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J-GLOBAL ID：201801005228517917 Update date: Sep. 29, 2024

Yoshie Umehara

ウメハラヨシエ | Yoshie Umehara

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Affiliation and department：

Research field (3)： Dermatology , Neuropathology , Developmental biology

Research theme for competitive and other funds (5)：

2016 - 2019 Elucidation of mechanisms of peripheral itch hypersensitivity focusing on dorsal root ganglia and development for its therapeutic application
2016 - 2018 Effect of antimicrobial peptide cathelicidin on atopic dermatitis
2014 - 2017 Effect of skin-derived antimicrobial peptide cathelicidin LL-37 on the regulation of skin barrier function
2014 - 2016 A method to differentiate peripheral neurons mediating itch from human induced pluripotent stem cells
2014 - 2016 Cathelicidin LL-37 induces semaphorin 3A expression in human epidermal keratinocytes: implications for possible application to pruritus

Papers (68)：

梅原芳恵, Trujillo Valentin, 彭戈, 岳海楠, 奥村康, 小川秀興, ニヨンサバ・フランソワ. Calcitriolはアトピー性皮膚炎モデルマウスの皮膚バリア機能を改善する. 日本皮膚科学会雑誌. 2024. 134. 5. 1487-1487
Juan Valentin Trujillo-Paez, Ge Peng, Hai Le Thanh Nguyen, Masahiro Nakamura, Yoshie Umehara, Hainan Yue, Risa Ikutama, Miho Takahashi, Shigaku Ikeda, Hideoki Ogawa, et al. Calcitriol modulates epidermal tight junction barrier function in human keratinocytes. Journal of dermatological science. 2024. 114. 1. 13-23
Yoshie Umehara, Juan Valentin Trujillo-Paez, Hainan Yue, Ge Peng, Hai Le Thanh Nguyen, Ko Okumura, Hideoki Ogawa, François Niyonsaba. Calcitriol, an Active Form of Vitamin D3, Mitigates Skin Barrier Dysfunction in Atopic Dermatitis NC/Nga Mice. International Journal of Molecular Sciences. 2023. 24. 11. 9347-9347
H. Yue, G. Peng, Y. Umehara, L. Nguyen, A. Ikeda, K. Okumura, H. Ogawa, S. Ikeda, F. Niyonsaba. 330 The aryl hydrocarbon receptor contributes to histamine-evoked itch with the involvement of TRPV1 in dorsal root ganglia. Journal of Investigative Dermatology. 2023. 143. 5. S57-S57
Y. Umehara, M. Takahashi, H. Yue, J. Trujillo-Paez, G. Peng, L. Nguyen, K. Okumura, H. Ogawa, F. Niyonsaba. 1486 Skin-derived antimicrobial peptides human β-defensins induce the secretion of angiogenic factor angiogenin from human dermal fibroblasts. Journal of Investigative Dermatology. 2023. 143. 5. S255-S255

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MISC (80)：

岳海楠, 彭戈, 梅原芳恵, 奥村康, 小川秀興, 池田志斈, ニヨンサバ・フランソワ. ヒスタミンによって誘発される痒みに対する芳香族炭化水素受容体の関与. 日本皮膚免疫アレルギー学会総会学術大会プログラム・抄録集. 2022. 52回. 185-185
グエン・レータインハイ, 梅原芳恵, 奥村康, 小川秀興, 池田志斈, ニヨンサバフランソワ. DNCB誘発皮膚炎様マウスモデルにて、insulin-like growth factor binding protein 5由来抗菌ペプチドは、LRP1受容体を介して皮膚炎症状を改善する(The antimicrobial peptide derived from insulin-like growth factor binding-protein 5 alleviates dermatitis symptoms in the DNCB-induced dermatitis-like mouse model through LRP1 receptor). 日本皮膚免疫アレルギー学会総会学術大会プログラム・抄録集. 2022. 52回. 187-187
PENG Ge, TSUKAMOTO Saya, UMEHARA Yoshie, OKUMURA Ko, OGAWA Hideoki, IKEDA Shigaku, NIYONSABA Francois, NIYONSABA Francois. Human β defensin-3 alleviates atopic dermatitis-like symptoms through aryl hydrocarbon receptor signaling pathway. アレルギー. 2022. 71. 6/7
THANH Nguyen Hai Le, PENG Ge, VALENTIN Juan Trujillo-Paez, HAINAN Yue, IKUTAMA Risa, TAKAHASHI Miho, UMEHARA Yoshie, OKUMURA Ko, OGAWA Hideoki, IKEDA Shigaku, et al. The antimicrobial peptide AMP-IBP5 alleviates skin symptoms in a hapten-induced atopic dermatitis-like model. アレルギー. 2022. 71. 6/7
YUE Hainan, PENG Ge, UMEHARA Yoshie, NGUYEN Hai Le Thanh, TSUKAMOTO Saya, IKEDA Arisa, TRUJILLO-PAEZ Juan Valentin, OKUMURA Ko, OGAWA Hideoki, IKEDA Shigaku, et al. Involvement of the aryl hydrocarbon receptor in histamine-evoked acute itch. 日本研究皮膚科学会年次学術大会・総会プログラム. 2022. 47th

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Patents (1)：

掻痒性皮膚疾患の治療又は予防剤

Education (3)：

2010 - 2013 北里大学大学院理学研究科生物科学専攻博士課程
2008 - 2010 北里大学大学院理学研究科生物科学専攻修士課程
2004 - 2008 Kitasato University School of Science

Work history (2)：

2018/04 - 現在順天堂大学大学院医学研究科アトピー疾患研究センター助教
2013/04 - 2018/03 順天堂大学大学院医学研究科環境医学研究所博士研究員

Awards (6)：

2023/04 - 公益社団法人ビタミン・バイオファクター協会 2023(令和5)年度研究助成
2023/04 - 日本私立学校振興・共済事業団 2023年度女性研究者奨励金
2021/06 - 第120 回日本皮膚科学会総会優秀演題賞
2020/04 - 一般財団法人リディアオリリー記念ピアス皮膚科学振興財団令和2年度指定課題研究助成金
2018 - 順天堂大学共同プロジェクト研究費

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