Suzuki Toshimitsu

スズキトシミツ | Suzuki Toshimitsu

Affiliation and department：
Job title： Lecturer
Homepage URL (1)： http://www.med.nagoya-cu.ac.jp/neurogenet/index.html

Research field (3)： Neuroscience - general , Psychiatry , Genetics

Research keywords (5)： neurodevelopmental disorder , autism spectrum disorder , epilepsy , 疾患責任・関連遺伝子の同定 , 疾患の発症機序の解明

Research theme for competitive and other funds (10)：

2022 - 2025 SCN2A遺伝子変異による社会性行動障害に関わる神経回路の解明
2022 - 2023 SCN2A遺伝子欠損による皮質-側坐核神経回路の異常を介した社会性行動障害の解明
2019 - 2022 EFHC1およびICK遺伝子変異によるてんかんに共通する発症メカニズムの解明
2016 - 2019 EFHC1変異によるてんかん新規発症機序の解明
2012 - 2015 Efhc1コンディショナルノックアウトマウスを用いたてんかん発症機序の解明

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Papers (62)：

Toshimitsu Suzuki, Satoko Hattori, Hiroaki Mizukami, Ryuichi Nakajima, Yurina Hibi, Saho Kato, Mahoro Matsuzaki, Ryu Ikebe, Tsuyoshi Miyakawa, Kazuhiro Yamakawa. Inversed Effects of Nav1.2 Deficiency at Medial Prefrontal Cortex and Ventral Tegmental Area for Prepulse Inhibition in Acoustic Startle Response. Molecular Neurobiology. 2023. 61. 2. 622-634
Remi Stevelink, Ciarán Campbell, Siwei Chen, Bassel Abou-Khalil, Oluyomi M. Adesoji, Zaid Afawi, Elisabetta Amadori, Alison Anderson, Joseph Anderson, Danielle M. Andrade, et al. GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture. Nature Genetics. 2023. 55. 9. 1471-1482
Ludovica Montanucci, David Lewis-Smith, Ryan L. Collins, Lisa-Marie Niestroj, Shridhar Parthasarathy, Julie Xian, Shiva Ganesan, Marie Macnee, Tobias Brünger, Rhys H. Thomas, et al. Genome-wide identification and phenotypic characterization of seizure-associated copy number variations in 741,075 individuals. Nature Communications. 2023. 14. 1. 4392
Linnaeus Bundalian, Yin-Yuan Su, Siwei Chen, Akhil Velluva, Anna Sophia Kirstein, Antje Garten, Saskia Biskup, Florian Battke, Dennis Lal, Henrike O. Heyne, et al. Epilepsies of presumed genetic etiology show enrichment of rare variants that occur in the general population. The American Journal of Human Genetics. 2023. 110. 7. 1110-1122
Tetsushi Yamagata, Ikuo Ogiwara, Tetsuya Tatsukawa, Toshimitsu Suzuki, Yuka Otsuka, Nao Imaeda, Emi Mazaki, Ikuyo Inoue, Natsuko Tokonami, Yurina Hibi, et al. Scn1a-GFP transgenic mouse revealed Nav1.1 expression in neocortical pyramidal tract projection neurons. eLife. 2023. 12. e87495

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MISC (77)：

Suzuki T, Yamakawa K. Identification of responsible genes for temporal lobe epilepsy and investigation of pathological cascade. 2023
Suzuki T, Yamakawa K. Inversed effects of Nav1.2 deficiency at medial prefrontal cortex and ventral tegmental area for prepulse inhibition in acoustic startle response. Molecular neurobiology. 2023
Yamakawa K, Yamagata T, Suzuki T. Pathomechanisms of neurodevelopmental disorders caused by sodium channel gene SCN2A mutations. 第65回日本小児神経学会学術集会 (岡山). 2023
鈴木俊光. 側頭葉てんかん責任遺伝子の同定と発症メカニズムの解明. 2022
Yamakawa K, Suzuki T. Elimination of EFHC1 in brain ventricle ependymal cells reproduces epileptic phenotypes of systemic deficient mouse. 第67回日本人類遺伝学会 (横浜). 2022

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Patents (2)：

てんかんの診断および治療のための組成物ならびに方法
てんかんの診断および治療のための組成物ならびに方法

Professional career (1)：

Ph.D. (Tokyo Medical and Dental University)

Work history (7)：

2021/03 - 現在 Institute of Brain Sciences, Nagoya City University Graduate School of Medical Sciences Department of Neurodevelopmental Disorder Genetics Lecturer
2019/10 - 2021/02 Institute of Brain Sciences, Nagoya City University Graduate School of Medical Sciences Department of Neurodevelopmental Disorder Genetics Assistant Professor
2018/04 - 2019/09 RIKEN Center for Brain Science Lab. for Neurogenetics Research Scientist
2009/04 - 2018/03 RIKEN Brain Science Institute Lab. for Neurogenetics Research Scientist
2006/04 - 2009/03 RIKEN Brain Science Institute Lab. for Neurogenetics Special Postdoctoral Researcher

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