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J-GLOBAL ID：201701014624038179 Update date: Jan. 04, 2025

Mizunoe Yuhei

ミズノエユウヘイ | Mizunoe Yuhei

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Research field (3)： Nutrition and health science , Pharmaceuticals - health and biochemistry , Metabolism and endocrinology

Research keywords (11)：カテプシン , リソソーム , コレステロール , 脂質異常症 , 脂肪細胞 , ミトコンドリア , 二型糖尿病 , 骨格筋 , 老化 , オートファジー , 脂肪組織

Research theme for competitive and other funds (5)：

2023 - 2025 ”免疫様脂肪細胞”によるリソソーム機能障害と肥満症病態基盤の形成
2019 - 2022 骨格筋でのコレステロール合成阻害が導く新たなコレステロール代謝機構
2018 - 2021 加齢によるリソソーム機能破綻が骨格筋に及ぼす影響の解明とその制御法の開発
2019 - 2020 骨格筋特異的コレステロール破綻が横紋筋融解症を発症させる分子メカニズムの解明
2017 - 2018 サルコペニアにおける筋繊維タイプ変化・代謝変換とオートファジー相互作用機構の解明

Papers (29)：

Yuka Nozaki, Fumika Suwa, Kazuhiro Furuya, Masahiro Komeno, Shunsuke Hoshino, Yuhei Mizunoe, Kyohei Higashi, Masaki Kobayashi, Yoshikazu Higami. The effects of WWP1 overexpression on the golgi apparatus stress response and proteoglycan production in adipocytes. Scientific reports. 2024. 14. 1. 29004-29004
Yasuhisa Furuta, Yoshinori Osaki, Yoshimi Nakagawa, Song-Iee Han, Masaya Araki, Akito Shikama, Nami Ohuchi, Daichi Yamazaki, Erika Matsuda, Seitaro Nohara, et al. Genetic and Functional Analyses of Patients with Marked Hypo-High-Density Lipoprotein Cholesterolemia. Journal of atherosclerosis and thrombosis. 2024
Kazuki Hachiya, Yusuke Deguchi, Takuro Hirata, Tomoya Arikawa, Hiroto Fukai, Tatsuhiro Esashi, Kota Nagasawa, Yuhei Mizunoe, Yuka Nozaki, Masaki Kobayashi, et al. Obesity-induced PARIS (ZNF746) accumulation in adipose progenitor cells leads to attenuated mitochondrial biogenesis and impaired adipogenesis. Scientific reports. 2023. 13. 1. 22990-22990
Song-Iee Han, Masanori Nakakuki, Yoshimi Nakagawa, Yunong Wang, Masaya Araki, Yuta Yamamoto, Hiroaki Tokiwa, Hiroyuki Takeda, Yuhei Mizunoe, Kaori Motomura, et al. Rhomboid protease RHBDL4/RHBDD1 cleaves SREBP-1c at endoplasmic reticulum monitoring and regulating fatty acids. PNAS nexus. 2023. 2. 11. pgad351
Yuina Otani, Yuka Nozaki, Yuhei Mizunoe, Masaki Kobayashi, Yoshikazu Higami. Effect of mitochondrial quantity and quality controls in white adipose tissue on healthy lifespan: Essential roles of GH/IGF-1-independent pathways in caloric restriction-mediated metabolic remodeling. Pathology international. 2023

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MISC (5)：

Aging / Lifespan Control by Adipose Tissue. YAKUGAKU ZASSHI. 2024. 144. 4. 411-417
The transcription factor PARIS Inhibits Adipose Progenitor Differentiation and Promotes Cellular Senescence. 47(3); 43-44, 2023【学生優秀発表賞受賞記念文】. 2023. 47. 3. 43-44
Regulation of adipocyte quality by lysosomes and mitochondria. 2021. 45. 1. 31-37
Yuhei Mizunoe, Yuka Sudo, Naoyuki Okita, Yoshikazu Higami. Autophagy in adipose tissue AUTOPHAGY: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, Volume 9 to be published by Elsevier/Academic Press. Autophagy, M.A.HAYAT (ed). 2016. 10. 147-156
水之江雄平, 須藤結香, 平岡秀規, 沖田直之, 樋上賀一. 肥満症脂肪組織におけるリソソーム機能障害とオートファジーに与える影響. 基礎老化研究. 2015. 39. 3. 35-38

Lectures and oral presentations (14)：

Lysosomal dysfunction in obese adipose tissue
(30th Spring International Conference of the Korean Society for Gerontology 2019)
肥満症脂肪組織における脂肪滴局在タンパク質ペリリピン1減少のメカニズム解明(ポスター)
(第42回日本基礎老化学会大会 2019)
臓器特異的SREBP-1a欠損マウスを用いたSREBP-1aの肝臓における機能解(ポスター)
(第56回日本臨床分子医学会学術集会 2019)
新規プロテアーゼによるSREBP-1活性化制御機構の解明(ポスター)
(第56回日本臨床分子医学会学術集会 2019)
脂肪酸伸長酵素Elovl6の神経新生における役割(ポスター)
(第56回日本臨床分子医学会学術集会 2019)

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Professional career (1)：

薬科学(博士) (東京理科大学)

Work history (4)：

2023/04 - 現在 Tokyo University of Science Faculty of Pharmaceutical Sciences Department of Medicinal and Life Science Assistant Professor
2022/04 - 2023/03 Tokyo University of Science Organization for Research Advancement Research Institute for Biomedical Science
2019/04 - 2022/03 日本学術振興会特別研究員PD
2018/04 - 2019/03 Faculty of Medicine, University of Tsukuba Department of Internal Medicine (Endocrinology and Metabolism)

Committee career (1)：

2023/03 - 現在日本基礎老化学会評議員

Awards (1)：

2015/06 - 日本基礎老化学会若手奨励賞

Association Membership(s) (4)：

日本動脈硬化学会 , 日本免疫学会 , JAPAN SOCIETY FOR THE STUDY OF OBESITY , JAPAN SOCIETY FOR BIOMEDICAL GERONTOLOGY

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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