Rchr
J-GLOBAL ID：201701010695477780   Update date: Feb. 14, 2024

Ishimoto Takuji

Ishimoto Takuji
Affiliation and department：
Aichi Medical University Department of Nephrology and Rheumatology

About Aichi Medical University Department of Nephrology and Rheumatology


Job title： Associate Professor
Research field  (2)： Metabolism and endocrinology ,  Nephrology
Research keywords  (1)： Metabolic syndrome//Diabetes/CKD/nephrotic syndrome/nucleic acid drug
Research theme for competitive and other funds  (13)：
  • 2023 - 2026 過剰塩分摂取に起因するCKDにみられる炎症の全身臓器障害の病態解明
  • 2022 - 2025 内皮細胞障害に着目したCKD血管石灰化メカニズムの解析と標的治療の確立
  • 2021 - 2024 間葉系幹細胞の微小環境での炎症制御機構に着眼した次世代型免疫・炎症制御法の創成
  • 2021 - 2024 内皮細胞Glycocalyxをターゲットとした腎疾患の新たな治療戦略の確立
  • 2021 - 2024 Elucidation of the mechanism of peritoneal dialysis-related peritoneal injury through complement pathway and establishment of novel anti-complement therapy.
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Papers (96)：
  • Makoto Yamaguchi, Takaaki Obayashi, Naoto Kobayashi, Naoki Izumi, Masaaki Nagai, Hironobu Nobata, Akimasa Asai, Keisuke Kamiya, Hirokazu Sugiyama, Hiroshi Kinashi, et al. Association between reduced left ventricular ejection fraction and peritoneal dialysis related peritonitis: a single center retrospective cohort study in Japan. Scientific reports. 2023. 13. 1. 22697-22697
  • Yasuhiko Ito, Ting Sun, Hiroya Tanaka, Makoto Yamaguchi, Hiroshi Kinashi, Fumiko Sakata, Shunnosuke Kunoki, Yukinao Sakai, Takuji Ishimoto. Tissue Sodium Accumulation Induces Organ Inflammation and Injury in Chronic Kidney Disease. International journal of molecular sciences. 2023. 24. 9
  • Kentaro Imai, Takuji Ishimoto, Tomohito Doke, Toshiki Tsuboi, Yu Watanabe, Keisuke Katsushima, Miho Suzuki, Hideto Oishi, Kazuhiro Furuhashi, Yasuhiko Ito, et al. Long non-coding RNA lnc-CHAF1B-3 promotes renal interstitial fibrosis by regulating EMT-related genes in renal proximal tubular cells. Molecular therapy. Nucleic acids. 2023. 31. 139-150
  • Makoto Yamaguchi, Mayumi Ito, Hirokazu Sugiyama, Shiho Iwagaitsu, Hironobu Nobata, Hiroshi Kinashi, Takayuki Katsuno, Shogo Banno, Yasuhiko Ito, Masahiko Ando, et al. Malnutrition according to the GLIM criteria with kidney dysfunction is associated with increased mortality in hospitalized patients with cardiovascular disease: a retrospective cohort study. Clinical Nutrition Espen. 2023. 55. 167-173
  • Shunnosuke Kunoki, Hideki Tatsukawa, Yukinao Sakai, Hiroshi Kinashi, Tetsuyoshi Kariya, Yasuhiro Suzuki, Masashi Mizuno, Makoto Yamaguchi, Hiroyuki Sasakura, Masashi Ikeno, et al. Inhibition of Transglutaminase 2 Reduces Peritoneal Injury in a Chlorhexidine-Induced Peritoneal Fibrosis Model. Laboratory investigation; a journal of technical methods and pathology. 2023. 103. 4. 100050-100050
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MISC (24)：
  • Funahashi Yoshio, Kato Noritoshi, Kitai Hiroki, Ishimoto Takuji, Kosugi Tomoki, Tsuboi Naotake, Matsuda Naoyuki, Maruyama Shoichi, Kadomatsu Kenji. MIR-146A TARGETING SPLENIC MACROPHAGES PREVENTS SEPSIS-INDUCED MULTIPLE ORGAN INJURY INCLUDING ACUTE KIDNEY INJURY. SHOCK. 2018. 49. 6. 21-21
  • Doke Tomohito, Ishimoto Takuji, Hayasaki Takahiro, Johnson Richard, Maruyama Shoichi. LACKING OF KETOHEXOKINASE AMELIORATED THE RENAL LIPID ACCUMULATION IN HIGH-FAT DIET FED STREPTOZOTOCIN INDUCED DIABETIC MICE. NEPHROLOGY DIALYSIS TRANSPLANTATION. 2018. 33. .
  • Hayasaki Takahiro, Ishimoto Takuji, Doke Tomohito, Lanaspa Miguel, Johnson Richard, Maruyama Shoichi. FRUCTOSE METABOLISM INCREASES BLOOD PRESSURE BY THE UPREGULATION OF RENAL SODIUM REABSORPTION IN MICE. NEPHROLOGY DIALYSIS TRANSPLANTATION. 2018. 33. .
  • 水野 正司, 鈴木 康弘, 坂田 史子, 鬼無 洋, 吉岡 知輝, 勝野 敬之, 加藤 規利, 石本 卓嗣, 小杉 智規, 坪井 直毅, et al. 重症再生不良性貧血の患者に、腹膜透析を導入した一例. 医工学治療. 2018. 30. Suppl. 153-153
  • 勝野 敬之, 加藤 規利, 石本 卓嗣, 小杉 智規, 安田 宜成, 坪井 直毅, 伊藤 恭彦, 丸山 彰一. 生体腎移植後に診断されたproliferative glomerulonephritis with monoclonal IgG deposits(PGNMID). 日本腎臓学会誌. 2017. 59. 6. 721-721
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Patents (1)：
  • Methods and compositions for the inhibition of fructokinase
Lectures and oral presentations  (10)：
  • LACKING OF KETOHEXOKINASE AMELIORATED THE RENAL LIPID ACCUMULATION IN HIGH-FAT DIET FED STREPTOZOTOCIN INDUCED DIABETIC MICE
    (NEPHROLOGY DIALYSIS TRANSPLANTATION 2018)
  • FRUCTOSE METABOLISM INCREASES BLOOD PRESSURE BY THE UPREGULATION OF RENAL SODIUM REABSORPTION IN MICE
    (NEPHROLOGY DIALYSIS TRANSPLANTATION 2018)
  • A CASE OF RAPIDLY PROGRESSIVE NEPHRITIC SYNDROME AND NEPHROTIC SYNDROME DURING THE TREATMENT OF DERMATOMYOSITIS AND DIABETES
    (RHEUMATOLOGY 2017)
  • CD147/Basigin Deficiency Prevents the Development of Podocyte Injury through the Integrin/FAK Signaling Pathway
    (Kidney Week 2016 2016)
  • Lacking Fructokinase-A Exacerbates Renal Injury in Streptozotocin-Induced Diabetic Mice
    (Kidney Week 2016 2016)
ｍore...
Education (2)：
  • 2004 - 2008 Nagoya University Graduate School, Division of Medical Sciences Department of Nephrology (Integrated Molecular Medicine)
  • 1991 - 1997 Nagoya University Faculty of Medicine
Work history (6)：
  • 2022/04 - 現在 Aichi Medical University Department of Nephrology and Rheumatology Professor
  • 2021/06 - 2022/03 Aichi Medical University Department of Nephrology and Rheumatology Associate Professor
  • 2018/09 - 2021/05 Nagoya University Nagoya University Hospital Nephrology Lecturer
  • 2016/07/01 - 2018/08/31 Nagoya University Nagoya University Hospital Nephrology Assistant Professor
  • 2014/04/01 - 2016/06/30 Nagoya University Nagoya University Hospital Nephrology Assistant professor of hospital
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Association Membership(s) (5)：
米国腎臓学会 ,  日本リウマチ学会 ,  日本透析医学会 ,  日本腎臓学会 ,  日本内科学会
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