Takao Hashiguchi

ハシグチタカオ | Takao Hashiguchi

Affiliation and department：

Research field (3)： Virology , Structural biochemistry , Pharmaceuticals - chemistry and drug development

Research keywords (8)：膜融合 , 創薬 , 抗体 , 受容体 , 糖蛋白質 , 感染症 , 構造生物学 , ウイルス学

Research theme for competitive and other funds (16)：

2023 - 2026 パラミクソウイルスの糖鎖受容体認識機構と宿主域・トロピズムの解明
2023 - 2026 Study of brain organoids and mouse models for the therapeutic application of paramyxovirus central nervous system infection
2023 - 2026 出血熱アレナウイルス感染症の予防法及び治療法開発のための分子基盤研究
2021 - 2025 Transporting drugs across the blood-brain barrier through information technology
2020 - 2024 情報科学的アプローチを活用した精密な機能性分子設計システムの構築

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Papers (71)：

Hideo Fukuhara, Kohei Yumoto, Miyuki Sako, Mizuho Kajikawa, Toyoyuki Ose, Mihiro Kawamura, Mei Yoda, Surui Chen, Yuri Ito, Shin Takeda, et al. Glycan-shielded homodimer structure and dynamical features of the canine distemper virus hemagglutinin relevant for viral entry and efficient vaccination. eLife. 2024. 12
Takao Hashiguchi, Hisano Yajima, Yuki Anraku, Yu Kaku, Kanako Kimura, Arnon Plianchaisuk, Kaho Okumura, Yoshiko Nakada-Nakura, Shunsuke Kita, Jiei Sasaki, et al. A triggering structure of SARS-CoV-2 BA.2.86 spike upon ACE2 binding for receptor-binding domain up. 2024
Rimpa Paul, Keisuke Kasahara, Jiei Sasaki, Jorge Fernández Pérez, Ryo Matsunaga, Takao Hashiguchi, Daisuke Kuroda, Kouhei Tsumoto. Unveiling the affinity-stability relationship in anti-measles virus antibodies: a computational approach for hotspots prediction. Frontiers in Molecular Biosciences. 2024. 10
Tomokazu Tamura, Takashi Irie, Sayaka Deguchi, Hisano Yajima, Masumi Tsuda, Hesham Nasser, Keita Mizuma, Arnon Plianchaisuk, Saori Suzuki, Keiya Uriu, et al. Virological characteristics of the SARS-CoV-2 Omicron XBB.1.5 variant. Nature communications. 2024. 15. 1. 1176-1176
Tomoyuki Homma, Noriyo Nagata, Masayuki Hashimoto, Naoko Iwata-Yoshikawa, Naomi M Seki, Nozomi Shiwa-Sudo, Akira Ainai, Keiji Dohi, Eiji Nikaido, Akiko Mukai, et al. Author Correction: Immune response and protective efficacy of the SARS-CoV-2 recombinant spike protein vaccine S-268019-b in mice. Scientific reports. 2024. 14. 1. 2599-2599

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MISC (37)：

佐藤裕真, 橋口隆生. Mechanisms underlying central nervous system infection caused by measles virus. 医学のあゆみ. 2024. 288. 12
橋口隆生. Structural Basis of Receptor Recognition and Escape from Neutralizing Antibodies by SARS-CoV-2 variants. 量子ビームサイエンスフェスタ(Web). 2023. 2022
山本旭麻, 東浦彰史, 下岡清美, 河野洋平, 喜多俊介, 安楽佑樹, 橋口隆生, 前仲勝実, 保田朋波流, 坂口剛正. Neutralization mechanism revealed by structural analysis of SARS CoV-2 spike protein complexed with antibodies. 日本ウイルス学会学術集会プログラム・予稿集(Web). 2023. 70th
矢島久乃, 安楽佑樹, 喜多俊介, 佐々木慈英, 木村(寺角)香菜子, 前仲勝実, 佐藤佳, 福原崇介, 橋口隆生. Cryo-EM structure of SARS-CoV-2 XBB.1.5 spike protein and its ACE2 receptor recognition mechanism and structural comparison with XBB.1. 日本ウイルス学会学術集会プログラム・予稿集(Web). 2023. 70th
安楽佑樹, 喜多俊介, 矢島久乃, 佐藤佳, 橋口隆生, 前仲勝実. Structural analysis of SARS-CoV-2 XBB.1 spike protein and ACE2 complex. 日本ウイルス学会学術集会プログラム・予稿集(Web). 2023. 70th

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Books (16)：

Viral Biophysics: Contributions to Drug Modalities
2021
Mumps virus receptors
2019
最先端微生物学研究に基づいた疾病対策の試み X線結晶構造に基づくパラミクソウイルスの細胞侵入阻害機構と創薬への展開
獣医畜産新報 2018
RNAウイルスの細胞侵入機構の構造基盤の解明
感染・炎症・免疫 2017
マイナス鎖RNAウイルスの細胞侵入と抗体による中和の研究
ウイルス 2017

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Lectures and oral presentations (30)：

Inhibitory mechanisms of virus cellular entry: structure-guided drug development
(日本細菌学雑誌(Web) 2020)
Structure-guided and computer-aided drug development to ameliorate persistent measles virus infection in the central nervous system
(Japan-UK Workshop on Infectious Disease Research(AMED-英国大使館主催) 2019)
小児ウイルス感染症とその感染阻害機構
(第5回外力支援型バイオアッセイ技術コンソーシアム技術セミナー・技術交流会(産総研) 2019)
構造情報を活用したおたふくかぜ・はしかウイルス感染阻害メカニズムの解明と創薬展開
(日本生化学会大会(Web) 2019)
ウイルスの細胞侵入機構を標的とした創薬モダリティ
(構造活性フォーラム講演要旨集 2019)

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Education (3)：

2005 - 2008 Kyushu University Faculty of medicine Department of Virology
2003 - 2005 Kyushu University Faculty of medicine Medical science
1999 - 2003 Kyushu University Department of science Faculty of chemistry

Professional career (1)：

博士(医学) (九州大学)

Work history (7)：

2022/04 - 現在 Kyoto University Institute for Frontier Life and Medical Sciences Professor
2020/09 - 2022/03 Kyoto University Institute for Frontier Life and Medical Sciences Professor
2016/04 - 2020/08 Kyushu University Department of Virology, Faculty of medicine Associate professor
2013/04 - 2016/03 Kyushu University Department of Virology, Faculty of medicine Assistant professor
2012/04 - 2013/03 The Scripps Research Institute Dept of Immunology and Microbiology Research associate

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Awards (3)：

2017/12 - 第1回日本医療研究開発大賞 AMED理事長賞
2016/10 - 平成28年度日本ウイルス学会杉浦奨励賞
2016/04 - 平成28年度文部科学大臣表彰若手科学者賞

Association Membership(s) (2)：

PROTEIN SCIENCE SOCIETY OF JAPAN , THE JAPANESE SOCIETY FOR VIROLOGY

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