OYAMA Hiroyuki

オオヤマヒロユキ | OYAMA Hiroyuki

Affiliation and department：

Research field (1)： Pharmaceuticals - analytical and physicochemistry

Research keywords (3)：分析化学 , 免疫測定法 , 変異抗体

Research theme for competitive and other funds (11)：

2019 - 2022 Development of new assay system for on-site analysis targeting hallucinogenic compounds in mushrooms
2019 - 2022 Construction of efficient systems for generation of anti-metatypic antibody for high-sensitive detection of small molecules
2019 - 2022 Construction of innovative strategy for selecting improved antibody fragments as the platform generating next-generation diagnostic reagents
2016 - 2019 Efficient generation of high-affinity mutated antibodies based on a single virion direct fluorescence detection of antibody-displaying phage
2016 - 2019 Development of new immunoassay systems for on-site analysis targeting stimulant amines

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Papers (34)：

Takashi Ohgita, Koto Sakai, Nodoka Fukui, Norihiro Namba, Miyu Nakano, Yuki Kiguchi, Izumi Morita, Hiroyuki Oyama, Kouya Yamaki, Kohjiro Nagao, et al. Generation of novel anti-apoE monoclonal antibodies that selectively recognize apoE isoforms. FEBS letters. 2024. 598. 8. 902-914
Takashi Ohgita, Hiroki Kono, Izumi Morita, Hiroyuki Oyama, Toshinori Shimanouchi, Norihiro Kobayashi, Hiroyuki Saito. Intramolecular interaction kinetically regulates fibril formation by human and mouse α-synuclein. Scientific reports. 2023. 13. 1. 10885-10885
Jiulong Su, Bo Zhu, Akihito Inoue, Hiroyuki Oyama, Izumi Morita, Jinhua Dong, Takanobu Yasuda, Yoshiko Sugita-Konishi, Tetsuya Kitaguchi, Norihiro Kobayashi, et al. The Patrol Yeast: A new biosensor armed with antibody-receptor chimera detecting a range of toxic substances associated with food poisoning. Biosensors and Bioelectronics. 2023. 219. 114793-114793
上田宏, 蘇九龍, 朱博, 井上暁人, 大山浩之, 森田いずみ, 董金華, 小西良子, 北口哲也, 小林典裕, et al. 各種食中毒から生活者を守る「パトロール酵母」の開発. 日本生物工学会大会講演要旨集. 2022. 2022年. 135-135
Izumi Morita, Yuki Kiguchi, Saya Nakamura, Ayano Yoshida, Haruna Kubo, Momo Ishida, Hiroyuki Oyama, Norihiro Kobayashi. More than 370-Fold Increase in Antibody Affinity to Estradiol-17β by Exploring Substitutions in the VH-CDR3. Biological & pharmaceutical bulletin. 2022. 45. 7. 851-855

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MISC (6)：

大山浩之, 小林典裕, 加藤芳徳, 丹羽俊文. ハプテンの高感度測定を目的とする抗イディオタイプ抗体scFv-酵素融合体の調製と諸性質. 日本薬学会年会要旨集. 2010. 130年会. 4. 152-152
大山浩之, 加藤芳徳, 小林典裕. K3値が30倍以上増大 "第3世代"変異抗エストラジオール抗体フラグメント. 日本薬学会年会要旨集. 2010. 130年会. 4. 152-152
加藤芳徳, 大山浩之, 小林典裕, 後藤順一. CDR shufflingを活用する高親和力変異抗エストラジオール抗体フラグメントの探索. 日本生物工学会大会講演要旨集. 2007. 平成19年度. 148-148
KATO Yoshinori, OYAMA Hiroyuki, KOBAYASHI Norihiro, GOTO Junichi. Smaller antibody fragments : applications in biomedical analysis. 2007. 36. 2. 125-139
加藤芳徳, 萩原靖恵, 棟大輔, 大山浩之, 小林典裕, 丹羽俊文, 後藤順一. CDRシャッフリングを用いる高性能変異抗エストラジオール抗体の探索. 日本薬学会年会要旨集. 2005. 125年会. 2. 75-75

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Books (1)：

免疫測定法基礎から先端まで
講談社 2014

Education (3)：

2006 - 2009 Kobe Pharmaceutical University
2004 - 2006 Kobe Pharmaceutical University
2000 - 2004 Kobe Pharmaceutical University Faculty of Pharmacy

Professional career (1)：

博士(薬学) (神戸薬科大学)

Work history (4)：

2021/04 - 現在 Kobe Pharmaceutical University
2018/04 - 2021/03 Kobe Pharmaceutical University
2010/04 - 2018/03 Kobe Pharmaceutical University
2009/04 - 2010/03 Kobe Pharmaceutical University

Awards (1)：

2013/08 - 日本臨床化学会奨励賞

Association Membership(s) (5)：

JAPANESE ASSOCIATION OF FORENSIC TOXICOLOGY , Biochemical Assay Society of Japan , JAPAN SOCIETY OF CLINICAL CHEMISTRY , THE JAPAN SOCIETY FOR ANALYTICAL CHEMISTRY , THE PHARMACEUTICAL SOCIETY OF JAPAN

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