2020 - 2023 A novel model of multiple sclerosis and multiple system atrophy that are differentially manifested by the time of abnormal protein expression
2019 - 2022 Significance of and treatment against galectin-3 and p22 accompanied with glial inflamation in ALS spinal cord
2019 - 2022 Development of treatment for multiple sclerosis based on rice consumption, a newly identified environmental risk factor
2019 - 2022 Establishment of primary-progressive multiple sclerosis (PPMS)/multiple system atrophy (MSA) mice model
2019 - 2022 Misfold protein removal therapy with CCR2-positive cells from peripheral nerves in motor neuron disease
2019 - 2022 Elucidation of autoimmune mechanisms and developement of novel therapy for demyelinating diseases based on genetic and envrionmental risk factors and disease-specific anti-neural antibodies
2018 - 2021 A novel mice model of MSA by overexpression of mutant alpha-synuclein in oligodendroglia in a temporarily restrictive manner using Tet-off system
2017 - 2020 Development of new MR neurography with simultaneous T2 mapping
2017 - 2020 Elucidation of the role of glial cell in tau transmission and axonal degeneration in Alzheimer's disease and targeted therapy with glial cell
2017 - 2019 Establishment of world-premier pachymeningitis animal model and development of new therapeutic option targeting TGF-beta.
2016 - 2019 The origin of retrograde motor neuron degeneration elicited by activated microglia in pre- or early-symptomatic spinal cord tissues from human patients with amyotrophic lateral sclerosis
2016 - 2019 Development of new therapeutic options for multiple sclerosis by suppression of CNS immune system augmentation due to the malfunction of astroglia connexin
2016 - 2019 Elucidation of mechanisms for destruction and fixation of glia-syncytium in demyelinating diseases by whole-genome sequencing and immunohistochemical analysis.
2015 - 2018 Retro-element insertion polymorphism in pathogenic Th17 cells specific for multiple sclerosis and its action
2015 - 2018 Elucidation of pathomecanisms via CCR2 positive monocyte-dependent neuroprotection in the amyotrophic lateral sclerosis model mice.
2015 - 2018 Therapy for multiple sclerosis targeting gamma-delta T cells and innate immunity based on genome-wide association studies in Japanese population
2013 - 2018 Elucidasion of functional contribution of glial dysturbances in pathomechanisms of demyelinating diseases and schizophrenia and development of new therapeutic options
2014 - 2017 Extensive disruption of energy transports via glial syncytium in demyelinating diseases
2014 - 2017 Development of apomorphine therapy targeting insulin resistance in Alzheimer's disease
2013 - 2016 Complete remission induction therapy development of multiple sclerosis by selective - timed activation of the protective microglia
2013 - 2016 connexin cytopathy in the pathogenesis of demyelinating disorders
Kaoru Yagita, Hiroyuki Honda, Tomoyuki Ohara, Sachiko Koyama, Hideko Noguchi, Yoshinao Oda, Ryo Yamasaki, Noriko Isobe, Toshiharu Ninomiya. Association between hypothalamic Alzheimer's disease pathology and body mass index: The Hisayama study. Neuropathology : official journal of the Japanese Society of Neuropathology. 2024
Senri Ko, Ryo Yamasaki, Tasuku Okui, Wataru Shiraishi, Mitsuru Watanabe, Yu Hashimoto, Yuko Kobayakawa, Susumu Kusunoki, Jun-ichi Kira, Noriko Isobe. A nationwide survey of facial onset sensory and motor neuronopathy in Japan. Journal of the Neurological Sciences. 2024. 122957-122957
Hitoshi Hayashida, Katsuhisa Masaki, Hidenori Ogata, Takahiro Yamaguchi, Koji Tanaka, Koichi Arimura, Yasuhiro Maruoka, Kazufumi Kikuchi, Osamu Togao, Ryo Yamasaki, et al. Focal 18F-fluorodeoxyglucose uptake in spinal dural arteriovenous fistula: A report of two cases. Neurology and Clinical Neuroscience. 2024
