Isaji Tomoya

Research field (1)： Pathobiochemistry

Research theme for competitive and other funds (10)：

2023 - 2027 糖転移酵素GnT-IIIによるがんの薬剤耐性の制御とその分子機序の解明
2022 - 2025 Regulatory mechanism of sialylation of N-glycans by focal adhesion kinase (FAK) and its biological significance
2019 - 2023 Functions of glycosylation in integrin-mediated outside-in and inside-out signaling
2019 - 2022 Regulation and significance of new sialylated glycan biosynthesis via integrin alpha3
2015 - 2019 Analysis of sialylation on cell biological functions

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Papers (57)：

Jianwei Liu, Tomoya Isaji, Sachiko Komatsu, Yuhan Sun, Xing Xu, Tomohiko Fukuda, Tsutomu Fujimura, Shinichiro Takahashi, Jianguo Gu. BRCC36 associates with FLT3-ITD to regulate its protein stability and intracellular signaling in acute myeloid leukemia. Cancer science. 2024
Xing Xu, Tomohiko Fukuda, Jun Takai, Sayaka Morii, Yuhan Sun, Jianwei Liu, Shiho Ohno, Tomoya Isaji, Yoshiki Yamaguchi, Miyako Nakano, et al. Exogenous L-fucose attenuates neuroinflammation induced by lipopolysaccharide. The Journal of biological chemistry. 2023. 105513-105513
Yuhan Sun, Tomoya Isaji, Yoshiyuki Oyama, Xing Xu, Jianwei Liu, Hisatoshi Hanamatsu, Ikuko Yokota, Nobuaki Miura, Jun-Ichi Furukawa, Tomohiko Fukuda, et al. Focal-adhesion kinase regulates the sialylation of N-glycans via the PI4KIIα-PI4P pathway. The Journal of biological chemistry. 2023. 105051-105051
Wanli Song, Caixia Liang, Yuhan Sun, Sayaka Morii, Shin Yomogida, Tomoya Isaji, Tomohiko Fukuda, Qinglei Hang, Akiyoshi Hara, Miyako Nakano, et al. Expression of GnT-III decreases chemoresistance via negatively regulating P-glycoprotein expression: Involvement of the TNFR2-NF-κB signaling pathway. The Journal of biological chemistry. 2023. 299. 4. 103051-103051
Wanli Song, Tomoya Isaji, Miyako Nakano, Caixia Liang, Tomohiko Fukuda, Jianguo Gu. O-GlcNAcylation regulates β1,4-GlcNAc-branched N-glycan biosynthesis via the OGT/SLC35A3/GnT-IV axis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2022. 36. 2. e22149

ｍore...

MISC (3)：

Tomoya Isaji, Yuya Sato, Tomohiko Fukuda, Jianguo Gu. N-Glycosylation on I-Like Domain of beta1 Integrin is Essential for its Expression and Biological Functions. GLYCOBIOLOGY. 2008. 18. 11. 991-991
小谷典弘, 顧建国, 伊左治知弥, 宇高恵子, 谷口直之, 本家孝一. 新規細胞膜上分子間相互作用解析法による分子間相互作用の生化学的可視化. 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2007. 80回・30回. 2T13-8
顧建国, 伊左治知弥, 谷口直之. 【糖鎖機能の解明と疾患の診断と治療にむけて】がんの転移とインテグリンの糖鎖. Medical Science Digest. 2004. 30. 12. 495-498

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