Research keywords (14):
界面化学
, 不斉認識
, タンパク質のレドックス反応
, DNA compaction DNA condensation
, PARP Family
, ペプチド科学
, 機能性タンパク質
, 分子認識
, 超分子化学
, DNA結合蛋白質
, 亜鉛フィンガー
, 生物物理化学
, タンパク質科学
, 生体機能関連化学
Research theme for competitive and other funds (10):
2017 - 2020 Study on the role of endogenous CO in the circadian clock system
2014 - 2017 Investigation of new zinc finger protein function as a redox sensor for reactive oxygen in the cells
2012 - 2015 Specific DNA Recognition by Fluctuation of Zinc Finger Protein and Development for Smart Transcription Factor
2011 - 2013 Structural and functional analysis of zinc finger protein in metal binding and redox reaction
2010 - 2012 Creation of First Enzyme-Type Zinc Finger Protein PossessingCatalytic Function
2009 - 2011 Capture of diatomic molecules by supramolecular heme protein models and application to development to medicinal chemistry
2008 - 2010 Creation and Pharmaceutical Development of Intelligent Zinc Fingers Based on Genomic Chemistry
2008 - 2010 Creation of artificial peptidase based on zinc finger framework
2006 - 2007 触媒作用を有する人工金属フィンガータンパク質の創製
2005 - 2007 Creation of New Functional Artificial Metallofingers : Construction of Library and Development to Gene Regulation
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Papers (45):
Qiyue Mao, Xuansu Zhao, Akiko Kiriyama, Shigeru Negi, Yasutaka Fukuda, Hideki Yoshioka, Akira T. Kawaguchi, Roberto Motterlini, Roberta Foresti, Hiroaki Kitagishi. A synthetic porphyrin as an effective dual antidote against carbon monoxide and cyanide poisoning. Proceedings of the National Academy of Sciences (PNAS). 2023. 120. 9 2209924120. 1-10
Shigeru Negi, Miki Imanishi, Mami Hamori, Yuka Kawahara-Nakagawa, Wataru Nomura, Kanae Kishi, Nobuhito Shibata, Yukio Sugiura. The Past, Present, and Future of Artificial Zinc Finger Proteins: Design Strategies and Chemical and Biological Applications. JBIC Journal of Biological Inorganic Chemistry Just accepted. 2023. 28. 3. 249-261
Shigeru NEGI, Mami HAMORI, Hiroaki KITAGISHI, Yukio SUGIURA. Creation and Biological Application of Intelligent Zinc Finger Proteins. The Harris science review of Doshisha University. 2023. 63. 4. 55-62
Shigeru Negi, Mami Hamori, Yoshiyasu Kubo, Hiroaki Kitagishi, Koji Kano. Monolayer formation and chiral recognition of binaphthyl amphiphiles at the air-water interface. Bulletin of the Chemical Society of Japan. 2023. 96. 48-56
Shigeru Negi, Mami Hamori, Yuka Kawahara-Nakagawa, Masato Mashimo, Miki Imanishi, Nozomi Kuki, Yuri Kawahito, Takayuki Manabe, Nobuyuki Kawamura, Jyunichiro Yasukawa, et al. Effect of charged-cluster distribution of the ZIF268 zinc finger surface on cell membrane permeability. Chemistry Letters. 2022. 52. 2. 75-78
横関麻佑, 川人友里, 岸果苗, 中川由佳, 羽森真美, 根木滋. Investigation of the importance of the number of amino acids between Cys residues in redox couples in vivo using zinc finger protein as a model. 日本薬学会年会要旨集(Web). 2023. 143rd
川人友里, 岸果苗, 横関麻佑, 中川由佳, 羽森真美, 根木滋. Kinetic Approach to the Mechanism of Zinc Finger Oxidation by Hydrogen Peroxide. 日本薬学会年会要旨集(Web). 2023. 143rd
Polyion complexation between oligoarginine and genomic DNA
(The 24th peptide forum in Kyoto 2018 2018)
Important role of two-dimesional cationic cluster in cellular uptake
(2018)
Coexistence of a metal ion effect on reduction reactions by mono thiol reagents with an oxidized GAGA zinc finger peotein
(10th International peptide symposium 2018)
Reversible control of DNA binding of GAL4 transcription factor by a cyclodextrin-porphyrin supramolecular complex
(10th International peptide symposium 2018)
Polyion complexation between oligoarginine and genomic DNA
(10th International peptide symposium 2018)
- 現在 Doshisha Women's College of Liberal Arts Faculty of Pharmaceutical Sciences, Department of Clinical Pharmacy
Association Membership(s) (5):
THE BIOPHYSICAL SOCIETY OF JAPAN
, The Society of Cyclodextrins , Japan
, THE JAPANESE BIOCHEMICAL SOCIETY
, THE PHARMACEUTICAL SOCIETY OF JAPAN
, THE CHEMICAL SOCIETY OF JAPAN