Rchr
J-GLOBAL ID：201601013970746240   Update date: Oct. 28, 2024

Tomohito Higashi

ヒガシ トモヒト | Tomohito Higashi
Affiliation and department：
Fukushima Medical University School of Medicine

About Fukushima Medical University School of Medicine


Research field  (2)： Cell biology ,  Experimental pathology
Research keywords  (13)： クローディン ,  プロテアーゼ ,  EpCAM ,  動的制御 ,  TAMP family proteins ,  Angulins ,  Vinculin ,  Formins ,  Actin cytoskeleton ,  Cytokinesis ,  Tricellular junctions ,  Cell-cell adhesion ,  Tight junctions
Research theme for competitive and other funds  (10)：
  • 2024 - 2027 トリセルラーAJをかたちづくる分子の解明
  • 2021 - 2024 Molecular mechanism of tight junction maintenance by proteases
  • 2018 - 2021 Fate decision of intestinal stem cells by tight junction molecules
  • 2018 - 2021 Mechanisms of actin assembly athte ontractile rings and cell-cell junctions
  • 2011 - 2013 細胞間接着形成時のアクチン細胞骨格再構成を制御する分子機構の解析
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Papers (44)：
  • Atsuko Y Higashi, Akira C Saito, Tomohito Higashi, Kyoko Furuse, Mikio Furuse, Hideki Chiba, Junichiro J Kazama. Bicellular Localization of Tricellular Junctional Protein Angulin-3/ILDR2 Allows Detection of Podocyte Injury. American Journal of Pathology. 2024. 194. 5. 673-683
  • Tomohito Higashi, Akira C Saito, Hideki Chiba. Damage control of epithelial barrier function in dynamic environments. European Journal of Cell Biology. 2024. 103. 2. 151410-151410
  • Tomohito Higashi, Rachel E Stephenson, Cornelia Schwayer, Karla Huljev, Atsuko Y Higashi, Carl-Philipp Heisenberg, Hideki Chiba, Ann L Miller. ZnUMBA - a live imaging method to detect local barrier breaches. Journal of Cell Science. 2023. 136. 15
  • Akira C Saito, Tomohito Higashi, Hideki Chiba. Tight-junction strand networks and tightness of the epithelial barrier. Microscopy (Oxford, England). 2023. 72. 3. 213-225
  • Tomohito Higashi, Akira C Saito, Yugo Fukazawa, Mikio Furuse, Atsuko Y Higashi, Masahiro Ono, Hideki Chiba. EpCAM proteolysis and release of complexed claudin-7 repair and maintain the tight junction barrier. Journal of Cell Biology. 2023. 222. 1
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MISC (17)：
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Books (1)：
  • Tight Junctions
    2022 ISBN:3030972038
Lectures and oral presentations  (11)：
  • Proteinase-mediated tight junction damage surveillance and repair.
    (Shenyang Brain Science and Disease Symposium 2023)
  • EpCAMの限定分解による密着結合の修復機構
    (生理学研究所上皮研究会 2023)
  • Proteinase-mediated tight junction damage surveillance and repair
    (Gordon Research Conference (GRC) on Cell Contact and Adhesion 2023)
  • Proteinase-mediated tight junction damage surveillance and repair
    (2022)
  • Occludin and tricellulin regulate the complexity of TJ strand network and epithelial barrier function
    (4th International Tight Junction Conference 2021)
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Education (3)：
  • 2005 - 2008 Kyoto University Graduate School of Medicine Medical Science
  • 2003 - 2005 Kyoto University Graduate School of Medicine Medical Science
  • 1999 - 2003 Kyoto University Faculty of Science Biology
Professional career (3)：
  • 博士(医科学) (京都大学)
  • 修士(医科学) (京都大学)
  • 学士(理学) (京都大学)
Work history (8)：
  • 2020/03 - 現在 Fukushima Medical University Department of Basic Pathology Associate Professor
  • 2018/03 - 2020/02 Fukushima Medical University Department of Basic Pathology Assistant Professor
  • 2017/08 - 2018/02 Fukushima Medical University Department of Basic Pathology Assistant Professor
  • 2016/04 - 2017/07 University of Michigan Molecular, Cellular, and Developmental Biology Postdoctoral research fellow
  • 2014/04 - 2016/03 University of Michigan Molecular, Cellular, and Developmental Biology JSPS Postdoctoral Research Fellow
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Committee career (2)：
  • 2024/08 - 現在 福島県立医科大学 一般倫理委員会 副委員長
  • 2022/08 - 現在 福島県立医科大学 一般倫理委員会 委員
Association Membership(s) (3)：
日本分子生物学会 ,  日本細胞生物学会 ,  American society for cell biology
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