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J-GLOBAL ID:201801005116439654   Update date: Jan. 06, 2025

Isaji Tomoya

Isaji Tomoya
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Research field  (1): Pathobiochemistry
Research theme for competitive and other funds  (10):
  • 2023 - 2027 糖転移酵素GnT-IIIによるがんの薬剤耐性の制御とその分子機序の解明
  • 2022 - 2025 Regulatory mechanism of sialylation of N-glycans by focal adhesion kinase (FAK) and its biological significance
  • 2019 - 2023 Functions of glycosylation in integrin-mediated outside-in and inside-out signaling
  • 2019 - 2022 Regulation and significance of new sialylated glycan biosynthesis via integrin alpha3
  • 2015 - 2019 Analysis of sialylation on cell biological functions
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Papers (58):
  • Zhiwei Zhang, Tomoya Isaji, Yoshiyuki Oyama, Jianwei Liu, Zhiwei Xu, Yuhan Sun, Tomohiko Fukuda, Haojie Lu, Jianguo Gu. O-GlcNAcylation of Focal Adhesion Kinase Regulates Cell Adhesion, Migration, and Proliferation via the FAK/AKT Pathway. Biomolecules. 2024
  • Tiangui Wu, Yuhan Sun, Dan Wang, Tomoya Isaji, Tomohiko Fukuda, Chiharu Suzuki, Hisatoshi Hanamatsu, Takashi Nishikaze, Hiroki Tsumoto, Yuri Miura, et al. The acetylglucosaminyltransferase GnT-III regulates erythroid differentiation through ERK/MAPK signaling. The Journal of biological chemistry. 2024. 108010-108010
  • Tomoya Isaji, Jianguo Gu. Novel regulatory mechanisms of N-glycan sialylation: Implication of integrin and focal adhesion kinase in the regulation. Biochimica et biophysica acta. General subjects. 2024. 1868. 6. 130617-130617
  • Rio Yamamoto, Ryosuke Segawa, Jianwei Liu, Tomoya Isaji, Jianguo Gu, Masahiro Hiratsuka, Noriyasu Hirasawa. Effect of N-glycosylation on constitutive signal transduction by mutated cytokine receptor-like factor 2. Biochimica et biophysica acta. General subjects. 2023. 1867. 11. 130465-130465
  • Yuhan Sun, Tomoya Isaji, Yoshiyuki Oyama, Xing Xu, Jianwei Liu, Hisatoshi Hanamatsu, Ikuko Yokota, Nobuaki Miura, Jun-Ichi Furukawa, Tomohiko Fukuda, et al. Focal-adhesion kinase regulates the sialylation of N-glycans via the PI4KIIα-PI4P pathway. The Journal of biological chemistry. 2023. 105051-105051
more...
MISC (3):
  • Tomoya Isaji, Yuya Sato, Tomohiko Fukuda, Jianguo Gu. N-Glycosylation on I-Like Domain of beta1 Integrin is Essential for its Expression and Biological Functions. GLYCOBIOLOGY. 2008. 18. 11. 991-991
  • 小谷 典弘, 顧 建国, 伊左治 知弥, 宇高 恵子, 谷口 直之, 本家 孝一. 新規細胞膜上分子間相互作用解析法による分子間相互作用の生化学的可視化. 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2007. 80回・30回. 2T13-8
  • 顧 建国, 伊左治 知弥, 谷口 直之. 【糖鎖機能の解明と疾患の診断と治療にむけて】がんの転移とインテグリンの糖鎖. Medical Science Digest. 2004. 30. 12. 495-498
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