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J-GLOBAL ID：201601009765937109 Update date: Feb. 09, 2025

Saito Junichi

サイトウジュンイチ | Saito Junichi

Affiliation and department：
Job title： Postdoctoral Fellow/Associate

Research field (3)： Fetal medicine/Pediatrics , Physiology , Cardiology

Research keywords (10)： vascular biology , vascular development , infant , vascular smooth muscle cells , vascular endothelial cells , elastic fibers , vascular remodeling , intimal thickening , ductus arteriosus , mechanobiology

Research theme for competitive and other funds (10)：

2024 - 2026 NIH Pathway to Independence Award (K99)
2023 - 2025 AHA Postdoctoral Fellowship (declined; overlap with AHA/CHF Postdoctoral Fellowship)
2023 - 2024 AHA/CHF Postdoctoral Fellowship
2022 - 2023 JSPS Overseas Research Fellowship
2018 - 2021 How to predict the collapse of homeostasis in circulatory regulation

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Papers (42)：

Junichi Saito, Jun Shibasaki, Kouji Yamamoto, Maya Fujita, Katsuaki Toyoshima. Predictive value of serum interleukin-6 for neonatal encephalopathy outcomes. Journal of Neonatal-Perinatal Medicine. 2024
Jui M. Dave, Raja Chakraborty, Alex Agyemang, Aglaia Ntokou, Junichi Saito, Praveen Ballabh, Kathleen A. Martin, Daniel M. Greif. Loss of TGFβ-mediated repression of angiopoietin-2 in pericytes underlies germinal matrix hemorrhage pathogenesis. Stroke. 2024
Fatima Z. Saddouk, Andrew P. Kuzemczak, Junichi Saito, Daniel M. Greif. Endothelial HIFα-PDGF-B to smooth muscle Beclin1 signaling sustains pathological muscularization in pulmonary hypertension. JCI Insight. 2024. e162449
Junichi Saito, Jui M. Dave, Freddy Duarte Lau, Daniel M. Greif. Presenilin-1 in smooth muscle cells facilitates hypermuscularization in elastin aortopathy. iScience. 2024. 27. 1. 108636
Tomoyuki Kojima, Takashi Nakamura, Junichi Saito, Yuko Hidaka, Taisuke Akimoto, Hana Inoue, Christian Nanga Chick, Toyonobu Usuki, Makoto Kaneko, Etsuko Miyagi, et al. Hydrostatic pressure under hypoxia facilitates fabrication of tissue-engineered vascular grafts derived from human vascular smooth muscle cells in vitro. Acta biomaterialia. 2023. 171. 209-222

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MISC (22)：

Junichi Saito, Jui Dave, Inamul Kabir, Eunate Gallardo-Vara, Timothy Hla, Daniel Greif. Sphingosine kinase 1 is integral for elastin deficiency-induced arterial muscularization. Circulation. 2024. 150. Suppl_1. A4120623
Junichi Saito, Jui M. Dave, Freddy D Lau, Daniel M. Greif. Presenilin 1 Deletion in Smooth Muscle Cells Ameliorates Hypermuscularization and Stenosis in Elastin Aortopathy. Circulation. 2023. 148. Suppl_1. A11680
Fatima Z. Saddouk, Andrew kuzemczak, Junichi Saito, Daniel M. Greif. Endothelial And Smooth Muscle Cell Interaction In The Maintenance Of Pathological Muscularization In Pulmonary Hypertension. Arteriosclerosis, Thrombosis, and Vascular Biology. 2023. 43. Suppl_1. A658
伊藤智子, 横山詩子, 横山詩子, 中川路太一, 齋藤純一, 二町尚樹, 益田宗孝, 麻生俊英, 石川義弘. 内皮細胞が誘導する一方向性平滑筋細胞遊走が動脈管内膜肥厚を形成する. 日本小児循環器学会雑誌. 2019. 35. Supplement 1. s1.167-167
釼持孝博, 釼持孝博, 横山詩子, 齋藤純一, 伊藤智子, 魚住梓, 岩崎志穂, 西巻滋, 関和男, 石川義弘. ラット母体への分娩前ベタメタゾン投与が動脈管内膜肥厚へ与える作用の検討. 日本新生児成育医学会雑誌. 2018. 30. 3. 608-608

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Books (6)：

Expert Opinion on Pediatric Pharmacotherapy
Tokyo Igakusha 2023
The Vasculome: From Many to One. Out to the tissues: the arterial side.
Elsevier 2022 ISBN:9780128225462
Diagnosis and Treatment Based on Pathophysiology of Pediatric Diseases
Tokyo Igakusha 2020
Molecular Disease and Pulmonary Hypertension
Springer 2020 ISBN:9789811511851
Guyton and Hall Textbook of Medical Physiology Thirteen edition
ELSEVIER JAPAN 2018 ISBN:9784860347741

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Lectures and oral presentations (29)：

Sphingosine kinase 1 promotes arterial hypermuscularization with elastin deficiency
(American Physiology Summit 2025 2025)
Sphingosine Kinase 1 Is Integral For Elastin Deficiency-induced Arterial Hypermuscularization
(American Heart Association Scientific Sessions 2024 2024)
Sphingosine kinase 1 plays a key role in defective elastin-induced arterial hypermuscularization
(Vascular Biology 2024 2024)
スフィンゴシンキナーゼ1に焦点を当てた弾性線維異常による血管平滑筋細胞増殖の解明
(第101回日本生理学会大会 2024)
Presenilin 1 Deletion in Smooth Muscle Cells Ameliorates Hypermuscularization and Stenosis in Elastin Aortopathy.
(American Heart Association Scientific Sessions 2023 2023)

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Professional career (1)：

MD, PhD

Work history (1)：

2019/04 - 現在 Yale Cardiovascular Research Center, Yale University Depts of Cardiovascular Medicine Postdoctoral Fellow/Associate

Awards (19)：

2025/04 - American Physiological Society Finalist, Cardiovascular Section Outstanding Postdoctoral Trainee Award
2025/04 - Japan Pediatric Society Japan Pediatric Society Scientific Research Award
2024/11 - American Heart Association Finalist, Elaine W. Raines Early Career Investigator Award
2024/09 - Japan Medical Association Medical Research Encouragement Prize of The Japan Medical Association
2024/04 - NIH/NHLBI NIH Pathway to Independence Award (K99/R00)

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Association Membership(s) (11)：

Japan Medical Association , North American Vascular Biology Organization , Janeway Society, Yale University School of Medicine , American Physical Society , The Physiological Society of Japan , American Heart Association , The Japanese Circulation Society , Japanese Society of Pediatric Cardiology and Cardiac Surgery , Japan Society for Neonatal Health and Development , Japan Society of Perinatal and Neonatal Medicine , Japan Pediatric Society

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