SUEMIZU HIROSHI

Research field (1)： Laboratory animal science

Research theme for competitive and other funds (15)：

2019 - 2023 Development of a composite humanized liver chimeric mouse that contributes to pharmacokinetic studies and its application to drug discovery research
2017 - 2019 The functional characterization of cytochrome P450 enzymes from preclinical species
2016 - 2019 Monitoring of transplanted hepatocytes and analysis of immune rejection responses in the hepatocyte chimeric mouse system.
2016 - 2019 Development of human specific hepatotoxicity evaluation method using humanized liver mouse and elucidation of species differences in the pathogenesis of toxicity
2013 - 2015 Basic research for development of artificial liver stem cell

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Papers (197)：

Yoshiyuki Sakai, Tatsuki Fukami, Shinsaku Tokumitsu, Masataka Nakano, Shimon Nakashima, Yuichiro Higuchi, Shotaro Uehara, Nao Yoneda, Hiroshi Suemizu, Miki Nakajima. Impact of miR-222-3p-mediated downregulation of arylacetamide deacetylase on drug hydrolysis and lipid accumulation. Drug Metabolism and Pharmacokinetics. 2024. 101007-101007
Makiko Shimizu, Shotaro Uehara, Katsuhiro Ohyama, Haruka Nishimura, Yoichi Tanaka, Yoshiro Saito, Hiroshi Suemizu, Sayaka Yoshida, Hiroshi Yamazaki. Pharmacokinetic Models Scaled-up from Humanized-liver Mouse Data Can Account for Drug Monitoring Results of Atomoxetine and Its 4-Hydroxylated andN-Demethylated Metabolitesin Pediatric Patients Genotyped for CytochromeP450 2D6. Drug Metabolism and Disposition. 2023. DMD-AR
Shotaro Uehara, Masahiko Yasuda, Yuichiro Higuchi, Nao Yoneda, Kenji Kawai, Masami Suzuki, Hiroshi Yamazaki, Hiroshi Suemizu. SGX523 causes renal toxicity through aldehyde oxidase-mediated less-soluble metabolite formation in chimeric mice with humanized livers. Toxicology letters. 2023. 388. 48-55
内藤駿哉, 竹村晃典, 樋口裕一郎, 上原正太郎, 米田直央, 末水洋志, 伊藤晃成. Hu-liver cellを用いた胆汁酸依存性肝細胞毒性評価凍結初代ヒト肝細胞との比較の観点から. The Journal of Toxicological Sciences. 2023. 48. Suppl. S131-S131
Shotaro Uehara, Yuichiro Higuchi, Nao Yoneda, Ryoji Ito, Takeshi Takahashi, Norie Murayama, Hiroshi Yamazaki, Kazuhiro Murai, Hayato Hikita, Tetsuo Takehara, et al. HepaSH cells: Experimental human hepatocytes with lesser inter-individual variation and more sustainable availability than primary human hepatocytes. Biochemical and biophysical research communications. 2023. 663. 132-141

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MISC (55)：

Kazuhiro Murai, Hayato Hikita, Tasuku Nakabori, Shinji Kuriki, Emi Sometani, Jihyun Sung, Akiyoshi Shimoda, Makoto Fukuoka, Satoshi Shigeno, Akira Nishio, et al. SUPPRESSION OF HSPG2 EXPRESSION INHIBITS HBV ENTRY AND REPLICATION VIA INCREASED cMET EXPRESSION. HEPATOLOGY. 2023. 78. S613-S613
Akiyoshi Shimoda, Hayato Hikita, Kazuhiro Murai, Shinji Kuriki, Emi Sometani, Jihyun Sung, Makoto Fukuoka, Satoshi Shigeno, Akira Nishio, Takahiro Kodama, et al. FDA APPROVED DRUG LIBRARY SCREENING TO IDENTIFY COMPOUNDS THAT REDUCE HBS ANTIGEN. HEPATOLOGY. 2023. 78. S521-S521
遠藤墾, 遠藤墾, 大山夏実, 渡邊恭子, 早川佳那, 早川佳那, 頼添賦, 中野有紀, 藤岡慶史, 末水洋志, et al. マウス顆粒膜細胞の除去による卵巣機能不全モデルマウスの作出. 日本実験動物学会総会講演要旨集(Web). 2023. 70th
早川佳那, 早川佳那, 中野有紀, 遠藤墾, 遠藤墾, 平手良和, 平手良和, 末水洋志, 後藤元人, 高橋利一, et al. TRECK法を用いた子宮内膜上皮置換. 日本実験動物学会総会講演要旨集(Web). 2023. 70th
村井一裕, 疋田隼人, 中堀輔, 栗木真治, 染谷愛美, 成志弦, 下田彬允, 福岡誠, 滋野聡, 西尾啓, et al. HSPG2発現抑制はcMET発現上昇を介してHBVの侵入ならびに複製を阻害する. 肝細胞研究会プログラム・抄録集. 2023. 30th

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Patents (5)：

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