2018 - 2021 Basic study of CAR-NK cell therapy derived from iPS cells.
2018 - 2020 Development of PD-1 gene-disrupted EGFRvIII-specific CAR-T cell-based immunotherapy against glioblastoma
2019 - 2019 Development of a novel immunotherapy against glioblastoma: Producing of PD-1-disrupted T cells carrying chimeric antigen receptor targeting EGFRvIII
2016 - 2019 Development of immunotherapy for glioblastoma using EGFRvIII specific CAR transduced immune cells
2016 - 2019 Combined therapy with natural killer cell and anti PD-1 antibody for glioblastoma
2016 - 2018 Novel therapeutic approach for glioblastoma with iPS cells-derived CAR-T cells
2014 - 2017 Tumor-Inhibition Effect of Levetiracetam in Combination with Temozolomide in Glioblastoma Cells
2014 - 2016 New approach for glioblastoma with immuno-chemotherapy using severe immunodeficiency mouse
Show all
Papers (35)：
Tsutomu Nakazawa(corresponding author), Takayuki Morimoto, Ryosuke Maeoka, Kengo Yamada, Ryosuke Matsuda, Mitsutoshi Nakamura, Fumihiko Nishimura, Shuichi Yamada, Young-Soo Park, Takahiro Tsujimura, et al. Characterization of HIF-1α knockout primary human natural killer cells including populations in allogeneic glioblastoma. International Journal of Molecular Sciences. 2024. 25. 11. 5896
Ryosuke Matsuda, Ryosuke Maeoka, Takayuki Morimoto, Tsutomu Nakazawa, Yudai Morisaki, Shohei Yokoyama, Masashi Kotsugi, Yasuhiro Takeshima, Shuichi Yamada, Fumihiko Nishimura, et al. Pre-treatment systemic inflammation response index and systemic immune inflammation in patients with primary central nerve system lymphoma as a useful prognostic indicator. Journal of Neuro-Oncology. 2024
Ryosuke Matsuda, Ryosuke Maeoka, Takayuki Morimoto, Tsutomu Nakazawa, Yudai Morisaki, Kenta Nakase, Shohei Yokoyama, Masashi Kotsugi, Yasuhiro Takeshima, Shuichi Yamada, et al. Preoperative blood counts predict overall survival in patients undergoing surgical removal of brain metastasis. World Neurosurgery. 2024
Ryosuke Matsuda, Masatoshi Hasegawa, Tetsuro Tamamoto, Nobuyoshi Inooka, Takayuki Morimoto, Ryosuke Maeoka, Tsutomu Nakazawa, Tomoko Ochi, Toshiteru Miyasaka, Shigeto Hontsu, et al. Clinical Results and Hematologic Predictors of Linear Accelerator-Based Stereotactic Radiosurgery or Fractionated Stereotactic Radiotherapy for Brain Metastasis in Patients Aged 75 Years or Older: A Retrospective Study. World Neurosurgery. 2024. 183. e944-e952
CISH knockout by CRISPR/Cas9 enhances human peripheral blood-derived NKcell functions against allogeneic glioblastoma
(International Scoiety for Cell & Gene Therapy (ISCT) 2024)
Characterization of CISH-knockout NK cells derived from human peripheralblood and evaluated the antitumor effects in allogeneic glioblastoma
(The Annual Meeting of The American Association of Immunologists; IMMUNOLOGY2024)
Efficient feeder-free expansion system for highly purified NK cells derived from human cord blood
(The 23rd The Annual Meeting of the Japanese Society for Regenerative Medicine 2024)
Antitumor effects of CIS-knockout human allogeneic NK cells in GBM
(2023)
Evaluation of Comprehensive Gene Expression and NK Cell-Mediated Killing in Glioblastoma Cell Line-Derived Spheroids
(2023)
- 2015 Nara medical university graduate school of medicine
- 2005 Osaka university graduate school of medicine
Professional career (1)：
医学博士 (奈良県立医科大学)
Work history (5)：
2023/01 - 現在 日本再生医療学会 代議員
2022/03 - 現在 Nara Medical University
2020 - 現在 日本再生医療学会 上級臨床培養士
2018/01 - 現在 日本再生医療学会 臨床培養士
2015/04 - 現在 Nara Medical University Neurosurgery Research Scientist
Committee career (4)：
2022/11 - 現在 The Japanese Society for Regenerative Medicine Delegate
2021/11 - 現在 International Journal of Molecular Sciences Reviewer Board
2019/12 - 現在 Journal of Drug Targeting Referee boad
2019/03 - 現在 National Science Center (Poland) Research Project Referee Board
Awards (5)：
2024/01 - The Hitachi Global Foundation Kurata incentive grant
2023/12 - International Journal of Molecular Science Trusted Reviewer
2023/12 - International Journal of Molecular Science Latest Review Award
2017/04 - 奈良県立医科大学脳神経外科 堀賞 (基礎研究部門)
2015/04 - 奈良県立医科大学脳神経外科 堀賞 (基礎研究部門)
Association Membership(s) (8)：
JAPANESE ASSOCIATION OF CANCER IMMUNOLOGY
, THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE
, THE JAPANESE SOCIETY FOR IMMUNOLOGY
, THE JAPANESE CANCER ASSOCIATION
, 日本遺伝子細胞治療学会
, 日本血液疾患免疫療法学会
, 日本ゲノム編集学会
, Japan Research Association for Immunotherapeutics
