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J-GLOBAL ID：201601018442247820 Update date: Mar. 21, 2025

Miyazaki Teruo

ミヤザキテルオ | Miyazaki Teruo

Affiliation and department：
Job title：准教授

Research field (5)： Metabolism and endocrinology , Gastroenterology , Healthcare management, medical sociology , Physiology , Sports science

Research keywords (9)：胆汁酸 , 疲労 , 分岐鎖アミノ酸 , エネルギー代謝 , タウリン , 肝臓 , 骨格筋 , 運動 , アミノ酸

Research theme for competitive and other funds (32)：

2024 - 2027 腸内細菌を介したタウリンの健康増進効果の解明
2023 - 2027 Mechanism of sarcopenia development mediated by skeletal muscle bile acid receptors using a mouse model with human-like bile acid composition
2022 - 2025 胆汁酸ヒト化マウスを用いたNAFL/NASH/HCC進展メカニズムの解明
2022 - 2025 膵切除術後非アルコール性脂肪性肝疾患の病態解明と血清バイオマーカーの開発
2022 - 2025 低用量アスピリンによる小腸粘膜障害発症メカニズムの解明とリスク予測法の開発

2022 - 2025 胆汁酸ヒト化マウスを用いたNAFL/NASH/HCC進展メカニズムの解明

2022 - 2025 分岐鎖アミノ酸代謝物マイオカインの血糖上昇作用機序の解明

2021 - 2025 The influence of 27-hydroxycholesterol on the deterioration of pathology in the lung cancer complicated with interstitial pneumonia

2021 - 2024 糞便ステロイドミクス解析による腸管ディスバイオーシスの新しい評価方法の開発

2020 - 2023 肝硬変患者における骨格筋代償能の血液生化学的評価法の開発

2019 - 2022 Development of evaluation method for the three major nutrient utilization state during exercise using saliva sample

2018 - 2022 マイオカインとしてのタウリンの代謝調節作用の解明

2018 - 2021 Effects of biliary oxysterols on the growth of bile duct cancer

2018 - 2021 The promotion effect of 27-hydroxycholesterol as selective estrogen receptor modulator on the proliferation of lung cancer

2018 - 2021 Serum bile acid analysis of patients with Clostridium difficile -associated diarrhea

2018 - 2021 Comparative effect of ursodeoxycholic acid and more hydrophilic bile acids on hepatoprotection

2017 - 2020 Production and phenotype analysis of mouse models with humanized bile acid composition

2016 - 2020 Association of oxysterol imbalance in disease progression of non alcoholic steathepatitis

2016 - 2019 Involvement of amino acid metabolite in skeletal muscle on the onset of exercise-induced central fatigue

2015 - 2018 Serum metabolomics analysis of patients with fatty liver due to undernutrition

2015 - 2018 The actions of BCAA intermediates as myokines on hepatic metabolism

2015 - 2018 Retention of acetylcarnitine in chronic kidney disease causes insulin resistance in skeletal muscle

2015 - 2018 Identification of bile acid 6beta-hydroxylase in mouse liver

2014 - 2017 Application of serum bile acid profile as a new marker for gut microbiota

2013 - 2016 Serum lipid biomarker for the prediction of non-B, non-C liver cancer development

2013 - 2016 Usefulness of noninvasive monitoring method for tissue-specific energy metabolism in human

2012 - 2015 Development of new biomarkers for small intestinal malabsorption

2011 - 2015 Invasive metabolic markers for evaluation of host factor on the pathological progress of hepatitis C patients

2011 - 2013 Metabolite profiling of biological steroids in pathological tissue specimen

2011 - 2013 The effect of taurine supplementation on maintenance of blood glucose level during prolonged exercise

2010 - 2012 Non-invasive measurement of serum lipid metabolism biomarkers in patients with HCV infection

2009 - 2011 Development of novel alternative approach for liver cirrhosis therapy using adipose-derived stem cells

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Papers (81)：

Hajime Ueda, Akira Honda, Teruo Miyazaki, Yukio Morishita, Takeshi Hirayama, Junichi Iwamoto, Tadashi Ikegami. High-fat/high-sucrose diet results in a high rate of MASH with HCC in a mouse model of human-like bile acid composition. Hepatology Communications. 2025. 9. 1. e0606
Masahiro Umemura, Akira Honda, Maho Yamashita, Takeshi Chida, Hidenao Noritake, Kenta Yamamoto, Takashi Honda, Mayuko Ichimura-Shimizu, Koichi Tsuneyama, Teruo Miyazaki, et al. High-fat diet modulates bile acid composition and gut microbiota, affecting severe cholangitis and cirrhotic change in murine primary biliary cholangitis. Journal of autoimmunity. 2024. 148. 103287-103287
Teruo Miyazaki. Identification of a novel enzyme and the regulation of key enzymes in mammalian taurine synthesis. Journal of Pharmacological Sciences. 2024. 154. 1. 9-17
Teruo Miyazaki, Hajime Ueda, Tadashi Ikegami, Akira Honda. Upregulation of Taurine Biosynthesis and Bile Acid Conjugation with Taurine through FXR in a Mouse Model with Human-like Bile Acid Composition. Metabolites. 2023. 13. 7. 824
Maho Yamashita, Akira Honda, Shin Shimoyama, Masahiro Umemura, Kazuyoshi Ohta, Takeshi Chida, Hidenao Noritake, Nobuhito Kurono, Mayuko Ichimura-Shimizu, Koichi Tsuneyama, et al. Breach of tolerance versus burden of bile acids: Resolving the conundrum in the immunopathogenesis and natural history of primary biliary cholangitis. Journal of autoimmunity. 2023. 136. 103027-103027

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MISC (257)：

Akiko Eguchi, Motoh Iwasa, Motoyuki Kohjima, Teruo Miyazaki, Naoki Yamashita, Mina Tempaku, Kiyora Izuoka, Yoshinao Kobayashi, Yoshiyuki Takei, Akira Honda, et al. Elevation of Conjugated Bile Acids and IL-6 in Chronic Liver Diseases Regulates Muscle Types and Inflammation. Hepatology. 2024. 80. S1. S1619-S1620
Hajime Ueda, Akira Honda, Teruo Miyazaki, Tadashi Ikegami. Hepatic chenodeoxycholic acid promotes MASH with HCC in high-fat/high-sucrose diet-fed mice with human-like bile acid composition. Hepatology. 2024. 80. S1. S10-S11
Teruo Miyazaki, Hajime Ueda, Tadashi Ikegami, Akira Honda. Hydrophobic secondary bile acids induce primary sclerosing cholangitis through the liver-large intestine axis in a Cyp2c70-/-/Cyp2a12-/- mouse with human-type bile acid composition. Hepatology. 2024. 80. S1. S1567-S1568
宮﨑照雄, 上田元, 池上正, 本多彰. 胆汁酸によるタウリンの動態制御の雌雄差;胆汁酸ヒト化マウスを用いた検討. タウリンリサーチ. 2024. 10. 1. 8-12
門馬匡邦, 岩本淳一, 玉虫惇, 上田元, 小西直樹, 屋良昭一郎, 宮﨑照雄, 池上正, 本多彰. 血中胆汁酸分析を用いたdysbiosisの評価. 消化と吸収. 2024. 46. 2. 155-158

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Patents (1)：

唾液試料の調製方法

Books (4)：

Regulation and Effect of Taurine on Metabolism
MDPI 2023 ISBN:9783036568751
読んで効くタウリンのはなし
成山堂書店 2016
運動生理学20講第3版
朝倉書店 2015
科学大辞典第2判国際科学振興財団編
丸善出版社 2005

Lectures and oral presentations (133)：

原発性硬化性胆管炎モデルマウスに対するタウリン摂取の影響
(第11回国際タウリン研究会学術集会 2025)
疎水性胆汁酸による原発性硬化性胆管炎発症機序の検討
(第45回胆汁酸研究会 2024)
Hydrophobic secondary bile acids induce primary sclerosing cholangitis through the liver-large intestine axis in a Cyp2c70-/-/Cyp2a12-/- mouse with human-type bile acid composition
(AASLD The Liver Meeting 2024 2024)
骨格筋由来バリン中間代謝物3-ヒドロキシイソ酪酸による血糖値上昇作用
(第32回日本運動生理学会大会 2024)
The influence of hydrophobic bile acids on the onset of sclerosing cholangitis in a Cyp2c70/Cyp2a12 DKO mouse
(XXVII International Bile Acid Meeting (Falk Symposium 237) 2024)

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Professional career (1)：

博士(医学) (筑波大学)

Committee career (8)：

2021/08 - 現在 Metabolites Editorial Board
- 現在日本運動生理学会評議員
- 現在日本体力医学会評議員
- 現在国際タウリン研究会日本部会理事/発起人
2022/08 - 2023/05 Guest Editor, special issue of "Effect of Sulfur-Containing Amino Acids and Sulfur Compounds on Metabolism Volume 2" in MDPI

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Association Membership(s) (12)：

International Taurine Society , 国際タウリン研究会日本部会 , JAPAN SOCIETY OF EXERCISE AND SPORTS PHYSIOLOGY , The American Society for Biochemistry and Molecular Biology , American Association for Cancer Research , 胆汁酸研究会 , 日本抗加齢医学会 , JAPAN SOCIETY OF PHYSICAL EDUCATION, HEALTH AND SPORT SCIENCES , THE JAPANESE SOCIETY OF PHYSICAL FITNESS AND SPORTS MEDICINE , JAPANESE SOCIETY OF GASTROENTEROLOGY , THE JAPAN SOCIETY OF HEPATOLOGY , European College of Sport Science

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