SUEMIZU HIROSHI

Research field (1)： Laboratory animal science

Research theme for competitive and other funds (15)：

2019 - 2023 Development of a composite humanized liver chimeric mouse that contributes to pharmacokinetic studies and its application to drug discovery research
2017 - 2019 The functional characterization of cytochrome P450 enzymes from preclinical species
2016 - 2019 Monitoring of transplanted hepatocytes and analysis of immune rejection responses in the hepatocyte chimeric mouse system.
2016 - 2019 Development of human specific hepatotoxicity evaluation method using humanized liver mouse and elucidation of species differences in the pathogenesis of toxicity
2013 - 2015 Basic research for development of artificial liver stem cell

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Papers (193)：

Yoshiyuki Sakai, Tatsuki Fukami, Shinsaku Tokumitsu, Masataka Nakano, Shimon Nakashima, Yuichiro Higuchi, Shotaro Uehara, Nao Yoneda, Hiroshi Suemizu, Miki Nakajima. Impact of miR-222-3p-mediated downregulation of arylacetamide deacetylase on drug hydrolysis and lipid accumulation. Drug Metabolism and Pharmacokinetics. 2024. 101007-101007
Makiko Shimizu, Shotaro Uehara, Katsuhiro Ohyama, Haruka Nishimura, Yoichi Tanaka, Yoshiro Saito, Hiroshi Suemizu, Sayaka Yoshida, Hiroshi Yamazaki. Pharmacokinetic Models Scaled-up from Humanized-liver Mouse Data Can Account for Drug Monitoring Results of Atomoxetine and Its 4-Hydroxylated andN-Demethylated Metabolitesin Pediatric Patients Genotyped for CytochromeP450 2D6. Drug Metabolism and Disposition. 2023. DMD-AR
Shotaro Uehara, Masahiko Yasuda, Yuichiro Higuchi, Nao Yoneda, Kenji Kawai, Masami Suzuki, Hiroshi Yamazaki, Hiroshi Suemizu. SGX523 causes renal toxicity through aldehyde oxidase-mediated less-soluble metabolite formation in chimeric mice with humanized livers. Toxicology letters. 2023. 388. 48-55
Shotaro Uehara, Yuichiro Higuchi, Nao Yoneda, Ryoji Ito, Takeshi Takahashi, Norie Murayama, Hiroshi Yamazaki, Kazuhiro Murai, Hayato Hikita, Tetsuo Takehara, et al. HepaSH cells: Experimental human hepatocytes with lesser inter-individual variation and more sustainable availability than primary human hepatocytes. Biochemical and biophysical research communications. 2023. 663. 132-141
Yasuhiro Uno, Shotaro Uehara, Genki Ushirozako, Norie Murayama, Hiroshi Suemizu, Hiroshi Yamazaki. Cytochrome P450 1A2 and 2C enzymes autoinduced by omeprazole in dog hepatocytes and human HepaRG and HepaSH cells are involved in omeprazole 5-hydroxylation and sulfoxidation. Xenobiotica. 2023. 53. 6-7. 465-473

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MISC (50)：

村井一裕, 疋田隼人, 中堀輔, 栗木真治, 染谷愛美, 成志弦, 下田彬允, 福岡誠, 滋野聡, 西尾啓, et al. HSPG2発現抑制はcMET発現上昇を介してHBVの侵入ならびに複製を阻害する. 肝細胞研究会プログラム・抄録集. 2023. 30th
金子結, 小牧裕司, 山本真史, 保田昌彦, 末水洋志, 小倉智幸, 高橋利一. Gdf5遺伝子の突然変異による新たな変形性関節症モデルの発見. 日本実験動物学会総会講演要旨集(Web). 2022. 69th
木嶋教行, 兼松大介, 正札智子, 吉岡絵麻, 山本篤世, 半田有佳子, 福角勇人, 勝間亜沙子, 隅田美穂, 森内秀祐, et al. Genetic and molecular properties of long-term proliferating tumorsphere -forming glioma derived cells. 日本脳腫瘍学会プログラム・抄録集. 2021. 39th
Noriyuki Kijima, Yoshikazu Nakajima, Daisuke Kanematsu, Tomoko Shofuda, Yuichiro Higuchi, Hiroshi Suemizu, Kanji Mori, Yoshinori Kodama, Masayuki Mano, Atsushi Sasaki, et al. ESTABLISHMENT OF PATIENT-DERIVED XENOGRAFTS FROM RARE PRIMARY BRAIN TUMORS. NEURO-ONCOLOGY. 2020. 22. 234-234
Noriyuki Kijima, Daisuke Kanematsu, Tomoko Shofuda, Masahiro Nonaka, Ryoichi Iwata, Junya Fukai, Akihiro Inoue, Takashi Sasayama, Naohiro Tsuyuguchi, Toshiyuki Kawashima, et al. CHARACTERIZATION OF PATIENT-DERIVED PRIMARY CELL LINES AND XENOGRAFTS FOR GLIOBLASTOMA. NEURO-ONCOLOGY. 2019. 21. 262-262

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Patents (5)：

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