Tega Yuma

Affiliation and department：

Research field (1)： Clinical pharmacy

Research keywords (4)：血液脳関門 , 血液組織関門 , 薬物動態 , トランスポーター

Research theme for competitive and other funds (3)：

2023 - 2026 血液脳関門ABC排出輸送体制御による多形性膠芽腫への薬物送達戦略構築と有望性実証
2019 - 2022 Functional elucidation of human blood-brain barrier using iPS-derived brain microvascular entdothelial cells
2019 - 2021 Characterization of structural requirement for substrates recognition and identification of the molecular entity of proton/organic cation antiporter expressed at the human blood-brain barrier

Papers (26)：

Takeru Ito, Yoshiyuki Kubo, Yuma Tega, Shin-Ichi Akanuma, Ken-Ichi Hosoya. Blood-to-Testis Transport of Ribavirin Involves Carrier-Mediated Processes at the Blood-Testis Barrier. Journal of pharmaceutical sciences. 2024
Ryuta Jomura, Masaru Sawada, Yuma Tega, Shin-Ichi Akanuma, Masanori Tachikawa, Ken-Ichi Hosoya. Molecular Mechanism of SLC6A8 Dysfunction with c.1699T > C (p.S567P) Mutation in Cerebral Creatine Deficiency Syndromes. Biological & pharmaceutical bulletin. 2024. 47. 1. 187-191
Yuma Tega, Toshinari Takeuchi, Masatoshi Nagano, Reina Makino, Yoshiyuki Kubo, Shin-Ichi Akanuma, Ken-Ichi Hosoya. Characterization of LysoTracker Red uptake by in vitro model cells of the outer blood-retinal barrier: Implication of lysosomal trapping with cytoplasmic vacuolation and cytotoxicity. Drug metabolism and pharmacokinetics. 2023. 51. 100510-100510
Yuma Tega, Yoshiyuki Kubo, Hiroaki Miura, Kairi Ri, Ayaka Tomise, Shin-Ichi Akanuma, Ken-Ichi Hosoya. Carrier-Mediated Process of Putrescine Elimination at the Rat Blood-Retinal Barrier. International journal of molecular sciences. 2023. 24. 10
Yusuke Shinozaki, Yuma Tega, Shin-Ichi Akanuma, Ken-Ichi Hosoya. The Structural Characteristics of Compounds Interacting with the Amantadine-Sensitive Drug Transport System at the Inner Blood-Retinal Barrier. Pharmaceuticals (Basel, Switzerland). 2023. 16. 3

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MISC (18)：

黒澤俊樹, 手賀悠真, 佐孝大樹, 出堀泰之, 冨原裕美, 天野信之, 出口芳春. Construction of 3D BBB model using brain microvascular endothelial cells derived from human induced pluripotent stem cells. 日本薬剤学会年会講演要旨集(CD-ROM). 2021. 36th
手賀悠真, 田畑英嗣, 黒澤俊樹, 北村敦, 板垣文雄, 忍足鉄太, 出口芳春. Membrane permeability of diphenhydramine derivatives via H⁺/organic cation antiporter. 日本薬学会年会要旨集(CD-ROM). 2020. 140年会. 26P-pm151
黒澤俊樹, 手賀悠真, 山口朋子, 川端健二, 望月達貴, 井上勝央, 楠原洋之, 出口芳春. Analysis of 6-mercaptopurine transport mechanism across blood-brain barrier model derived from human iPS cells. 日本薬剤学会年会講演要旨集(CD-ROM). 2020. 35th
古西修希, 伊藤慎悟, 上村立記, 増田豪, 樋口慧, 黒澤俊樹, 手賀悠真, 出口芳春, 大槻純男. Effects of Loss of P-glycoprotein of blood-brain barrier homeostasis. 日本薬剤学会年会講演要旨集(CD-ROM). 2020. 35th
古西修希, 伊藤慎悟, 上村立記, 増田豪, 樋口慧, 黒澤俊樹, 手賀悠真, 出口芳春, 大槻純男. ヒト脳毛細血管内皮細胞におけるP-glycoprotein欠損がプロテオームに与える変動. 電気泳動. 2019. 63. Suppl. 230-230

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Lectures and oral presentations (27)：

New approach to drug delivery across the blood-brain barrier via H+/organic cation antiporter.
(2019)
新しい中枢疾患モダリティを創製するためのヒト血液脳関門機能の理解
(日本薬学会第139年会 2019)
ヒト血液脳関門におけるH+/有機カチオン交換輸送体の基質認識性についての検討
(日本薬剤学会第34年会 2019)
Expression and functional characterization of SLC transporters in brain microvascular endothelial cells derived from human induced pluripotent stem cells.
(13th International Conference on Cerebral Vascular Biology 2019)
Drug discovery of pyrilamine derivatives as blood-brain barrier permeable histone deacetylase inhibitors.
(27th International Society of Heterocyclic Chemistry Congress 2019)

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Professional career (1)：

Work history (3)：

2022/10 - 現在 University of Toyama Faculty of Pharmacy and Pharmaceutical Sciences
2021/04 - 2022/10 University of Kentucky College of Pharmacy Postdoctoral Researcher
2017/04 - 2021/03 Teikyo University Faculty of Pharmaceutical Sciences

Awards (3)：

Association Membership(s) (3)：

日本薬剤学会 , 日本薬物動態学会 , 日本薬学会

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