Rchr
J-GLOBAL ID：201601011547240699
Update date: May. 22, 2024
Yoshizawa Tatsuya
ヨシザワ タツヤ | Yoshizawa Tatsuya
Affiliation and department：
Job title：
Professor
Research field (4)：
Nutrition and health science
, Physiology
, Pathobiochemistry
, Metabolism and endocrinology
Research theme for competitive and other funds (26)：
- 2023 - 2026 破骨細胞をターゲットにした超分子による骨吸収抑制治療薬の新たなアプローチ
- 2023 - 2026 運動器を基軸とした翻訳後脂質修飾タンパク質による恒常性維持機構の解明
- 2022 - 2025 Regulation of glucose metabolism by SIRT7
- 2022 - 2024 グルココルチコイド作用を分ける新規転写制御機構の解明および副作用軽減法の開発
- 2020 - 2023 骨結合性超分子による破骨細胞機能調節 -骨吸収抑制新規治療薬の開発-
- 2020 - 2023 中鎖脂肪酸修飾タンパク質による新たな運動器恒常性維持機構の解明
- 2020 - 2022 New roles of bone tissue in the maintenance of homeostasis.
- 2019 - 2022 Identification of the metabolic roles of SIRT7 and the development of its regulation.
- 2019 - 2021 Molecular mechanism of metabolic regulation through protein acylations
- 2017 - 2021 Study of the mechanism of sphingolipids on bone metabolism
- 2018 - 2020 中長鎖脂肪酸アシル化修飾タンパク質による運動器を基軸とした代謝調節機構の解明
- 2017 - 2019 タンパク質リジンアシル化修飾の調節による幹細胞システムの制御とその加齢変化
- 2017 - 2019 Elucidation of egulatory mechanism of bone metabolism by lysine deacylase SIRT7.
- 2016 - 2019 Identification of the multifaceted metabolic roles of SIRT7
- 2014 - 2017 Sphingomyelin regulates blood glucose levels by bone tissue
- 2014 - 2017 The new function of insulin in gut.
- 2013 - 2016 Molecular mechanism of diabetes mellitus based on beta-cell transcription factor network
- 2011 - 2013 Study of the new insulin action in the peripheral tissues
- 2011 - 2013 The availability of elderly-friendly macromolecule polysaccharide in periodontal tissue.
- 2005 - 2007 石灰化促進・抑制機構を骨芽細胞と靭帯線維芽細胞を用いて探る
- 2004 - 2006 Cell-specific response to mechanical stress and regulatory mechanism of differentiation : ligament/tendon cells versus osteoblasts
- 2003 - 2004 歯根膜細胞の特性と分化制御機構の解析
- 2002 - 2003 Molecular mechanism of osteogenesis-induced osteogenesis
- 2000 - 2001 歯根膜細胞から硬組織形成系細胞への分化制御機構の解析
- 2000 - 2001 On the analysis and regulatory mechanism of genes responsible for mechanical stress-induced osteoblast differentiation and osteogenesis
- 1998 - 1999 Mechanism of mechanical stress-induced osteoblast differentiation and osteogenesis
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Papers (67)：
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Kazuya Yamagata, Tomoya Mizumoto, Tatsuya Yoshizawa. The Emerging Role of SIRT7 in Glucose and Lipid Metabolism. Cells. 2023. 13. 1. 48-48
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Tomonori Tsuyama, Yoshifumi Sato, Tatsuya Yoshizawa, Takaaki Matsuoka, Kazuya Yamagata. Hypoxia causes pancreatic β-cell dysfunction and impairs insulin secretion by activating the transcriptional repressor BHLHE40. EMBO reports. 2023. 24. e56227
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Tatsuya Yoshizawa, Yoshifumi Sato, Shihab U. Sobuz, Tomoya Mizumoto, Tomonori Tsuyama, Md. Fazlul Karim, Keishi Miyata, Masayoshi Tasaki, Masaya Yamazaki, Yuichi Kariba, et al. SIRT7 suppresses energy expenditure and thermogenesis by regulating brown adipose tissue functions in mice. Nature Communications. 2022. 13. 1. 7439
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Tomoya Mizumoto, Tatsuya Yoshizawa, Yoshifumi Sato, Takaaki Ito, Tomonori Tsuyama, Akiko Satoh, Satoshi Araki, Kenichi Tsujita, Masaru Tamura, Yuichi Oike, et al. SIRT7 Deficiency Protects against Aging-Associated Glucose Intolerance and Extends Lifespan in Male Mice. Cells. 2022. 11. 22
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Masaji Sakaguchi, Shota Okagawa, Yuma Okubo, Yuri Otsuka, Kazuki Fukuda, Motoyuki Igata, Tatsuya Kondo, Yoshifumi Sato, Tatsuya Yoshizawa, Takaichi Fukuda, et al. Phosphatase protector alpha4 (α4) is involved in adipocyte maintenance and mitochondrial homeostasis through regulation of insulin signaling. Nature Communications. 2022. 13. 1. 6092-6092
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MISC (67)：
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吉澤達也. 骨とエネルギー代謝. 糖尿病・内分泌代謝科. 2022. 54. 3. 249-258
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吉澤 達也. Protein lysine acylations and disease control. 医学のあゆみ. 2019. 269. 13. 1201-1207
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吉澤 達也. 骨芽細胞とエピジェネティクス. BIO Clinica. 2019. 34. 8. 22-27
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吉澤 達也. 糖尿病治療薬と骨粗鬆症、インスリン. 糖尿病と骨粗鬆症-治療薬を考える- 井上大輔 編. 2018
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佐藤 叔史, 津山 友徳, 吉澤 達也, 井上 正宏, 山縣 和也. 膵β細胞における低酸素誘導因子BHLHE40の機能解析. 生命科学系学会合同年次大会. 2017. 2017年度. [2P-1034]
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Lectures and oral presentations (24)：
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The diverse functions of NAD-dependent lysine deacylase SIRT7
(Korean Society for Biochemistry and Molecular Biology (KSBMB) International Conference 2021 2021)
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脱アシル化酵素SIRT7 による骨格筋の制御
(第8回 骨格筋生物学研究会 2021)
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Role of NAD-dependent lysine deacylase in bone
(The 16th Bone Biology Forum 2019)
-
SIRT7によるエネルギー代謝調節
(日本筋学会第4回学術集会 2018)
-
脱アシル化酵素SIRT7によるエネルギー代謝制御
(第72回日本栄養・食糧学会大会 2018)
ｍore...
Education (2)：
- - 1999 The University of Tokyo
- - 1993 Tokyo University of Agriculture Faculty of Agriculture
Professional career (1)：
Work history (6)：
Awards (6)：
- 2016 - 熊本医学会奨励賞
- 2015 - 日本糖尿病学会九州支部賞
- 2007 - 歯科基礎医学会賞
- 2002 - 日本骨代謝学会 優秀演題賞
- 1996 - Keystone Symposium (Nuclear Receptor Superfamily) Travel Award
- 1996 - 日本骨代謝学会 優秀演題賞
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