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J-GLOBAL ID：201701011200164574 Update date: Mar. 31, 2025

NAKAJIMA MADOKA

ナカジママドカ | NAKAJIMA MADOKA

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Affiliation and department：
Job title：准教授
Other affiliations (1)：

東フィンランド大学脳神経外科学客員研究員

Homepage URL (1)： https://functionalneurosurgeryjuntendouniversity.wordpress.com/

Research field (3)： General surgery, pediatric surgery , Neuroscience - general , Basic brain sciences

Research keywords (5)： Cerebrospinal fluid , Neurosurgery , Hydrocephalus , Epilepsy , Dementia

Research theme for competitive and other funds (33)：

2024 - 2027 Diagnosis of Transchoroidal Plexus Protein Clearance Disorders and Improvement of Excretory Capacity Therapy
2022 - 2025 脳脊髄液漏出症の高精度・非侵襲的な新規診断法開発のためMRI・蛋白解析研究
2022 - 2025 認知症診療医のための「特発性正常圧水頭症の鑑別診断とアルツハイマー病併存診断、および診療連携構築のための実践的手引き書と検査解説ビデオ」作成研究
2022 - 2025 Early diagnosis and prevention of dementia through onomatopoeic detection of decline in qualitative cognitive abilities
2022 - 2024 Explore Impact of Head Motion on Cerebrospinal Fluid Dynamics using Simulation and Real-Time Medical Imaging

2021 - 2024 脳における老廃物蓄積の可視化による認知症の早期診断法の基盤構築

2021 - 2024 補正因子を検出し発作拡延脳波より真のてんかん焦点を同定する

2020 - 2023 髄液及び脳からの老廃物の排泄の改善による認知症発症の予防

2020 - 2023 神経毒性蛋白排出障害による神経変性機序の解明と新規排出促進の理論基盤の確立

2020 - 2023 AIとIoTにより認知症高齢者問題を多面的に解決する東京アプローチの確立

2020 - 2023 加齢性認知機能障害に対する新規治療法の開発を目的とした糖蛋白LRGの機能解析

2017 - 2022 Development of AI-based diagnosis and treatment-aid for epilepsy by automated interpretation of electroencephalogram

2018 - 2021 Cerebral deposition due to excrete promotion indicated by cerebrospinal fluid metabolic pathway impairment of neurotoxic protein

2018 - 2021 Functional MRI and diffusion MRI analysis of motor function plasticity and networks utilizing machine learning.

2018 - 2021 Establishment of biomarker diagnosis and severity classification in cerebrospinal fluid of patients with idiopathic normal pressure hydrocephalus

2017 - 2020 Potential cerebrospinal fluid marker for discriminating Parkinson syndrome from idiopathic normal pressure hydrocephalus based on microRNA search

2017 - 2020 Analysis of new pathological phenomena in adult onset temporal lobe epilepsy and the potential therapeutic effect of glycated protein expression control

2017 - 2020 The research committee of idiopathic normal pressure hydrocephalus : For the establishment of the new guideline (3rd issue)

2017 - 2020 成人二次性側頭葉てんかんに関する新たな病態解析と糖化蛋白発現調整の新治療応用

2018 - 2019 Analysis for temporal lobe epilepsy with enlarged amygdala

2017 - 2019 高齢発症のてんかん原性形成に関与する脳内慢性炎症の病理組織解析

2015 - 2018 Research for mechanism of speech acquisition using new generation diffusion MRI and functional MRI

2017 - 2018 Histopathological analysis of chronic inflammation in the brain(Fostering Joint International Research)

2014 - 2017 Establishment of diagnostic method and pathophysiology for idiopathic normal pressure hydrocephalus

2014 - 2017 Inflammation and ischemia are Involved in the onset of epilepsy

2014 - 2017 Development of DBS programming based on local field potential analysis

2014 - 2017 てんかん発作誘導が獲得するてんかん原性と慢性炎症〜てんかん原性を予防する脳内環境

2012 - 2015 Role of synaptic vesicle 2A protein to obtain epileptogenesis through neurogenesis in hippocampus

2011 - 2014 Is it possible to induce neuronal cell death to attenuate the activity, the new born neurons that acquire epileptogenic?

2011 - 2013 Inflammatory pathways control role in epileptogenic neuronogenesis

2008 - 2011 Dentate neurogenesis and neural maturation in animal models of epilepsy

2009 - 2011 Transduction of neurogenesis inducing gene to the hippocampus

2008 - 2010 Dentate neurogenesis and neural maturation in animal models of epilepsy

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Papers (263)：

Tomoyo Shimada, Anri Sakurai, Shunichi Niiyama, Kaito Kawamura, Madoka Nakajima, Ayami Okuzumi, Taku Hatano, Masakazu Miyajima, Nobutaka Hattori, Taiji Tsunemi. Idiopathic normal pressure hydrocephalus concomitant with progressive supranuclear palsy. Parkinsonism & related disorders. 2025. 132. 107273-107273
Koichiro Sakamoto, Masakazu Miyajima, Madoka Nakajima, Ikuko Ogino, Kou Horikoshi, Ryo Miyahara, Kaito Kawamura, Kostadin Karagiozov, Chihiro Kamohara, Eri Nakamura, et al. Loss of Dnah5 Downregulates Dync1h1 Expression, Causing Cortical Development Disorders and Congenital Hydrocephalus. Cells. 2024
高山敏樹, 廣瀬匠, 後藤政実, 代田浩之, 中島円, 村上康二, 本井ゆみ子. 認知症外来における臨床的アルツハイマー病画像診断の脳内アミロイド集積予測能検討. Dementia Japan. 2024. 38. 4. 675-675
Ryohei Fukuma, Takufumi Yanagisawa, Hidenori Sugano, Kentaro Tamura, Satoru Oshino, Naoki Tani, Yasushi Iimura, Hui Ming Khoo, Hiroharu Suzuki, Huixiang Yang, et al. Image retrieval based on closed-loop visual-semantic neural decoding. 2024
蒲原千尋, 中島円, 川村海渡, 山田茂樹, 青山幸彦, 宮嶋雅一, 近藤聡英. ストループテストアプリケーションを用いた特発性正常圧水頭症患者に対する前頭葉機能評価. 高次脳機能研究. 2024. 44. 1. 99-100

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MISC (142)：

河合亮, 中島円, 山田茂樹, 貴島晴彦, 上羽哲也, 中村夏子, 南まりな, 數井裕光. 我が国の脳神経外科施設における特発性正常圧水頭症(idiopathicnormal pressure hydrocephalus:iNPH)診療に関する実態調査. 日本正常圧水頭症学会プログラム・抄録集. 2024. 25th
蒲原千尋, 中島円, 川村海渡, 山田茂樹, 青柳幸彦, 宮嶋雅一, 近藤聡英. 特発性正常圧水頭症患者におけるストループテストアプリケーションの検証. 日本正常圧水頭症学会プログラム・抄録集. 2023. 24th
菊田潤子, 鎌形康司, 高林海斗, 内田航, 和田昭彦, 川村海渡, 秋葉ちひろ, 中島円, 宮嶋雅一, 青木茂樹. 特発性正常圧水頭症のLPシャント術前後における脈絡叢体積変化の検討. 日本神経放射線学会プログラム・抄録集. 2022. 51st
菅野秀宣, 中島円, 松井亮祐, 田中聡久. Proof of concept report on the online EEG reporting system. てんかん研究. 2022. 40. 2
菅野秀宣, 鈴木皓晴, 飯村康司, 中島円, 田中聡久. Robotic device for SEEG, Rosa One. てんかん研究. 2022. 40. 2

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Books (12)：

Normal Pressure Hydrocephalus,
Springer Nature (Switzerland AG) 2023
脳神経外科学レビュー : 最新主要文献でみる
総合医学社 2022 ISBN:9784883787494
Annual Review神経
中外医学社 2022 ISBN:9784498328822
Clinical Neuroscience
2020
特発性正常圧水頭症診療ガイドライン
メディカルレビュー社 2020 ISBN:9784779223761

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Lectures and oral presentations (104)：

ドパミントランスポーター集積分布による特発性正常圧水頭症治療の長期予後予測
(第41回日本認知症学会学術集会第37回日本老年精神医学会[合同開催] 2022)
特発性正常圧水頭症の脳機能画像の有用性について
(第25回愛媛脳SPECT・PET研究会 2022)
特発性正常圧水頭症のホットトピック~どんな研究が論文になるか
(第9回ちばiNPH研究会 2022)
認知症と脳脊髄液による生理活性蛋白クリアランス:慢性水頭症動物モデルと脳脊髄液バイオマーカーによる取り組み.
(The 81st Annual Meeting of the Japan Neurosurgical Society 2022)
特発性正常圧水頭症治療としてシャントシステムに何を期待するのか?
(第20回日本臨床医療福祉学会 2022)

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Education (1)：

1991 - 1997 Jutendo University School of Medicine

Professional career (1)：

M.D., Ph.D. (Juntendo University)

Work history (4)：

2013/01 - 現在 Juntendo University Department of Neurosurgery Associate Professor
2018/04 - 2018/12 University of Eastern Finland Neurosurgery Visiting Professor
2007/04 - 2012/12 Juntendo University Department of Neurosurgery Assistant professor
1997/05 - 2007/03 Juntendo University Department of Neurosurgery Research associate

Committee career (4)：

2022/06 - 現在日本正常圧水頭症学会理事理事
2020/11 - 現在 Japanese Society for Neuroendoscopy (JSNE) Technical Certification Committee (Chairman)
2019/11 - 現在 Japanese Society for Neuroendoscopy (JSNE) member of publicity committee
2017 - 現在 The Japan Epilepsy Society councillor

Awards (6)：

2021/10 - English Presentation Award Expression of the leucine-rich alpha2 glycoprotein in the hippocampus prevents decreased cognitive function after status epilepticus.
2017/11 - Japan Society for Dementia Research encouragement award Shunt treatment for possible idiopathic normal pressure hydrocephalus improves patient outcome in a manner that outperforms age-associated surgical risks
2015/04 - the Japan Neuroscience Foundation Grant-in-Aid for General Research on the Japan Neuroscience Foundation Elucidation of the mechanism of congenital hydrocephalus development by embryonic H-Tx rats
2014/06 - Japanese Geriatrics Society Japan Geriatrics Medical Association Novartis Award for Geriatrics Research and Geriatricsl Research Foundation Leucine-rich α2 -glycoprotein overexpression in the brain contributes to memory impairment.
2013/10 - Japan Neurosurgical Society The 72nd General Assembly Chairman's Award of the Japan Neurosurgical Society Accelerated cerebrospinal fluid turnover lowers amyloid β dimer concentration in iNPH

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Association Membership(s) (10)：

Japanese society of NPH , The Japan Neurosurgical Society , Epilepsy Surgery Society of Japan , JAPAN SOCIETY FOR STEREOTACTIC AND FUNCTIONAL NEUROSURGERY , Japanese Society for Neuroendoscopy (JSNE) , American Epilepsy Society , JAPAN SOCIETY FOR DEMENTIA RESEARCH , JAPAN EPILEPSY SOCIETY , Japanese Society of Pediatric Neurosurgery , Japan Society of Child Neurology

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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