Rchr
J-GLOBAL ID：201801004282493997
Update date: Mar. 06, 2024
AKINORI KANAI
カナイ アキノリ | AKINORI KANAI
Affiliation and department：
Job title：
Project Associate Professor
Research field (1)：
Molecular biology
Research theme for competitive and other funds (14)：
- 2022 - 2027 Development of novel therapies for ENL-mutated Wilms tumor
- 2022 - 2027 幹細胞の可視化によるがん化プロセス解析マウスモデルを用いた放射線発がん機構の解明
- 2022 - 2025 Mechanisms of AF10-rearranged leukemia
- 2021 - 2024 Samd9/9L症候群とIFNシグナルから迫るMDS発症の分子メカニズム
- 2021 - 2024 A novel radioprotective mechanism of sodium orthovanadate and its application to radiotherapy
- 2021 - 2024 Trim43が放射線による受精卵発生停止に与える分子機構の解明
- 2020 - 2023 新規エピゲノム制御を介した造血器腫瘍の病態促進機構の解明
- 2018 - 2021 Abnormal endosomal traffic induced by Samd9/9L causing myelodysplastic syndromes and inherited bone marrow failure
- 2018 - 2021 The effects of ionizing radiation on early development stage of the fertilized egg
- 2017 - 2020 Context-dependent regulation of histone methylation in a subset of hematologic malignancies
- 2015 - 2018 Elucidation of molecular mechanism through which MDS develops
- 2015 - 2017 Analysis of radiation induced mutation patterns and frequencies with whole genome sequencing
- 2013 - 2015 Analysis of radiation induced mutations using next generation sequencer
- 2012 - 2015 DNA demethylation facilitates globin translation in myelodysplastic syndrome
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Papers (80)：
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Muran Xiao, Shinji Kondo, Masaki Nomura, Shinichiro Kato, Koutarou Nishimura, Weijia Zang, Yifan Zhang, Tomohiro Akashi, Aaron Viny, Tsukasa Shigehiro, et al. BRD9 determines the cell fate of hematopoietic stem cells by regulating chromatin state. Nature communications. 2023. 14. 1. 8372-8372
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Yasuhiko Haga, Yoshitaka Sakamoto, Keiko Kajiya, Hitomi Kawai, Miho Oka, Noriko Motoi, Masayuki Shirasawa, Masaya Yotsukura, Shun-Ichi Watanabe, Miyuki Arai, et al. Whole-genome sequencing reveals the molecular implications of the stepwise progression of lung adenocarcinoma. Nature communications. 2023. 14. 1. 8375-8375
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Kentaro Mizuhara, Yuji Shimura, Taku Tsukamoto, Akinori Kanai, Saeko Kuwahara-Ota, Junko Yamaguchi, Ayako Muramatsu, Haruya Okamoto, Yoko Taminishi-Katsuragawa, Yuka Kawaji-Kanayama, et al. Tumour-derived exosomes promote the induction of monocytic myeloid-derived suppressor cells from peripheral blood mononuclear cells by delivering miR-106a-5p and miR-146a-5p in multiple myeloma. British journal of haematology. 2023
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Takako Yokomizo-Nakano, Ai Hamashima, Sho Kubota, Jie Bai, Supannika Sorin, Yuqi Sun, Kenta Kikuchi, Mihoko Iimori, Mariko Morii, Akinori Kanai, et al. Exposure to microbial products followed by loss of Tet2 promotes myelodysplastic syndrome via remodeling HSCs. The Journal of experimental medicine. 2023. 220. 7
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水原 健太郎, 志村 勇司, 塚本 拓, 金井 昭教, 太田 沙絵子, 山口 順子, 村松 彩子, 岡本 明也, 民西 葉子, 金山 悠加, et al. 多発性骨髄腫でのM-MDSC誘導における腫瘍由来エキソソームを介したmiR-106a-5pとmiR-146a-5pの役割(The functional roles of miR-106a-5p and miR-146a-5p transferred by tumor-derived exosome in the induction of M-MDSCs in multiple myeloma). International Journal of Myeloma. 2023. 13. 3. 88-88
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MISC (52)：
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神力 悟, 平山 真弓, 金井 昭教, 長町 安希子, 稲葉 俊哉, 松井 啓隆. DDX41の機能抑制による翻訳変化とR-loopの蓄積. 日本癌学会総会記事. 2021. 80回. [P14-2]
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長町 安希子, 松井 啓隆, 金井 昭教, 神力 悟, 稲葉 俊哉. SAMD9/9L症候群の7q-/MDS多発におけるIFNγシグナルの関与. 日本癌学会総会記事. 2021. 80回. [J14-2]
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長町 安希子, 松井 啓隆, 金井 昭教, 神力 悟, 稲葉 俊哉. Involvement of IFNγ in the development of 7q-/MDS in patients with SAMD9/9L syndromes(和訳中). 日本血液学会学術集会. 2021. 83回. OS3-5
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長町 安希子, 松井 啓隆, 金井 昭教, 神力 悟, 稲葉 俊哉. SAMD9/9L症候群の7q-/MDS多発におけるIFNγシグナルの関与. 日本癌学会総会記事. 2021. 80回. [J14-2]
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神力 悟, 平山 真弓, 金井 昭教, 長町 安希子, 稲葉 俊哉, 松井 啓隆. DDX41の機能抑制による翻訳変化とR-loopの蓄積. 日本癌学会総会記事. 2021. 80回. [P14-2]
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Professional career (1)：
- 博士(生命科学) (東京大学大学院新領域創成科学研究科)
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