NAGASAKA AKIOMI

Homepage URL (1)： https://www.med.kobe-u.ac.jp/hsccafe/

Research field (1)： Pharmacology

Research keywords (5)：造血幹細胞 , Heart failure , Carcinoma , macrophages , pH-sensing GPCR

Research theme for competitive and other funds (6)：

2022 - 2025 血管内皮細胞障害を改善する新規機能分子の取得
2019 - 2022 心肥大の退縮を担う分子の探索とその分子メカニズムの解明
2017 - 2021 Analysis of the roles and interaction of various cells including myofibroblasts involved in fibrosis after myocardial infarction
2017 - 2018 腫瘍関連マクロファージにおけるプロトン感知性受容体の生理的役割解析
2013 - 2017 Roles of extracellular environment and various cells carrying different function for cardiac fibrosis

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Papers (16)：

Katsuyuki Nishi, Akiomi Nagasaka, Taro Sakamaki, Kay Sadaoka, Masanori Miyanishi. Isolation Method for Long-Term and Short-Term Hematopoietic Stem Cells. Journal of visualized experiments : JoVE. 2023. 195
Yuma Horii, Shoichi Matsuda, Chikashi Toyota, Takumi Morinaga, Takeo Nakaya, Soken Tsuchiya, Masaki Ohmuraya, Takanori Hironaka, Ryo Yoshiki, Kotaro Kasai, et al. VGLL3 is a mechanosensitive protein that promotes cardiac fibrosis through liquid-liquid phase separation. Nature Communications. 2023. 14. 1
Akiomi Nagasaka, Tsuyoshi Terawaki, Makoto Noda, Miyuki Takashima, Mika Fujino, Yuto Yamauchi, Shigeki Arawaka, Takeo Kato, Michio Nakaya. GRK5 -mediated inflammation and fibrosis exert cardioprotective effects during the acute phase of myocardial infarction. FEBS Open Bio. 2023. 13. 2. 380-391
Noburo Takizawa, Takanori Hironaka, Kyosuke Mae, Tomoyuki Ueno, Yuma Horii, Akiomi Nagasaka, Michio Nakaya. GPRC5B promotes collagen production in myofibroblasts. Biochemical and Biophysical Research Communications. 2021. 561. 180-186
Kotaro Kasai, Yuma Horii, Takanori Hironaka, Kyosuke Mae, Tomoyuki Ueno, Akiomi Nagasaka, Michio Nakaya. Increased Expression of Heparan Sulfate 6-O-Sulfotransferase-2 Promotes Collagen Production in Cardiac Myofibroblasts. BPB Reports. 2021. 4. 3. 85-91

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MISC (2)：

Lectures and oral presentations (4)：

The roles of T-cell death-associated gene 8 (TDAG8), a proton-sensing GPCR, in myocardial infarction
(Translational Research on Metabolic and Inflammatory Diseases and Cancer Date 2019)
プロトン感知性受容体(TDAG8)に着目した心筋梗塞時におけるpH低下の生理的影響の解析
(次世代を担う創薬・医療薬理シンポジウム2017 2017)
心筋梗塞時におけるプロトン感知性受容体TDAG8の役割解析
(第90回日本薬理学会年会 2017)
DNase II欠損マウスを用いたマウスの発生段階におけるアポトーシス細胞の検出
(日本分子生物学会 2008)

Education (2)：

Professional career (1)：

Work history (4)：

Awards (1)：

Association Membership(s) (3)：

THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , THE JAPANESE PHARMACOLOGICAL SOCIETY , THE PHARMACEUTICAL SOCIETY OF JAPAN

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