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J-GLOBAL ID：201801005108769610 Update date: Apr. 18, 2025

Kawatani Makoto

カワタニマコト | Kawatani Makoto

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Affiliation and department：
Job title： Senior Research Scientist

Research field (2)： Applied biochemistry , Chemical biology

Research keywords (4)： Chemical biology , Drug target identification , Cancer , Bone disease

Research theme for competitive and other funds (12)：

2022 - 2025 小分子化合物によるグルコース非依存性がん代謝機構の理解と制御
2018 - 2023 (Chemical biology for controlling ubiquitin function
2019 - 2022 Development of small-molecule inhibitors targeting the metabolic switch in cancer cells
2017 - 2022 -
2016 - 2021 ケミカルバイオロジーを基盤としたがん代謝制御薬剤の開発

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Papers (73)：

Miku Nakahara, Shogo Watanabe, Michio Sato, Hideo Okumura, Makoto Kawatani, Hiroyuki Osada, Kodai Hara, Hiroshi Hashimoto, Kenji Watanabe. Structural and Functional Analyses of Inhibition of Human Dihydroorotate Dehydrogenase by Antiviral Furocoumavirin. Biochemistry. 2024. 63. 10. 1241-1245
Makoto Kawatani, Harumi Aono, Sayoko Hiranuma, Takeshi Shimizu, Makoto Muroi, Toshihiko Nogawa, Tomokazu Ohishi, Shun-Ichi Ohba, Manabu Kawada, Kanami Yamazaki, et al. Identification of a dihydroorotate dehydrogenase inhibitor that inhibits cancer cell growth by proteomic profiling. Oncology research. 2023. 31. 6. 833-844
Takayuki Motoyama, Toshihiko Nogawa, Takeshi Shimizu, Makoto Kawatani, Takeshi Kashiwa, Choong-Soo Yun, Daisuke Hashizume, Hiroyuki Osada. Fungal NRPS-PKS Hybrid Enzymes Biosynthesize New gamma-Lactam Compounds, Taslactams A-D, Analogous to Actinomycete Proteasome Inhibitors. ACS CHEMICAL BIOLOGY. 2023
Hiromasa Yoshioka, Tatsuro Kawamura, Makoto Muroi, Yasumitsu Kondoh, Kaori Honda, Makoto Kawatani, Harumi Aono, Herbert Waldmann, Nobumoto Watanabe, Hiroyuki Osada. Identification of a Small Molecule That Enhances Ferroptosis via Inhibition of Ferroptosis Suppressor Protein 1 (FSP1). ACS Chemical Biology. 2022. 17. 2. 483-491
Shunsuke Kako, Masako Tabuchi, Ken Miyazawa, Miyuki Tanaka, Chisato Minamoto, Yuichiro Asano, Fumika Kimura, Yuki Aoki, Takuma Sato, Makoto Kawatani, et al. Does local injection of reveromycin A inhibit tooth movement without causing systemic side effects?. European Journal of Orthodontics. 2021. 43. 6. 658-664

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MISC (18)：

本山高幸, 野川俊彦, 清水猛, 川谷誠, 二村友史, YUN Choong-Soo, 長田裕之. Isolation of new bioactive natural products by using homologs of a new type secondary metabolism enzyme TAS1. 日本農芸化学会大会講演要旨集(Web). 2020. 2020
河村達郎, 河村達郎, 二村友史, 室井誠, 室井誠, 川谷誠, 川谷誠, SHANG Rchang, JANNING Petra, 近藤恭光, et al. がん細胞に活性酸素種産生を誘導する化合物RKN9055の発見と作用解析. 日本農芸化学会大会講演要旨集(Web). 2019. 2019
浅野雄一郎, 宮澤健, 田渕雅子, 加古駿輔, 木村文香, 川谷誠, 長田裕之, 前田初彦, 後藤滋巳. 新規軟膏(リベロマイシンA)の口腔内局所投与における有用性の検討. 2019. 57. 1. 1-9
佐竹華子, 佐竹華子, 二村友史, 室井誠, 野川俊彦, 川谷誠, 井本正哉, 長田裕之. がん代謝研究を加速するオミックス解析基盤の構築. 日本農芸化学会大会講演要旨集(Web). 2018. 2018
野川俊彦, 高橋俊二, 高橋俊二, 高木海, 関山恭代, 岡野亜紀子, 川谷誠, 清水猛, 長田裕之, 長田裕之. アルコール添加による新規リベロマイシン誘導体の創製と生合成機構の考察. 日本農芸化学会大会講演要旨集(Web). 2015. 2015

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Patents (2)：

新規フラノクマリン誘導体及びその用途
リベロマイシンAまたはその合成中間体の製造法、スピロケタール環含有化合物の製造方法、並びに新規抗癌剤、抗真菌剤および骨疾患治療剤

Lectures and oral presentations (9)：

多面的アプローチによる生理活性化合物の標的同定
(日本薬学会第135年会 2015)
生理活性化合物の標的同定と創薬への試み
(26. 新学術領域研究「天然物ケミカルバイオロジー:分子標的と活性制御」第5回若手研究者ワークショップ 2014)
癌骨転移抑制剤のケミカルバイオロジー研究
(第16回癌と骨病変研究会 2013)
破骨細胞を標的とする小分子化合物の化学遺伝学的解析
(第153回日本獣医学会学術集会 2012)
破骨細胞の機能を制御する小分子のケミカルバイオロジー
(48. 昭和大学High-Tech Research Seminar 2009 2009)

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Education (3)：

2000 - 2003 Keio University Faculty of Science and Technology School of Fundamental Science and Technology
1998 - 2000 Keio University Graduate School of Science and Technology Department of Biomedical Engineering
- 1998 Keio University Faculty of Science and Technology Department of Applied Chemistry

Professional career (1)：

博士(理学) (慶應義塾大学)

Work history (8)：

2022/04 - 現在 RIKEN Center for Sustainable Resource Science Biomolecular Characterization Unit and Chemical Resource Development Unit, Technology Platform Division Senior Research Scientist
2012/04 - 2022/03 RIKEN Center for Sustainable Resource Science (CSRS) Chemical Biology Research Group Senior Research Scientist
2021/04 - 2021/09 国立大学法人埼玉大学非常勤講師
2009/04 - 2012/03 RIKEN ASI Antibiotics Laboratory Scientist
2007/04 - 2009/03 RIKEN DRI Antibiotics Laboratory Postdoctoral Researcher

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Committee career (10)：

2021/05 - 現在 Oncology Letters Editorial Board
2020/10 - 現在日本ケミカルバイオロジー学会産学連携委員会委員
2011/06 - 現在日本がん分子標的治療学会評議員
2009 - 現在 Oncology Research Editorial Board
2022/06 - 日本がん分子標的治療学会第26回学術集会プログラム委員

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Awards (7)：

2021 - The American Association of Orthodontists 2021 Wayne G. Watson Award for Biologic or Experimental Research
2012 - The Japanese Cancer Association The Young Investigator Awards of the Japanese Cancer Association
2009 - RIKEN RIKEN Research Incentive Award
2009 - The Japan Society for Bioscience, Biotechnology, and Agrochemistry The Excellent Paper Award Published in Bioscience, Biotechnology, & Biochemistry
2009 - The Japanese Association for Molecular Target Therapy of Cancer The Young Investigator Award of the Japanese Association for Molecular Target Therapy of Cancer

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Association Membership(s) (4)：

JAPANESE SOCIETY FOR CHEMICAL BIOLOGY , JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY , THE JAPANESE ASSOCIATION FOR MOLECULAR TARGET THERAPY OF CANCER , THE JAPANESE CANCER ASSOCIATION

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