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J-GLOBAL ID：201601014824797050 Update date: Apr. 01, 2025

Takayama Kazuo

タカヤマカズオ | Takayama Kazuo

Affiliation and department：
Job title： Professor

Research field (1)： Clinical pharmacy

Research keywords (7)：ウイルス , オルガノイド , 感染症 , organs-on-a-chip , iPS cells , pluripotent stem cells , drug discovery

Research theme for competitive and other funds (5)：

2021 - 2024 Elucidation of the role of basal stem cells in respiratory diseases
2018 - 2020 Elucidation of mechanism of chronic intestinal inflammation at single-cell level using optogenetic technique
2017 - 2019 Generation of zone-specific hepatocyte for study of liver injury and diseases
2016 - 2019 光照射により任意の組織においてゲノム編集・遺伝子発現操作する技術の開発
2015 - 2017 Generation of CYP3A4-expressing human ES/iPS cell-derived hepatocytes for drug screening

Papers (137)：

Shuhei Tsujino, Masumi Tsuda, Naganori Nao, Kaho Okumura, Lei Wang, Yoshitaka Oda, Yume Mimura, Jingshu Li, Rina Hashimoto, Yasufumi Matsumura, et al. Evolution of BA.2.86 to JN.1 reveals functional changes in non-structural viral proteins are required for fitness of SARS-CoV-2. 2025
Masatoshi Kakizaki, Rina Hashimoto, Noriyo Nagata, Takuya Yamamoto, Takashi Okura, Hiroshi Katoh, Yuki Kitai, Yukiko Akahori, Kazuya Shirato, Akihide Ryo, et al. The respective roles of TMPRSS2 and cathepsins for SARS-CoV-2 infection in human respiratory organoids. Journal of virology. 2024. e0185324
Sayaka Deguchi, Fuki Yokoi, Kazuo Takayama. Organoids and microphysiological systems for pharmaceutical research of viral respiratory infections. Drug metabolism and pharmacokinetics. 2024. 60. 101041-101041
Junya Michibata, Yoshimasa Kawaguchi, Hisaaki Hirose, Akiko Eguchi, Sayaka Deguchi, Kazuo Takayama, Wei Xu, Takuro Niidome, Yoshihiro Sasaki, Kazunari Akiyoshi, et al. Polysaccharide-Based Coacervate Microgel Bearing Cationic Peptides That Achieve Dynamic Cell-Membrane Structure Alteration and Facile Cytosolic Infusion of IgGs. Bioconjugate chemistry. 2024
Masako Yamasaki, Wakana Saso, Takuya Yamamoto, Masayoshi Sato, Hiroko Takagi, Tetsuya Hasegawa, Yuji Kozakura, Hiroyuki Yokoi, Hirofumi Ohashi, Kana Tsuchimoto, et al. Anti-SARS-CoV-2 gapmer antisense oligonucleotides targeting the main protease region of viral RNA. Antiviral research. 2024. 230. 105992-105992

Education (2)：

Professional career (1)：

Work history (6)：

2025/02 - 現在 Institute of Science Tokyo Department of Synthetic Human Body System, Medical Research Institute Professor
2020/03 - 現在京都大学iPS細胞研究所講師
2016/10 - 2020/03 さきがけ研究者
2018/02 - 2020/02 Osaka University Graduate School of Pharmaceutical Sciences
2015/04 - 2018/01 Osaka University Graduate School of Pharmaceutical Sciences, Drug Innovation Center

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Association Membership(s) (2)：

日本動物実験代替法学会 , 日本ウイルス学会

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