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J-GLOBAL ID:201801003490448184   Update date: Oct. 09, 2024

Shigeru Negi

ネギ シゲル | Shigeru Negi
Affiliation and department:
Research field  (1): Biochemistry
Research keywords  (14): 界面化学 ,  不斉認識 ,  タンパク質のレドックス反応 ,  DNA compaction DNA condensation ,  PARP Family ,  ペプチド科学 ,  機能性タンパク質 ,  分子認識 ,  超分子化学 ,  DNA結合蛋白質 ,  亜鉛フィンガー ,  生物物理化学 ,  タンパク質科学 ,  生体機能関連化学
Research theme for competitive and other funds  (10):
  • 2017 - 2020 Study on the role of endogenous CO in the circadian clock system
  • 2014 - 2017 Investigation of new zinc finger protein function as a redox sensor for reactive oxygen in the cells
  • 2012 - 2015 Specific DNA Recognition by Fluctuation of Zinc Finger Protein and Development for Smart Transcription Factor
  • 2011 - 2013 Structural and functional analysis of zinc finger protein in metal binding and redox reaction
  • 2010 - 2012 Creation of First Enzyme-Type Zinc Finger Protein PossessingCatalytic Function
Show all
Papers (45):
  • Qiyue Mao, Xuansu Zhao, Akiko Kiriyama, Shigeru Negi, Yasutaka Fukuda, Hideki Yoshioka, Akira T. Kawaguchi, Roberto Motterlini, Roberta Foresti, Hiroaki Kitagishi. A synthetic porphyrin as an effective dual antidote against carbon monoxide and cyanide poisoning. Proceedings of the National Academy of Sciences (PNAS). 2023. 120. 9 2209924120. 1-10
  • Shigeru Negi, Miki Imanishi, Mami Hamori, Yuka Kawahara-Nakagawa, Wataru Nomura, Kanae Kishi, Nobuhito Shibata, Yukio Sugiura. The Past, Present, and Future of Artificial Zinc Finger Proteins: Design Strategies and Chemical and Biological Applications. JBIC Journal of Biological Inorganic Chemistry Just accepted. 2023. 28. 3. 249-261
  • Shigeru NEGI, Mami HAMORI, Hiroaki KITAGISHI, Yukio SUGIURA. Creation and Biological Application of Intelligent Zinc Finger Proteins. The Harris science review of Doshisha University. 2023. 63. 4. 55-62
  • Shigeru Negi, Mami Hamori, Yoshiyasu Kubo, Hiroaki Kitagishi, Koji Kano. Monolayer formation and chiral recognition of binaphthyl amphiphiles at the air-water interface. Bulletin of the Chemical Society of Japan. 2023. 96. 48-56
  • Shigeru Negi, Mami Hamori, Yuka Kawahara-Nakagawa, Masato Mashimo, Miki Imanishi, Nozomi Kuki, Yuri Kawahito, Takayuki Manabe, Nobuyuki Kawamura, Jyunichiro Yasukawa, et al. Effect of charged-cluster distribution of the ZIF268 zinc finger surface on cell membrane permeability. Chemistry Letters. 2022. 52. 2. 75-78
more...
MISC (141):
  • 川人友里, 岸果苗, 中川由佳, 根木滋. Kinetic approach to position-dependent Cys oxidation of Met by H2O2. 日本薬学会年会要旨集(Web). 2024. 144th
  • 村上花楓, 小松由佳, 中川由佳, 羽森真美, 根木滋. GSHの構造機能相関の再考:ルイス塩基部位と金属イオンの相互作用が還元反応に及ぼす影響. 日本蛋白質科学会年会プログラム・要旨集. 2023. 23rd (CD-ROM)
  • 根木滋, 細井咲良, 古澤宏幸, 中川由佳, 間下雅士. 水晶振動子マイクロバランス(QCM)法によるPARP-1が関与するDNA修復機構の定量的評価. 日本蛋白質科学会年会プログラム・要旨集. 2023. 23rd (CD-ROM)
  • 横関麻佑, 川人友里, 岸果苗, 中川由佳, 羽森真美, 根木滋. Investigation of the importance of the number of amino acids between Cys residues in redox couples in vivo using zinc finger protein as a model. 日本薬学会年会要旨集(Web). 2023. 143rd
  • 川人友里, 岸果苗, 横関麻佑, 中川由佳, 羽森真美, 根木滋. Kinetic Approach to the Mechanism of Zinc Finger Oxidation by Hydrogen Peroxide. 日本薬学会年会要旨集(Web). 2023. 143rd
more...
Lectures and oral presentations  (13):
  • Polyion complexation between oligoarginine and genomic DNA
    (The 24th peptide forum in Kyoto 2018 2018)
  • Important role of two-dimesional cationic cluster in cellular uptake
    (2018)
  • Coexistence of a metal ion effect on reduction reactions by mono thiol reagents with an oxidized GAGA zinc finger peotein
    (10th International peptide symposium 2018)
  • Reversible control of DNA binding of GAL4 transcription factor by a cyclodextrin-porphyrin supramolecular complex
    (10th International peptide symposium 2018)
  • Polyion complexation between oligoarginine and genomic DNA
    (10th International peptide symposium 2018)
more...
Professional career (1):
  • 博士(工学) (同志社大学)
Work history (1):
  • - 現在 Doshisha Women's College of Liberal Arts Faculty of Pharmaceutical Sciences, Department of Clinical Pharmacy
Association Membership(s) (5):
THE BIOPHYSICAL SOCIETY OF JAPAN ,  The Society of Cyclodextrins , Japan ,  THE JAPANESE BIOCHEMICAL SOCIETY ,  THE PHARMACEUTICAL SOCIETY OF JAPAN ,  THE CHEMICAL SOCIETY OF JAPAN
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