Katsuto Tamai

Affiliation and department：

Research field (1)： Dermatology

Research keywords (3)：再生医学 , 遺伝子治療学 , 皮膚科学

Research theme for competitive and other funds (36)：

2022 - 2025 ヒト子宮着床能前方視的評価メカニズム解明のための月経による内膜再生機構の基礎検討
2022 - 2025 HMGB1ペプチドを用いた末梢血間葉系幹細胞動員による腎線維化の抑制
2022 - 2025 内因性危険シグナルHMGB1誘導性組織再生における骨髄間葉系幹細胞活性化機構解明
2021 - 2024 強皮症モデルマウスにおけるHMGB1による骨髄由来間葉系幹細胞の誘導
2021 - 2024 Regeneration-inducing medicine for Bronchopulmonary displasia

2019 - 2022 Study for developmental origin of mesenchymal blood cells and their regenerative activity in epidermolysis bullosa

2018 - 2021 Development of a novel method for Induction of Fetal Immunological Tolerance using Maternal microchymerism

2016 - 2019 Investigation of in vivo function of mesenchymal blood cells on maintenance of cutaneous homeostasis and application for therapeutics

2015 - 2018 In utero Immune tolerance induction for Severe Congenital skin diseases

2013 - 2016 Study for mechanism of maintaining cutaneous homeostasis by HMGB1-induced mesenchymal stem cell mobilization from bone marrow, and application for treating intractable skin diseases.

2014 - 2015 Development of novel therapeutic strategy for skin diseases by utilizing anti-inflammatory activity of circulating mesenchymal stem cells

2013 - 2014 胎児期免疫寛容誘導による皮膚難病細胞移植治療への応用

2012 - 2012 Development of activator for skin function using bone marrow mesenchymal stem cell mobilizer

2010 - 2012 Elucidation of mesenchymal to epithelial transition mechanism of bone marrow mesenchymal stem cells and application to regenerative medicine.

2009 - 2011 Development of the new cell-free device for sever heart failure by restructuring of artificial stem cell niche using extracellular matrixes and stem cell recruitment/differentiation factors

2009 - 2009 骨髄間葉系および上皮系前駆細胞の高効率回収法開発と難治性皮膚疾患治療への応用

2007 - 2009 Basic research for inducing epithelial regeneration by bone marrow-derived epithelial cells

2007 - 2007 間葉系幹細胞動員因子を利用した非瘢痕性創傷治癒誘導研究

2006 - 2006 染色体部位特異的遺伝子導入法開発と表皮水疱症遺伝子治療への応用

2004 - 2006 Development of less-invasive in vivo gene delivery system and application to gene therapy for dystrophic epidermolysis bullosa

2005 - 2005 骨髄由来末梢血造表皮幹細胞を利用した遺伝子治療法開発

2004 - 2004 骨髄間葉系幹細胞の表皮幹細胞への形質転換と臨床応用に関する研究

2003 - 2003 表皮性POU転写因子Skn-1nを標的とした尋常性乾癬治療法開発のための基礎研究

2002 - 2003 Development of gene therapy for dystrophic epidemolysis bullosa with artificial adhension molecule

2001 - 2003 Molecular mechanism of scarless wound healing its application for therapy of epidermolysis bullosa

2002 - 2002 ES細胞由来表皮ケラチノサイトを用いた表皮性POU転写因子Skn-1nの機能解析

2001 - 2001 表皮再生医療の基礎研究:線維芽細胞から表皮細胞への形質転換の試み

1999 - 2001 Development of a new photo-aging model system: A quick evaluation method for photo-damage utilizing elastin-promoter/green fluorescence protein (GFP) reporter gene transfected dermal fibroblasts

1999 - 2001 ホルモン遺伝子を表皮細胞に導入することによるホルモンの全身への供給

1998 - 2001 The role of POU domain transcription factors in the epidermal development and differentiation

2000 - 2000 栄養障害型表皮水疱症における日本人高頻度変異の同定とその迅速診断法の確立

1999 - 2000 Molecular mechanism of the regulation of type VII collagen gene expression : Elucidation of pathogenesis and development therapy for dystophic epidermolysis bullosa

1996 - 1999 EPIDERMAL STEM CELL AND ITS CLINICAL APPLICATION

1996 - 1998 Fundamental study of gene therapy for epidermolysis bullosa : Development of gene therapy targeting keratinocyte

1995 - 1997 尋常性および落葉状天疱瘡抗原遺伝子の表皮特異的発現調節機構の解析

1993 - 1995 Characterization of 5 prime flanking region of 230 kDa bullous pemphigoid antigen gene

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Papers (148)：

玉井克人, 菊池康, 森志保, 森坂広行, 外村香子, 種村篤, 藤本学. 大阪大学皮膚科における栄養障害型表皮水疱症治療法開発. 日本皮膚科学会雑誌. 2024. 134. 1. 102-102
Masashi Akiyama, Takuya Takeichi, Shigaku Ikeda, Akira Ishiko, Michiko Kurosawa, Hiroyuki Murota, Yutaka Shimomura, Tamio Suzuki, Katsuto Tamai, Akio Tanaka, et al. Recent Advances in Clinical Research on Rare Intractable Hereditary Skin Diseases in Japan. The Keio journal of medicine. 2023
Yasushi Kikuchi, Tomoki Tamakoshi, Ryuichi Ishida, Ryosuke Kobayashi, Shiho Mori, Akemi Ishida-Yamamoto, Manabu Fujimoto, Yasufumi Kaneda, Katsuto Tamai. Gene-Modified Blister Fluid-Derived Mesenchymal Stromal Cells for Treating Recessive Dystrophic Epidermolysis Bullosa. The Journal of investigative dermatology. 2023
Takeya Hara, Takashi Shimbo, Tatsuo Masuda, Tomomi Kitayama, Makoto Fujii, Morifumi Hanawa, Kazuha Yokota, Masayuki Endo, Takuji Tomimatsu, Tadashi Kimura, et al. High-mobility group box-1 peptide ameliorates bronchopulmonary dysplasia by suppressing inflammation and fibrosis in a mouse model. Biochemical and biophysical research communications. 2023. 671. 357-365
Ayumu Taniguchi, Kazuya Miyashita, Shota Fukae, Ryo Tanaka, Mami Nishida, Tomomi Kitayama, Yuya Ouchi, Takashi Shimbo, Shigeaki Nakazawa, Kazuaki Yamanaka, et al. Single-cell transcriptome analysis of a rat model of bilateral renal ischemia-reperfusion injury. Biochemistry and biophysics reports. 2023. 33. 101433-101433

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MISC (482)：

岩下瑞穂, 岩山智明, 冨田貴和子, 松本修治, パーン・ポンサティアン, 阪下裕美, 宮下和也, 北山智美, 池上健太郎, 新保敬史, et al. 歯根膜一細胞アトラスの構築. 日本歯周病学会会誌. 2022. 64. 春季特別. 115-115
森志朋, 高木智史, 玉越智樹, 新保敬史, 種村篤, 藤本学, 玉井克人. 表皮水疱症に対する復帰変異モザイク皮膚からの自家培養表皮とメッシュ植皮のハイブリッド移植. 日本皮膚科学会雑誌. 2022. 132. 5. 1343-1343
二階堂雄文, 谷野功典, 王新涛, 佐藤佑樹, 東川隆一, 河俣貴也, 峯村浩之, 玉井克人, 柴田陽光. 感染症基礎から臨床まで HMGB1 fragmentsはPoly(I:C)誘導性急性肺炎を抑制する. 日本呼吸器学会誌. 2022. 11. 増刊. 161-161
玉井克人. 【最近のトピックス2022】皮膚疾患治療のポイント栄養障害型表皮水疱症に対する再生誘導医薬レダセムチドの作用機序と治療効果. 臨床皮膚科. 2022. 76. 5. 135-138
玉井克人. 表皮水疱症治療の現状と展望. 日本皮膚科学会雑誌. 2022. 132. 2. 340-340

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Books (1)：

厚生労働科学研究費補助金難治性疾患克服研究事業表皮水疱症の根治的治療法確立に関する研究研究報告書
[玉井克人] 2010

Education (2)：

1986 - 1990 Hirosaki University Graduate School of Medicine
- 1986 Hirosaki University School of Medicine

Work history (1)：

2010/10 - 現在 Osaka University Graduate School of Medicine Graduate School of Medicine

Awards (1)：

2015/07 - 大阪大学大阪大学総長顕彰研究部門

Association Membership(s) (2)：

日本研究皮膚科学会 , 日本皮膚科学会

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