Rchr
J-GLOBAL ID：201701015966627350
Update date: Oct. 02, 2024
Takada Shuji
Takada Shuji
Affiliation and department：
Homepage URL (1)：
https://www.ncchd.go.jp/scholar/research/section/ishoku/original/top.html
Research field (1)：
Developmental biology
Research keywords (3)：
ゲノム編集
, ゲノムインプリンティング
, 性決定、性分化
Research theme for competitive and other funds (32)：
- 2024 - 2027 哺乳類の性決定期にSRYがSox9を発現誘導する分子機構の解明
- 2022 - 2025 核酸ワクチンやゲノム編集遺伝子治療に係る安全性の評価と安全な運用に資する研究
- 2021 - 2024 遺伝子改変マウスを用いたMIRAGE症候群における副腎機能低下症の病態解明
- 2021 - 2024 Identification of physiological substrates of osmotic stress-responsive ubiquitin ligase using genome editing, and its involvement in colitis
- 2020 - 2024 生命発動と器官発生・制御に関わるヒト受精胚分子機序の解明
- 2020 - 2023 マウスを用いたヒトSOX9の発現調節機構の解明
- 2020 - 2022 哺乳類常染色体性決定遺伝子Sox9の発現量調節機構の解明
- 2019 - 2022 Molecular basis research for personalized nutrition
- 2019 - 2022 The production and analyses of model mice having new genetic abnormality responsible for adrenal hypoplasia
- 2019 - 2022 Regeneration of the retina and optic nerve by use of retinal ganglion cells generated from human iPS cells
- 2019 - 2022 A novel sex-determining mechanism in the mammalian species lacking SRY
- 2018 - 2022 Regulatory mechanism of mTOC1 signaling by ubiquitin ligase RNF182 involved in neural differentiation
- 2018 - 2021 The pathogenesis of MIRAGE syndrome revealed by model mice using genome editing
- 2018 - 2021 Elucidation of the function of miRNAs at the 14q32.2 imprinted region in the placental development and hepatoblastoma development
- 2018 - 2021 Generation and characterization of BCOR-ITD tumor models
- 2017 - 2020 Identification and functional analysis of a gonadal Sox9 enhancer
- 2016 - 2019 Development of gene therapy for congenital adrenal hyperplasia using AAV vectors and iPS cells
- 2016 - 2019 Elucidation of pathogenic mechanisms of disorders of sex development using systematic molecular analysis
- 2016 - 2019 Identification of a new gene for 46,XY disorders of sex development
- 2016 - 2018 Mechanisms of tumorigenesis through novel BCOR abnormality in clear cell sarcoma of the kidney
- 2015 - 2018 Elucidation of the onset mechanism of human imprinting disorders using the method of methylation analysis with high-density DNA methylation arrays
- 2015 - 2018 Mouse polycomb targets in gonadal development
- 2013 - 2017 KLF14 biology: its physiological roles and transcriptional regulation
- 2014 - 2016 Functional analysis of microRNA in gonadogenesis and gonadal function.
- 2013 - 2015 マウス全転写因子の発現解析をもとにした性差構築の分子機構の解明
- 2011 - 2014 Analysis of Muscle and Tendon Development and its application to Medicine
- 2011 - 2013 マウス全転写因子の発現解析をもとにした性差構築機構の解明
- 2011 - 2013 Molecular network and functional analysis of gonad specific microRNA
- 2011 - 2012 Dlk1-Dio3インプリント制御領域の機能解析
- 2009 - 2010 ヒト生殖系列におけるインプリンティング制御機構の解明
- 2008 - 2010 Elucidation of the pathogenic mechanism and the clinical spectrum of disorders associated with imprinted genes on human chromosome 14
- 2008 - 2010 Functional analysis of microRNAs on sex determination and differentiation
Show all
Papers (147)：
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Taiki Abe, Kaho Morisaki, Tetsuya Niihori, Miho Terao, Shuji Takada, Yoko Aoki. Dysregulation of RAS proteostasis by autosomal-dominant LZTR1 mutation induces Noonan syndrome-like phenotypes in mice. JCI Insight. 2024
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Masamichi Ito, Manami Katoh, Tatsuro Sassa, Toshiyuki Ko, Kanna Fujita, Shintaro Yamada, Koichiro Miura, Masashi Toyoda, Shuji Takada, Takashige Tobita, et al. LMNA Q353R Mutation Causes Dilated Cardiomyopathy Through Impaired Vitamin D Signaling. Circulation. 2024. 150. 12. 971-974
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Noboru Uchida, Tomohiro Ishii, Naoko Amano, Shuji Takada, Kyoko Kobayashi, Tomoaki Murakami, Satoshi Narumi, Tomonobu Hasegawa. Znrf3 exon 2 deletion mice do not recapitulate congenital adrenal hypoplasia. Journal of molecular endocrinology. 2024
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Tomoyo Yoshida, Tadashi Yokoi, Taku Tanaka, Emiko Matsuzaka, Yuki Saida, Sachiko Nishina, Shuji Takada, Shigeomi Shimizu, Noriyuki Azuma. Modeling of Retina and Optic Nerve Ischemia-Reperfusion Injury through Hypoxia-Reoxygenation in Human Induced Pluripotent Stem Cell-Derived Retinal Ganglion Cells. Cells. 2024. 13. 2
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Tsuji-Hosokawa A, Tsuchiya I, Shimizu K, Terao M, Yasuhara M, Miyamoto N, Kikuchi S, Ogawa Y, Nakamura K, Matsubara Y, et al. Genetically humanized phenylketonuria mouse model as a testing tool for human genome editing in fertilized eggs. Journal of Inherited Metabolic Disease. 2024
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MISC (5)：
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高田修治. ミニレビュー 生化学哺乳類の性決定におけるSox9のエンハンサーによる発現制御. 生化学. 2024. 96. 4. 571-575
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阿部太紀, 菅野新一郎, 新堀哲也, 寺尾美穂, 高田修治, 青木洋子. Dysregulation of RAS proteostasis induces tumor growth and metastasis. 日本薬学会年会要旨集(Web). 2024. 144th
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土屋育, 土屋育, 辻敦美, 辻敦美, 高田修治, 高田修治. Analyses of regulatory systems of Sox9/SOX9 expression in testicular development. 月刊細胞. 2024. 56. 1
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辻敦美, 辻敦美, CHEN Junlong, 中谷久恵, 中谷久恵, 平林美香, 寺尾美穂, 土屋育, 土屋育, 高田修治. The single nucleotide variant, Rspo1 Arg111Tyr, deteriorated RSPO1 function in fetal gonads and promoted fetal Leydig cell differentiation in XX mice. 日本分子生物学会年会プログラム・要旨集(Web). 2022. 45th
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柳井翔吾, 馬場崇, 馬場崇, 井上実紀, 井上実紀, 高橋史也, 寺尾美穂, 高田修治, 石渡啓介, 中林一彦, et al. UTY, the histone demethylase encoded by the Y chromosome, regulates expression of immediate early genes in testicular Leydig cells without its histone demethylation activity. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th
Education (3)：
- 1995 - 1999 北海道大学大学院 地球環境科学研究科 生態環境科学専攻
- 1992 - 1994 Kyoto Pharmaceutical University
- 1988 - 1992 Kyoto Pharmaceutical University Pharmaceutical Sciences Pharmaceutical Biology
Professional career (1)：
Work history (6)：
Awards (2)：
- 2007 - 自治医科大研究奨励賞受賞
- 2006 - 第68回日本血液学会・第48回日本臨床血液学会合同総会奨励賞受賞
Association Membership(s) (3)：
日本ゲノム編集学会
, 日本エピジェネティクス研究会
, THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
