Rchr
J-GLOBAL ID:201801003013296917   Update date: Jun. 07, 2024

WATANABE Yusuke

WATANABE Yusuke
Affiliation and department:
Research field  (1): Developmental biology
Research keywords  (5): 心臓再生 ,  心臓発生 ,  転写調節 ,  シグナル伝達系 ,  胸部大血管形成
Research theme for competitive and other funds  (37):
  • 2022 - 2025 心室筋細胞特異的な分化運命決定および転写制御機構の解明
  • 2022 - 2025 ALK1シグナルの臓器特異的血管形成における意義と難治性血管疾患の発症メカニズム
  • 2021 - 2024 Downstream genes of signaling pathways implicated in human cardiovascular diseases: in vivo significance and regulatory mechanisms
  • 2020 - 2023 Integrated analysis of pathgenesis of hereditary hemorrhagic telangiectasia
  • 2023 - 心筋特異的な遺伝子発現制御系cTIGREを用いた新規の心筋自己再生誘導因子の探索
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Papers (27):
  • Yusuke Watanabe, Yunce Wang, Yuki Tanaka, Akiyasu Iwase, Teruhisa Kawamura, Yumiko Saga, Kenta Yashiro, Hiroki Kurihara, Osamu Nakagawa. Hey2 enhancer activity defines unipotent progenitors for left ventricular cardiomyocytes in juxta-cardiac field of early mouse embryo. Proceedings of the National Academy of Sciences. 2023. 120. 37
  • Yu Yoshida, Keiko Uchida, Kazuki Kodo, Reina Ishizaki-Asami, Jun Maeda, Yoshinori Katsumata, Shinsuke Yuasa, Keiichi Fukuda, Kenjiro Kosaki, Yusuke Watanabe, et al. A genetic and developmental biological approach for a family with complex congenital heart diseases-evidence of digenic inheritance. Frontiers in cardiovascular medicine. 2023. 10. 1135141-1135141
  • Yukihiro Harada, Toru Tanaka, Yuji Arai, Yoshie Isomoto, Atsushi Nakano, Shu Nakao, Akihiro Urasaki, Yusuke Watanabe, Teruhisa Kawamura, Osamu Nakagawa. ETS-dependent enhancers for endothelial-specific expression of serum/glucocorticoid-regulated kinase 1 during mouse embryo development. Genes to cells : devoted to molecular & cellular mechanisms. 2021. 26. 8. 611-626
  • Yumi Kinugasa-Katayama, Yusuke Watanabe, Takashi Hisamitsu, Yuichiro Arima, Norika M Liu, Ayaka Tomimatsu, Yukihiro Harada, Yuji Arai, Akihiro Urasaki, Teruhisa Kawamura, et al. Tmem100-BAC-EGFP mice to selectively mark and purify embryonic endothelial cells of large caliber arteries in mid-gestational vascular formation. Genesis (New York, N.Y. : 2000). 2021. 59. 4. e23416
  • Daiki Seya, Dai Ihara, Manabu Shirai, Teruhisa Kawamura, Yusuke Watanabe, Osamu Nakagawa. A role of Hey2 transcription factor for right ventricle development through regulation of Tbx2-Mycn pathway during cardiac morphogenesis. Development, growth & differentiation. 2021. 63. 1. 82-92
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MISC (43):
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Lectures and oral presentations  (8):
  • Function and transcriptional regulation of Hey transcription factors during cardiovascular development
    (2019)
  • Significance of Hey1 transcription factor in pharyngeal arch artery formation and regulatory mechanisms of its expression during embryonic development.
    (Weinstein Cardiovascular Development and Regeneration Conference 2018)
  • 咽頭弓に存在する二次心臓領域発生の分子機構
    (第122回日本解剖学会総会全国学術集会 2017)
  • Hrt1/Hey1遺伝子の血管内皮発現制御機構におけるNotchおよびALK1シグナリングによる協調的転写調節メカニズム
    (第24回日本血管生物医学会学術集会 2016)
  • Transcriptional regulation by competitive DNA binding of Islet1 and Nkx2-5 during myocardial differentiation.
    (2015)
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Education (3):
  • 2000 - 2003 広島大学大学院理学研究科生物科学専攻博士課程後期
  • 1998 - 2000 広島大学大学院理学研究科生物科学専攻博士課程前期
  • 1994 - 1998 広島大学理学研究科生物科学専攻
Professional career (1):
  • 博士(理学) (広島大学大学院理学研究科)
Work history (6):
  • 2019/04 - 現在 大阪大学大学院医学系研究科 招へい准教授
  • 2016/10 - 現在 Nara Medical University
  • 2015/04 - 現在 National Cerebral and Cardiovascular Center, Research Institute
  • 2009/06 - 2015/03 東北大学加齢医学研究所
  • 2005/04 - 2009/05 フランス パスツール研究所
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Awards (3):
  • 2017/01 - 国立循環器病研究センター 国循ジョイントリサーチ・プロジェクト賞
  • 2010/01 - 東北大学加齢医学研究所 第16回加齢医学研究所集談会発表コンテスト優秀賞
  • 2005/04 - 笹川日仏財団 パスツール奨学金プログラム
Association Membership(s) (2):
日本発生生物学会 ,  分子生物学会
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