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J-GLOBAL ID：201801004633890890 Update date: Dec. 30, 2024

Karuo Yukiko

カルオユキコ | Karuo Yukiko

Affiliation and department：
Job title： Lecturer

Research field (1)： Pharmaceuticals - chemistry and drug development

Research theme for competitive and other funds (7)：

2023 - 2026 従来法では不可能なアルコール中で求核的フッ素化できる環境調和型フッ素化法の創出
2023 - 2026 従来法では不可能なアルコール中で求核的フッ素化できる環境調和型フッ素化法の創出
2022 - 2025 多剤耐性菌のMATE型多剤排出ポンプを選択的に阻害するリード化合物の創出
2019 - 2023 Development of small molecule fluorescent compounds and elaboration of fluorescent probe for periodontal bacteria
2022 - 2023 特異な反応性を有するピリジニウムフルオリドの求核的18F-フッ素化試薬への展開

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Papers (31)：

Kazuyuki Sato, Kazuki Nakano, Takahiro Ueda, Yukine Kitamura, Yuna Tanaka, Yukiko Karuo, Atsushi Tarui, Kentaro Kawai, Masaaki Omote. Construction of new quaternary carbon center of fluorinated isoxazolines at C5 position via C-F bond cleavage. Journal of Fluorine Chemistry. 2024. 279
Kentaro Kawai, Yukiko Karuo, Atsushi Tarui, Kazuyuki Sato, Makoto Kataoka, Masaaki Omote. Development of Drug Discovery Platforms Using Artificial Intelligence and Cheminformatics. Chemical and Pharmaceutical Bulletin. 2024. 72. 9. 794-799
Atsushi Tarui, Hiroshi Shimomura, Yohei Yasuno, Yukiko Karuo, Kazuyuki Sato, Kentaro Kawai, Masaaki Omote. Decarboxylative Aldol Reaction of α,α-Difluoro-β-keto Esters: Easy Access to Difluoroenolate. ACS Omega. 2024. 9. 24. 26275-26284
Kazuyuki Sato, Satoki Teranishi, Atsushi Sakaue, Yukiko Karuo, Atsushi Tarui, Kentaro Kawai, Hiroyuki Takeda, Tatsuo Kinashi, Masaaki Omote. Rhodium-catalyzed homo-coupling reaction of aryl Grignard reagents and its application for the synthesis of an integrin inhibitor. Beilstein journal of organic chemistry. 2024. 20. 1341-1347
Kazuyuki Sato, Tomohiro Kuroki, Haruka Minami, Azusa Sato, Yukiko Karuo, Atsushi Tarui, Kentaro Kawai, Masaaki Omote. Electrophilic aromatic substitution using fluorinated isoxazolines at the C5 position via C-F bond cleavage. RSC Advances. 2024. 14. 53. 39543-39549

Books (1)：

Lectures and oral presentations (92)：

薬物動態学的増強因子としての新規ベンジルオキシフェニルイミダゾール誘導体
(第51回構造活性相関シンポジウム)
Exploration and Synthesis of Inhibitors Targeting the Bacterial Multidrug Efflux Pump MATE-type transporter
(第40回メディシナルケミストリーシンポジウム)
Development of a model for predicting binding poses of RORγ inhibitors using machinelearning with ligand coordinate profile
(CBI学会2023年大会)
細菌抗菌薬排出機構MATE型輸送体の新規阻害剤の探索合成と活性評価
(第46回フッ素化学討論会)
細菌薬剤排出トランスポーターMATEを標的とした阻害剤の開発
(2023年度FMODD夏の学校)

Education (2)：

Professional career (1)：

Committee career (1)：

Awards (3)：

Association Membership(s) (3)：

日本フッ素化学会 , 有機合成化学協会 , 日本薬学会

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