
	Chemical structure search How to Search	Import MOLfile format is only available (V3000 format is not available) Exact match Substructure search Superstructure search Substructure or superstructure search Similarity search

Co-authoring Researcher

Co-inventing Researcher

Researcher similar to the Researcher

Article similar to the Researcher

Patent similar to the Researcher

Research Project similar to the Researcher

Article(J-GLOBAL estimation)

Patent(J-GLOBAL estimation)

Rchr

J-GLOBAL ID：201801004259394639 Update date: Jan. 27, 2025

Takao Hashiguchi

ハシグチタカオ | Takao Hashiguchi

Affiliation and department：

Research field (3)： Virology , Structural biochemistry , Pharmaceuticals - chemistry and drug development

Research keywords (8)：膜融合 , 創薬 , 抗体 , 受容体 , 糖蛋白質 , 感染症 , 構造生物学 , ウイルス学

Research theme for competitive and other funds (17)：

2024 - 2027 Advancement of Structure-Based B-cell Repertoire Mining Technology and Its Application to Antibody Miniaturization
2023 - 2026 パラミクソウイルスの糖鎖受容体認識機構と宿主域・トロピズムの解明
2023 - 2026 Study of brain organoids and mouse models for the therapeutic application of paramyxovirus central nervous system infection
2023 - 2026 出血熱アレナウイルス感染症の予防法及び治療法開発のための分子基盤研究
2021 - 2025 Transporting drugs across the blood-brain barrier through information technology

Show all

Papers (74)：

Jiei Sasaki, Akihiko Sato, Michihito Sasaki, Iori Okabe, Kota Kodama, Satoko Otsuguro, Kosuke Yasuda, Hirotatsu Kojima, Yasuko Orba, Hirofumi Sawa, et al. X-206 exhibits broad-spectrum anti-β-coronavirus activity, covering SARS-CoV-2 variants and drug-resistant isolates. Antiviral research. 2024. 106039-106039
Hisano Yajima, Yuki Anraku, Yu Kaku, Kanako Terakado Kimura, Arnon Plianchaisuk, Kaho Okumura, Yoshiko Nakada-Nakura, Yusuke Atarashi, Takuya Hemmi, Daisuke Kuroda, et al. Structural basis for receptor-binding domain mobility of the spike in SARS-CoV-2 BA.2.86 and JN.1. Nature Communications. 2024. 15. 1
Hisano Yajima, Tomo Nomai, Kaho Okumura, Katsumi Maenaka, Jumpei Ito, Takao Hashiguchi, Kei Sato. Molecular and structural insights into SARS-CoV-2 evolution: from BA.2 to XBB subvariants. mBio. 2024. e0322023
Hideo Fukuhara, Kohei Yumoto, Miyuki Sako, Mizuho Kajikawa, Toyoyuki Ose, Mihiro Kawamura, Mei Yoda, Surui Chen, Yuri Ito, Shin Takeda, et al. Glycan-shielded homodimer structure and dynamical features of the canine distemper virus hemagglutinin relevant for viral entry and efficient vaccination. eLife. 2024. 12
Takao Hashiguchi, Hisano Yajima, Yuki Anraku, Yu Kaku, Kanako Kimura, Arnon Plianchaisuk, Kaho Okumura, Yoshiko Nakada-Nakura, Shunsuke Kita, Jiei Sasaki, et al. A triggering structure of SARS-CoV-2 BA.2.86 spike upon ACE2 binding for receptor-binding domain up. 2024

MISC (41)：

中川優奈, 川口祥正, 広瀬久昭, 橋口隆生, 二木史朗. Cell-Specific and Efficient Delivery By SARS-CoV-2 Spike Protein-Loaded Extracellular Vesicles. 日本薬学会年会要旨集(Web). 2024. 144th
木村香菜子, 橋口隆生. Structural Virology for understanding viruses. 実験医学. 2024. 42. 8
佐藤裕真, 橋口隆生. Mechanisms underlying central nervous system infection caused by measles virus. 医学のあゆみ. 2024. 288. 12
小澤龍彦, 小澤龍彦, 池田幸樹, CHEN Liuan, 鈴木理滋, 星野温, 野口映, 喜多俊介, 安楽佑樹, 五十嵐笑子, et al. In silicoで改変したUT28KはSARS-CoV-2オミクロンBA.1に対して中和活性を回復した. 日本抗体学会学術大会プログラム・抄録集(Web). 2023. 2nd
橋口隆生. Structural Basis of Receptor Recognition and Escape from Neutralizing Antibodies by SARS-CoV-2 variants. 量子ビームサイエンスフェスタ(Web). 2023. 2022

Books (16)：

Lectures and oral presentations (30)：

Inhibitory mechanisms of virus cellular entry: structure-guided drug development
(日本細菌学雑誌(Web) 2020)
Structure-guided and computer-aided drug development to ameliorate persistent measles virus infection in the central nervous system
(Japan-UK Workshop on Infectious Disease Research(AMED-英国大使館主催) 2019)
小児ウイルス感染症とその感染阻害機構
(第5回外力支援型バイオアッセイ技術コンソーシアム技術セミナー・技術交流会(産総研) 2019)
構造情報を活用したおたふくかぜ・はしかウイルス感染阻害メカニズムの解明と創薬展開
(日本生化学会大会(Web) 2019)
ウイルスの細胞侵入機構を標的とした創薬モダリティ
(構造活性フォーラム講演要旨集 2019)

Education (3)：

Professional career (1)：

Work history (7)：

2022/04 - 現在 Kyoto University Institute for Frontier Life and Medical Sciences Professor
2020/09 - 2022/03 Kyoto University Institute for Frontier Life and Medical Sciences Professor
2016/04 - 2020/08 Kyushu University Department of Virology, Faculty of medicine Associate professor
2013/04 - 2016/03 Kyushu University Department of Virology, Faculty of medicine Assistant professor
2012/04 - 2013/03 The Scripps Research Institute Dept of Immunology and Microbiology Research associate

Show all

Awards (3)：

Association Membership(s) (2)：

PROTEIN SCIENCE SOCIETY OF JAPAN , THE JAPANESE SOCIETY FOR VIROLOGY

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.


	Free word	※Add the following synonyms, you can increase the number of hits.




		～