2018 - 2020 Elucidation of physiological roles of fatty acyl species of late endosome-specific phospholipid BMP
2017 - 2020 The impact of lipid composition alteration via beta-oxidation failure on the pathophysiological linkage between nonalcoholic steatohepatitis and sarcopenia
2015 - 2017 Functional analysis of docosahexaenoic acids in late-endosome specific phospholipid BMP
2016 - 2017 Association between atrial fibrillation and DHA-containing phospholipids
2008 - 2010 生体膜リン脂質分子種多様性構築の分子機構とその生物学的意義の解明
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Papers (52)：
Fumiya Takahashi, Takashi Baba, Antonius Christianto, Shogo Yanai, Hyeon-Cheol Lee-Okada, Keisuke Ishiwata, Kazuhiko Nakabayashi, Kenichiro Hata, Tomohiro Ishii, Tomonobu Hasegawa, et al. Development of sexual dimorphism of skeletal muscles through the adrenal cortex, caused by androgen-induced global gene suppression. Cell Reports. 2024. 43. 2. 113715-113715
Yoshihiro Ishida, Kazuko Saeki, Marina Ueda, Hyeon-Cheol Lee-Okada, Hiromi Doi, Naotomo Kambe, Saeko Nakajima, Takehiko Yokomizo, Kenji Kabashima. CYP4F22 p.V215D is a novel variant causative for lamellar ichthyosis. Journal of the European Academy of Dermatology and Venereology. 2023
Deepa Jonnalagadda, Yasuyuki Kihara, Aran Groves, Manisha Ray, Arjun Saha, Clayton Ellington, Hyeon-Cheol Lee-Okada, Tomomi Furihata, Takehiko Yokomizo, Edward V. Quadros, et al. FTY720 requires vitamin B12-TCN2-CD320 signaling in astrocytes to reduce disease in an animal model of multiple sclerosis. Cell Reports. 2023. 42. 12. 113545-113545
Hirona Yamamoto, Hyeon-Cheol Lee-Okada, Masashi Ikeda, Takumi Nakamura, Takeo Saito, Atsushi Takata, Takehiko Yokomizo, Nakao Iwata, Tadafumi Kato, Takaoki Kasahara. GWAS-identified bipolar disorder risk allele in the FADS1/2 gene region links mood episodes and unsaturated fatty acid metabolism in mutant mice. Molecular Psychiatry. 2023. 28. 7. 2848-2856
Ryosuke Ishimura, Afnan H El-Gowily, Daisuke Noshiro, Satoko Komatsu-Hirota, Yasuko Ono, Mayumi Shindo, Tomohisa Hatta, Manabu Abe, Takefumi Uemura, Hyeon-Cheol Lee-Okada, et al. The UFM1 system regulates ER-phagy through the ufmylation of CYB5R3. Nature communications. 2022. 13. 1. 7857-7857
Generation and application of animal models for a comprehensive and systematic understanding of physiological functions of polyunsaturated fatty acids
(2022)
雄性生殖における脂肪酸輸送体 (FATP1)の役割の解明
(第95回日本生化学会大会)
HDSF inhibits the activity of LYPLA1 and LYPLA2
(JCBL2022 2022)
The regulatory mechanism of Hormone-sensitive lipase (HSL) in 10T1/2 cell
(JCBL2022 2022)
The anti-HCV drug sofosbuvir inhibits Hormone-sensitive lipase
(JCBL2022 2022)
