Kikuchi Hidetomo

キクチヒデトモ | Kikuchi Hidetomo

Affiliation and department：
Job title： Assistant Professor
Homepage URL (1)： https://scholar.google.com/citations?user=DCZYwe8AAAAJ&hl=en

Research field (7)： Tumor biology , Tumor diagnostics and therapeutics , Pharmacology , Pharmaceuticals - health and biochemistry , Nutrition and health science , Biological, health, and medical informatics , Science education

Research keywords (9)： Cancer , Lifestyle disease , Dihydropyrimidine , Natural products , Flavonoid , Cell homeostasis , Computer Science , Functional foods , Food-Drug interaction

Research theme for competitive and other funds (9)：

2024 - 2027 Fundamental research of antitumor activity of darinaparsin, a novel organic arsenical, against leukemic cells
2024 - 2027 RXRを分子標的としたジヒドロピリミジン誘導体の抗悪性腫瘍薬への基礎的研究
2020 - 2024 新規抗悪性腫瘍薬darinaparsinの抗がん作用メカニズムに関する研究
2020 - 2023 Fundamental research of antitumor activity of arsenic compound in combination with active bufadienolide compounds against glioblastoma cells
2018 - 2020 食品と医薬品の相互作用情報にもとづいたメニュー開発と健康情報の発信に関する研究

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Papers (23)：

Bo Yuan, Hidetomo Kikuchi, Jingmei Li, Atsushi Kawabata, Kozo Yao, Norio Takagi, Mari Okazaki. Cytotoxic Effects of Darinaparsin, a Novel Organic Arsenical, against Human Leukemia Cells. International Journal of Molecular Sciences. 2023. 24. 3. 2282-2282
Bo Yuan, Jingmei Li, Shin-Ichi Miyashita, Hidetomo Kikuchi, Meiyan Xuan, Hirokazu Matsuzaki, Naohiro Iwata, Shinya Kamiuchi, Katsuyoshi Sunaga, Yasuhide Hibino, et al. Enhanced cytotoxic effects of arenite in combination with active bufadienolide compounds against human glioblastoma cell line U-87. Molecules. 2022. 27. 19. 6577-6577
Yoshio Nishimura, Hidetomo Kikuchi, Takanori Kubo, Rie Arai, Yuki Toguchi, Bo Yuan, Katsuyoshi Sunaga, Hidetsura Cho. Synthesis of 4,4-Disubstituted 3,4-Dihydropyrimidin-2(1H)-ones and -thiones, the Corresponding Products of Biginelli Reaction Using Ketone, and Their Antiproliferative Effect on HL-60 Cells. Chemical and Pharmaceutical Bulletin. 2022. 70. 2. 111-119
Yoshio Nishimura, Hidetomo Kikuchi, Takanori Kubo, Ibuki Nakakita, Mari Oguni, Misaki Ohta, Rie Arai, Bo Yuan, Katsuyoshi Sunaga, Hidetsura Cho. Erratum to “Synthesis of novel 6-unsubstituted 2-aminodihydropyrimidines by Sc(OTf)3-mediated amination and their antiproliferative effect on HL-60 cells” [Tetrahedron Lett. 65 (2021) 152760] (Tetrahedron Letters (2021) 65, (S0040403920312752), (10.1016/j.tetlet.2020.152760)). Tetrahedron Letters. 2021. 76
Tadasuke Nozaki, Masayuki Takahashi, Tatsuya Ishikawa, Arisa Haino, Mineaki Seki, Hidetomo Kikuchi, Bo Yuan, Masayuki Nashimoto. The heptamer sgRNA targeting the human OCT4 mRNA can upregulate the OCT4 expression. Biochemistry and Biophysics Reports. 2021. 26. 100918-100918

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MISC (18)：

Katsuyoshi Sunaga, Hidetomo Kikuchi. Drug-Food interaction. The Japanese Journal of Clinical Nutrition. 2023. 142. 7. 1073-1080
Katsuyoshi Sunaga, Hidetomo Kikuchi. Interactions between foods and drugs. New Food Industry. 2022. 64. 11. 709-723
渡口由姫, 菊地秀与, 西村良夫, 袁博, 新井理絵, 久保貴紀, 長秀連, 須永克佳. ヒト急性前骨髄球性白血病細胞株NB4に対する2-methylthio dihydropyrimidine誘導体の細胞毒性. 日本薬学会年会要旨集. 2022. 142年会. 26PO5-06S
Hidetomo Kikuchi, Rie Arai, Shiori Yoshida, Naohiro Iwata. Statistical Analysis of Text on National Examination for Registered Dietitian - An example study at the area of “nutrition of carbohydrates” in basic nutrition -. Josai Information Sciences Researches. 2022. 29. 1. 38-49
KIKUCHI, Hidetomo, IWATA, Naohiro, ARAI, Rie. An example of giving an online lecture utilizing the “Microsoft Teams” -A case of “Pharmacotherapy A”, a specialized subject in the course of Clinical Nutrition, Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmacy and Pharmaceutical Sciences-. JOSAI INFORMATION SCIENCES RESEARCHES. 2021. 28. 1. 8-15

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Patents (4)：

BRAIN FUNCTION REGULATING AGENT, AND FOOD OR BEVERAGE PRODUCT CONTAINING SAME
BRAIN FUNCTION REGULATING AGENT, AND FOOD OR BEVERAGE PRODUCT CONTAINING SAME
BRAIN FUNCTION REGULATOR, AND FOOD OR BEVERAGE CONTAINING SAME
BRAIN FUNCTION REGULATING AGENT, AND FOOD OR BEVERAGE PRODUCT CONTAINING SAME

Books (3)：

患者さん目線から考えるがんの栄養・食事ガイドブック
メディカルレビュー社 2017
管理栄養士過去問ここだけ丸暗記
技術評論社 2016
管理栄養士国家試験対策問題集
技術評論社 2015

Lectures and oral presentations (49)：

Differentiation inducing effect of ATRA in combination with 2-methylthio dihydropyrimidine on human leukemia NB4 cells
(The 143rd Annual Meeting of the Pharmaceutical Society of Japan (Sapporo) 2023)
Involvement of Caspases and MAP kinase in 2-methylthio dihydropyrimidine-triggered cytotoxicity against human leukemia NB4 cells
(The 143rd Annual Meeting of the Pharmaceutical Society of Japan (Sapporo) 2023)
Enhanced cytotoxicity of arenite combinated with bufadienolides against human glioblastoma cell line U-87
(The 143rd Annual Meeting of the Pharmaceutical Society of Japan (Sapporo) 2023)
ヒトOCT4 mRNAを標的とするheptamer型sgRNAはOCT4の発現を上昇させることができる
(第26回日本バイオ治療法学会学術集会 2022)
ICTを活用したがん患者向けメニュー開発参加が管理栄養士養成施設学生の社会人基礎力及び専門力に与える影響
(第69回日本栄養改善学会学術総会 2022)

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Works (1)：

食用ハーブと薬の相互作用
菊地秀与 2023 - 2023

Education (3)：

2007 - 2010 Tokyo University of Pharmacy and Life Sciences Graduate School of Pharmacy Doctor's program
2005 - 2007 Tokyo University of Pharmacy and Life Sciences Graduate School of Pharmacy Master's program
2000 - 2004 Tokyo University of Pharmacy and Life Sciences School of Pharmacy

Professional career (1)：

Doctor of Pharmacy (Tokyo University of Pharmacy and Life Sciences)

Work history (3)：

2020/04 - 現在 Josai University Faculty of Pharmaceutical Sciences Department of Clinical Dietetics and Human Nutrition Associate professor
2014/04 - 2020/03 Josai University Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmacy and Pharmaceutical Sciences Assistant professor
2011/04 - 2014/03 Yasuda Women's University Faculty of Pharmacy, Department of Pharmacy Research associate

Association Membership(s) (4)：

Japan Society for Science Education , The Japanese Biochemical Society , Japan Society of Histochemistry and Cytochemistry , The Pharmaceutical Society of Japan

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