Shintaku Hirofumi

Affiliation and department：
Job title： Professor
Other affiliations (1)：

RIKEN Cluster for Pioneering Research RIKEN Hakubi Research Team Leader

Homepage URL (1)： https://www.hshintaku.com/

Research field (3)： Nanobioscience , Biophysics , Fluid engineering

Research keywords (5)： RNA , Single cell , Microfluidics , MEMS , Fluid Engineering

Research theme for competitive and other funds (14)：

2021 - 2024 ナノ電気穿孔を用いた1細胞ダイナミクス計測法の創成
2021 - 2023 ヘテロな肝細胞の生理学的役割分担の解明と創薬や医療への応用
2019 - 2022 Electrophoretic analysis on cytoplasmic molecules and organelles in single cells using microfluidic fractionation
2019 - 2021 The dynamics of RNA transport in single cells
2014 - 2019 Micro and nano electroporation for direct delivery of molecules to cell nucleus

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Papers (69)：

Akifumi Shiomi, Taikopaul Kaneko, Kaori Nishikawa, Arata Tsuchida, Takashi Isoshima, Mayuko Sato, Kiminori Toyooka, Kentaro Doi, Hidekazu Nishikii, Hirofumi Shintaku. High-throughput mechanical phenotyping and transcriptomics of single cells. Nature Communications. 2024. 15. 1. 3812-3812
Arata Tsuchida, Taikopaul Kaneko, Kaori Nishikawa, Mayu Kawasaki, Ryuji Yokokawa, Hirofumi Shintaku. Opto-combinatorial indexing enables high-content transcriptomics by linking cell images and transcriptomes. Lab on a chip. 2024. 24. 8. 2287-2297
Jianming Chen, Arata Tsuchida, Ali D. Malay, Kousuke Tsuchiya, Hiroyasu Masunaga, Yui Tsuji, Mako Kuzumoto, Kenji Urayama, Hirofumi Shintaku, Keiji Numata. Replicating shear-mediated self-assembly of spider silk through microfluidics. Nature Communications. 2024. 15. 1
Yuji Nashimoto, An Konno, Takuto Imaizumi, Kaori Nishikawa, Kosuke Ino, Takeshi Hori, Hirokazu Kaji, Hirofumi Shintaku, Masafumi Goto, Hitoshi Shiku. Microfluidic vascular formation model for assessing angiogenic capacities of single islets. Biotechnology and bioengineering. 2023
Misa Minegishi, Takahiro Kuchimaru, Kaori Nishikawa, Takayuki Isagawa, Satoshi Iwano, Kei Iida, Hiromasa Hara, Shizuka Miura, Marika Sato, Shigeaki Watanabe, et al. Secretory GFP reconstitution labeling of neighboring cells interrogates cell-cell interactions in metastatic niches. Nature Communications. 2023. 14. 1

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MISC (6)：

Nagendra Kumar Kamisetty, Junya Ikuta, Hirofumi Shintaku, Hidetoshi Kotera, Ryuji Yokokawa, Ryuji Yokokawa. Manipulation of microtubles motility using electrical filed on kiensin/dynein coated surfaces. 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013. 2013. 2. 811-813
Junya Ikuta, Nagendra K. Kamisetty, Hirofumi Shintaku, Hidetoshi Kotera, Ryuji Yokokawa, Ryuji Yokokawa. Microtubule gliding at the boundary of kinesin and dynein patterned surface. 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013. 2013. 3. 1454-1456
Tasuku Nakahara, Naoto Isozaki, Suguru Ando, Nagendra K. Kamisetty, Hirofumi Shintaku, Hidetoshi Kotera, Ryuji Yokokawa, Ryuji Yokokawa. Microtubule manipulation by an electric field in a fused silica channel. 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013. 2013. 1. 161-163
H. Shintaku, Y. Hirabayashi, T. Okitsu, S. Kawano, T. Suzuki, I. Kanno, H. Kotera. A Low Temperature Bonding Technique for Microfluidic Chip Fabrication Using Soft-Cure Su-8 Sheet,. Proceedings of Tenth International Conference on Miniaturized Systems for Chemistry and Life Sciences (microTAS2006), pp. 681-683, Tokyo, Japan, Nov,5-9,. 2006. 681-683
H. Shintaku, S. Kawano, T. Suzuki, I. Kanno, H. Kotera. Dielectrophoretic Electrode Array for Optimum Cell Flow in Pressure Driven Flow. Proceedings of Ninth International Conference on Miniaturized Systems for Chemistry and Life Massachusetts, USA, Oct,9-13,. 2005. 1. 1075-1077

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Patents (7)：

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Lectures and oral presentations (104)：

A high-throughput analysis of cancer-cell dormancy under mechanical confinement with micro-hydrogel beads
(21st IUPAB and 62nd BSJ Joint Congress 2024 (IUPAB 2024) 2024)
Combined analysis of static and dynamic cell-mechanics with unbiased transcriptomics for thousands of single cells
(the 21st IUPAB and 62nd BSJ Joint Congress 2024 2024)
Profiling proliferation phenotype of cancer cells under micro-mechanical confinement with cytometry and sequencing
(International Symposium on Mechanical Control of Biological Self-organization 2024)
Combined analysis of static and dynamic cell mechanics with unbiased transcriptomics for thousands of single cells
(International Symposium on Mechanical Control of Biological Self-organization 2024)
Profiling transcriptomic responses to chemical perturbation by opto-combinatorial indexing
(Serendipity Symposium 2024 2024)

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Education (2)：

2002 - 2006 Kyoto University Graduate School of Engineering Mechanical Engineering
1998 - 2002 Kyoto University Faculty of Engineering School of Engineering Science

Professional career (1)：

Dr. Eng. (Kyoto University)

Work history (7)：

2023/04 - 現在 Kyoto University Institute for Life and Medical Sciences Professor
2018/04 - 現在 RIKEN Cluster for Pioneering Research RIKEN Hakubi Team Leader
2012/04 - 2018/03 Kyoto University Graduate School of Engineering Assistant Professor
2012/09 - 2015/09 Stanford University Department of Mechanical Engineering Visiting Scholar
2007/04 - 2012/03 Osaka University Graduate School of Engineering Science Assistant Professor

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Awards (8)：

2022/02 - 日本機械学会マイクロ・ナノ工学部門優秀講演論文表彰トランスクリプトーム解析を組み合わせた細胞膜の機械特性計測
2018/08 - 第三回ImPACT-シスメックス技術交流会シスメックス賞
2016/03 - 内閣府革新的研究開発推進プログラム「セレンディピティの計画的創出による新価値創造」第一回ImPACT Serendipiter Award
2014/10 - 日本機械学会マイクロ・ナノ工学部門優秀講演論文表彰分子濃縮によるオンチップ電気穿孔法の効率化
2011/08 - 大阪大学大阪大学功績賞

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Association Membership(s) (3)：

THE BIOPHYSICAL SOCIETY OF JAPAN , THE INSTITUTE OF ELECTRICAL ENGINEERS OF JAPAN , THE JAPAN SOCIETY OF MECHANICAL ENGINEERS

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