Nagai Naoko

Affiliation and department：

Research field (3)： Functional biochemistry , Metabolism and endocrinology , Pathobiochemistry

Research keywords (7)：エネルギー代謝 , 視床下部 , レプチン , 生活習慣病 , へパラン硫酸6-O-硫酸基転移酵素 , へパラン硫酸 , グリコサミノグリカン

Research theme for competitive and other funds (6)：

2021 - 2024 Elucidation of the control mechanism of leptin signal transduction by hypothalamic heparan sulfate
2013 - 2017 Role of proteoglycans in diseases: Regulation of cell behavior and maintenance of tissue structure
2010 - 2012 Elucidation of the mechanism involved in energy metabolic regulation by heparan sulfate
2010 - 2012 Roles of chondroitin sulfate proteoglycan in maintenance of tissue structure and its remodeling under pathological conditions
2006 - 2008 Elucidation of the role of heparan sulfate 6O-sulfotransferase to the progression of Alzheimer's disease

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Papers (20)：

Naoko Nagai, Tatsumasa Shioiri, Sonoko Hatano, Nobuo Sugiura, Hideto Watanabe. Regulatory role of Heparan sulfate in leptin signaling. Cellular Signalling. 2024. 124. 111456-111456
Sohyun Moon, Hiu Ham Lee, Stephanie Archer-Hartmann, Naoko Nagai, Zainab Mubasher, Mahima Parappurath, Laiba Ahmed, Raddy L Ramos, Koji Kimata, Parastoo Azadi, et al. Knockout of the intellectual disability-linked gene Hs6st2 in mice decreases heparan sulfate 6-O-sulfation, impairs dendritic spines of hippocampal neurons, and affects memory. Glycobiology. 2024. 34. 2
Tadai K, Shioiri T, Tsuchimoto J, Nagai N, Watanabe H, Sugiura N. Interaction of receptor type of protein tyrosine phosphatase sigma (RPTPσ) with a glycosaminoglycan library. Journal of biochemistry. 2018. 164. 1. 41-51
Sonoko Hatano, Naoko Nagai, Nobuo Sugiura, Jun Tsuchimoto, Zenzo Isogai, Koji Kimata, Akinobu Ota, Sivasundaram Karnan, Yoshitaka Hosokawa, Hideto Watanabe. Versican A-subdomain is required for its adequate function in dermal development. Connective tissue research. 2018. 59. 2. 178-190
Kanda Fanhchaksai, Futoshi Okada, Naoko Nagai, Peraphan Pothacharoen, Prachya Kongtawelert, Sonoko Hatano, Shinji Makino, Tomoyuki Nakamura, Hideto Watanabe. Host stromal versican is essential for cancer-associated fibroblast function to inhibit cancer growth. INTERNATIONAL JOURNAL OF CANCER. 2016. 138. 3. 630-641

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MISC (43)：

永井尚子, 渡辺秀人. 血清コンドロイチン硫酸量:健常者の健康診断データとの相関. 日本生化学会大会(Web). 2022. 95th
永井尚子, 桝正幸, 桝和子, 木全弘治, 渡辺秀人. 視床下部ヘパラン硫酸によるレプチンシグナル伝達制御の検討. 日本生化学会大会(Web). 2020. 93rd
永井尚子, 幡野その子, 杉浦信夫, 木全弘治, 渡辺秀人. 視床下部背内側核に発現しているヘパラン硫酸6-O-硫酸基転移酵素-2の解析. 日本糖質学会年会要旨集. 2019. 38th
永井尚子, 幡野その子, 杉浦信夫, 木全弘治, 渡辺秀人. 中枢神経系に存在するヘパラン硫酸による体温調節への関与. 日本生化学会大会(Web). 2018. 91st
FANHCHAKSAI Kanda, FANHCHAKSAI Kanda, KLANGJORHOR Jeerawan, KHUMMUANG Saichit, KHUMMUNG Saichit, ISLAM Shamima, 永井尚子, 幡野その子, KONTAWELERT Prachya, KASINRERK Watchara, et al. バーシカンがつくるがん微小環境とその制御. 日本結合組織学会学術大会抄録集. 2017. 49th. 55

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Books (6)：

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Lectures and oral presentations (23)：

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Education (3)：

Work history (3)：

2001/04 - 現在 Aichi Medical University Institute for Molecular Science of Medicine
2000/09 - 2001/03 長寿科学振興財団リサーチ・レジデント
1997/04 - 1999/03 Japan Society for the Promotion of Science

Association Membership(s) (3)：

日本生化学会 , 日本分子生物学会 , 日本糖質学会

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