Izuo Naotaka

イズオナオタカ | Izuo Naotaka

Affiliation and department：
Homepage URL (1)： https://kaken.nii.ac.jp/d/r/50722261.ja.html

Research field (5)： Neuroscience - general , Pharmacology , Internal medicine - General , Laboratory animal science , Neuroscience - general

Research keywords (24)： Exosome , 細胞間コミュニケーション , Aging , 中枢神経系 , モデル動物作成 , グリア細胞 , 精神疾患 , Neurodegeneration , アルツハイマー病 , うつ病 , 統合失調症 , Biomarker , 神経免疫学 , 頚部リンパ節 , リンパ球 , 薬物依存 , パーキンソン病 , Brain stroke , Reverse Translational Research , 生活習慣病 , 2型糖尿病 , インスリン抵抗性 , 神経科学 , 薬理学

Research theme for competitive and other funds (9)：

2023 - 2027 Structural chemistry of intracellular recognition by nucleic acid aptamers and brain barrier permeation strategies for the treatment of neurodegenerative disease
2023 - 2026 頚部リンパ節から脳内浸潤する末梢T細胞のドパミン神経伝達に対する制御機構
2022 - 2025 Transport mechanisms of cell-penetrating peptides at the blood-retinal barrier to establish strategies of macromolecular drug delivery
2022 - 2025 Impact of parvalbumin neuron dysfunction on behavioral and psychological symptom in Alzheimer's disease.
2021 - 2024 Production of a bipolar model mice and clarification of the neuronal mechanism of the manic switch

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Papers (40)：

Yuka Kusui, Naotaka Izuo, Reika Tokuhara, Takashi Asano, Atsumi Nitta. Neuronal activation of nucleus accumbens by local methamphetamine administration induces cognitive impairment through microglial inflammation in mice. Journal of pharmacological sciences. 2024. 154. 3. 127-138
Naotaka Izuo, Nobuhiro Watanabe, Yoshihiro Noda, Takashi Saito, Takaomi C Saido, Koutaro Yokote, Harumi Hotta, Takahiko Shimizu. Insulin resistance induces earlier initiation of cognitive dysfunction mediated by cholinergic deregulation in a mouse model of Alzheimer's disease. Aging cell. 2023. e13994
Hajime Miyanishi, Shiori Suga, Kazuyuki Sumi, Miho Takakuwa, Naotaka Izuo, Takashi Asano, Shin-Ichi Muramatsu, Atsumi Nitta. The Role of GABA in the Dorsal Striatum-Raphe Nucleus Circuit Regulating Stress Vulnerability in Male Mice with High Levels of Shati/Nat8l. eNeuro. 2023. 10. 10
Kota Taniwa, Kazuma Murakami, Yoshiki Sakaguchi, Naotaka Izuo, Mizuho Hanaki, Nobuaki Sampa, Toshiaki Kume, Takahiko Shimizu, Kazuhiro Irie. Detection of Dietary Chalcone and Flavonoid Metabolites in Mice Using UPLC-MS/MS and Their Modulatory Effects on Amyloid β Aggregation. Journal of Agricultural and Food Chemistry. 2023
Naotaka Izuo, Hajime Miyanishi, Daisuke Nishizawa, Takuma Fujii, Junko Hasegawa, Naomi Sato, Fumihiko Tanioka, Haruhiko Sugimura, Kazutaka Ikeda, Atsumi Nitta. DNA methylation status of SHATI/NAT8L promoter in the blood of cigarette smokers. Neuropsychopharmacology Reports. 2023

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MISC (13)：

Tomohiro Tokutake, Takashi Asano, Naotaka Izuo, Atsumi Nitta. CB1 receptors in the mice prefrontal cortex regulate spatial cognitive function. 33rd World Congress of The International College of Neuropsychopharmacology (CINP2022), Taipei, Taiwan. 2022
Yuka Kusui, Naotaka Izuo, Reika Tokuhara, Atsumi Nitta. The cognitive impairement and the activation of hippocampal microglia induced by the methamphetamine-mediated excessive dopamine in the nucleus accumbens of mice. 33rd World Congress of The International College of Neuropsychopharmacology (CINP2022), Taipei, Taiwan. 2022
Naotaka Izuo, Akira Takahashi, Yuri Hirayama, Yuri Matsuo, Atsumi Nitta. Removal of cervical lymph nodes suppresses motor dysfunction in mice with cerebral ischemic stroke. 33rd World Congress of The International College of Neuropsychopharmacology (CINP2022), Taipei, Taiwan. 2022
高村雄策, 泉尾直孝, 久米利明, 入江一浩, 小松生明. 次世代型ADモデルApp^{NL-P-F/NL-P-F} KIマウスにおける心理行動異常と脳内変動. 日本生理学雑誌(Web). 2022. 84. 1
Kakeru Chino, Naotaka Izuo, Tomoharu Kuboyama, Chihiro Tohda, Shinichi Muramatsu, Nitta Atsumi. Effects of Shati/Nat8l overexpression on recovery of cognitive dysfunction in a mouse model of Alzheimer's disease. 7th Congress of Asian College of Neuropsychopharmacology (AsCNP2021), Singapore. 2021

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Patents (1)：

アミロイドβの22位及び23位のターン構造を極めて特異的に認識する抗体

Education (3)：

2010 - 2013 Kyoto University Graduate School of Pharmaceutical Sciences
2008 - 2010 Kyoto University Graduate School of Pharmaceutical Sciences Division of Pharmacy and Biomedicinal Sciences
2004 - 2008 Kyoto University Faculty of Pharmaceutical Sciences

Work history (9)：

2024/02 - 現在 The University of Tokyo Research Center for Advanced Science and Technology
2021 - 2024/03 東京都医学総合研究所精神行動医学研究分野・依存性物質プロジェクト協力研究員
2019/10 - 2024/01 University of Toyama Graduate School of Medicine and Pharmaceutical Sciences for Research
2019/06 - 2020/01 La Trobe University, La Trobe Institute of Molecular Science, Honorary Research Fellow
2019/04 - 2020/01 The Uehara Memorial Foundation, Postdoctoral Fellow

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Committee career (3)：

2021 - 現在日本薬理学会学術評議員
2020 - 現在国際神経精神薬理学会 (CINP) Fellow
2017/03 - 現在日本薬学会薬理系薬学部会若手世話人

Awards (4)：

2023/11 - 日本薬学会北陸支部学術奨励賞
2017/06 - 日本老年医学会優秀発表賞
2015/06 - 日本基礎老化学会若手奨励賞
2012/09 - 日本薬学会薬理系薬学部会次世代を担う創薬・医療薬理シンポジウム 2012 優秀発表賞

Association Membership(s) (8)：

北米神経科学会 , JAPAN SOCIETY FOR BIOMEDICAL GERONTOLOGY , JAPAN SOCIETY FOR DEMENTIA RESEARCH , THE PHARMACEUTICAL SOCIETY OF JAPAN , THE JAPANESE PHARMACOLOGICAL SOCIETY , 国際エクソソーム学会 , 日本神経精神薬理学会 , 国際神経精神薬理学会

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