患の基礎研究から臨床への応用動脈管閉鎖における内皮機能の役割. 日本小児循環器学会雑誌. 2018. 34. Suppl.1. s1-122
石川義弘, 横山詩子, 斎藤純一, 金子真. 心血管のトランスレーショナルリサーチ周期加圧培養法による人工血管の作成. 日本循環制御医学会総会プログラム・抄録集. 2018. 39回. 22-22
横山詩子, 齋藤純一, 石川義弘. The role of tissue plasminogen activator in closure of the ductus arteriosus. 日本血栓止血学会誌. 2018. 29. 5. 495-497(J-STAGE)

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Books (6)：

Expert Opinion on Pediatric Pharmacotherapy
Tokyo Igakusha 2023
The Vasculome: From Many to One. Out to the tissues: the arterial side.
Elsevier 2022 ISBN:9780128225462
Diagnosis and Treatment Based on Pathophysiology of Pediatric Diseases
Tokyo Igakusha 2020
Molecular Disease and Pulmonary Hypertension
Springer 2020 ISBN:9789811511851
Guyton and Hall Textbook of Medical Physiology Thirteen edition
ELSEVIER JAPAN 2018 ISBN:9784860347741

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Lectures and oral presentations (26)：

Sphingosine kinase 1 is integral for elastin deficiency-induced arterial muscularization
(The 101st Annual Meeting of The Physiological Society of Japan 2024)
Presenilin 1 Deletion in Smooth Muscle Cells Ameliorates Hypermuscularization and Stenosis in Elastin Aortopathy.
(American Heart Association Scientific Sessions 2023 2023)
Transcriptome analysis reveals gene expression differences between the closing ductus arteriosus and the patent ductus arteriosus in humans
(The 57th Annual Meeting of Japanese Society of Pediatric Cardiology and Cardiac Surgery 2021)
Role of endothelial cells in the ductus arteriosus remodeling
(The 3rd Taiwan-Korea-Japan Joint Congress on Neonatology 2019)
Tissue-type plasminogen activator contributes to remodeling of the rat ductus arteriosus
(The 64th Japan Society for Neonatal Health and Development 2019)

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Professional career (1)：

MD, PhD

Work history (1)：

2019/04 - 現在 Yale Cardiovascular Research Center, Yale University Depts of Cardiovascular Medicine Postdoctoral Fellow/Associate

Awards (15)：

2024/04 - NIH/NHLBI NIH Pathway to Independence Award (K99/R00)
2024/03 - The Physiological Society of Japan Promotion Award of the Physiological Society of Japan
2023/11 - American Heart Association Finalist, Young Hearts Early Career Investigator Award
2023/01 - Children's Heart Foundation and American Heart Association Congenital Heart Defect Research Award
2022/12 - American Heart Association AHA Postdoctoral Fellowship

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Association Membership(s) (9)：

Janeway Society, Yale University School of Medicine , American Physical Society , The Physiological Society of Japan , American Heart Association , The Japanese Circulation Society , Japanese Society of Pediatric Cardiology and Cardiac Surgery , Japan Society for Neonatal Health and Development , Japan Society of Perinatal and Neonatal Medicine , Japan Pediatric Society

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