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J-GLOBAL ID：201801005605222757 Update date: Sep. 09, 2024

Tatsuya Yamazaki

ヤマザキタツヤ | Tatsuya Yamazaki

Affiliation and department：
Job title： Senior Assistant professor

Research field (2)： Immunology , Virology

Research keywords (10)：抗体工学 , Antibody gene , monoclonal antibody , DNA immunizaiton , Influenza virus , Vaccine , IgA抗体 , Gene therapy , Allergy , IgE抗体

Research theme for competitive and other funds (7)：

2023 - 2026 トル様受容体RP105特異抗体を基盤とした遺伝子ワクチンアジュバントの開発
2022 - 2024 自然免疫受容体RP105を介した新たなB細胞活性化メカニズムの解明
2019 - 2023 The development of a vaccine adjuvant using an agonistic monoclonal antibody against TLR
2018 - 2021 抗体遺伝子を応用した新規ワクチン療法の開発
2016 - 2018 中和抗体遺伝子発現プラスミドを用いた新規受動免疫法による感染症治療

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Papers (15)：

Tatsuya Yamazaki, Kenta Iwasaki, Susumu Tomono, Masaki Imai, Yuko Miwa, Masato Shizuku, Satoshi Ashimine, Kohei Ishiyama, Masanori Inui, Daisuke Okuzaki, et al. Human RP105 monoclonal antibody enhances antigen-specific antibody production in unique culture conditions. iScience. 2024. 27. 9
Sajid Iftekhar Chowdhury, Masanori Inui, Tatsuya Yamazaki, Susumu Tomono, Hidekazu Takagi, Mrityunjoy Biswas, Shin-Ichiroh Saitoh, Kensuke Miyake, Sachiko Akashi-Takamura. The anti-TLR4 monoclonal antibody Sa15-21 enhances inflammatory cytokine production in LPS-stimulated macrophages. FEBS Letters. 2023
Mrityunjoy Biswas, Tatsuya Yamazaki, Susumu Tomono, Sivasundaram Karnan, Hidekazu Takagi, Isao Ichimonji, Masanori Inui, Fumiaki Nagaoka, Yoshitaka Hosokawa, Sachiko Akashi-Takamura. Cell surface expression of human RP105 depends on N -glycosylation of MD -1. FEBS Letters. 2022. 596. 24. 3211-3231
Fumiaki Nagaoka, Tatsuya Yamazaki, Sachiko Akashi-Takamura, Makoto Itoh. Detection of Urinary Antibodies and Its Application in Epidemiological Studies for Parasitic Diseases. Vaccines. 2021. 9. 7. 778
Tatsuya Yamazaki, Mrityunjoy Biswas, Kouyu Kosugi, Maria Nagashima, Masanori Inui, Susumu Tomono, Hidekazu Takagi, Isao Ichimonji, Fumiaki Nagaoka, Akira Ainai, et al. A Novel Gene Delivery Vector of Agonistic Anti-Radioprotective 105 Expressed on Cell Membranes Shows Adjuvant Effect for DNA Immunization Against Influenza. Frontiers in Immunology. 2020. 11. 606518-606518

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MISC (9)：

山崎達也, 髙村(赤司) 祥子. 抗体遺伝子を用いたウイルス感染症制御への挑戦. エンドトキシン・自然免疫研究. 2024. 24. 1-8
Control of virus infection using antibody gene-based delivery. 2023. 55. 11. 921-925
山崎達也, 高村(赤司)祥子. コレラ菌抽出物によるIgE の不活化とアナフィラキシーの抑制. 日本エンドトキシン・自然免疫研究会. 2019. 22. 72-78
伴野勧, 長岡史晃, 一文字功, 山崎達也, 乾匡範, 高木秀和, 伊藤誠, 高村(赤司) 祥子. Ceramide phosphoethanolamineによるArginase-1発現誘導. 日本生化学会大会プログラム・講演要旨集. 2019. 92回. [2P-042]
Tatsuya Yamazaki, Sachiko Akashi-Takamura. Could a sugar chain on IgE be a new target for therapy for allergy?. Glycoforum. 2019. 22. 5. A15

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Lectures and oral presentations (26)：

TLRファミリー分子RP105に対するアゴニスト抗体はインフルエンザウイルス感染予防のための遺伝子免疫でアジュバント効果を示す
(2022年度東海乳酸菌研究会総会・研究発表会 2023)
Recombinant anti-RP105 provides an adjuvant effect for gene immunization against influenza
(The 51th Annual Meeting of the Japanese Society for Immunology 2022)
ヒトRP105の細胞膜上への発現はMD-1に付加したN結合型糖鎖に依存する
(第27回日本エンドトキシン・自然免疫研究会 2022)
自然免疫受容体RP105に対するアゴニスト抗体を用いた B細胞活性化とその応用
(第10回Transplant Immunology Forum 2022)
Agonistic anti-radioprotective 105 shows adjuvant effect for DNA immunization against influenza
(The 50th Annual Meeting of the Japanese Society for Immunology 2021)

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Work history (4)：

2021/03 - 現在 Aichi Medical University Department of Microbiology and Immunology Senior Assistant Professor
2016/04 - 2021/02 Aichi Medical University School of Medicine Department of Microbiology and Immunology Assistant Professor
2013/01 - 2016/03 The University of Tokyo The Institute of Medical Science International Research Center for Infection Diseases Division of Viral Infection Project researcher
2011/04 - 2012/12 Tokyo Metropolitan Institute of Medical Science Neurovirology Project project researcher

Awards (3)：

2020/10 - Japan Endotoxin and Innate Immunity Society Japan Endotoxin and Innate Immunity Society First place
2017/12 - 第23回日本エンドトキシン・自然免疫研究会奨励賞(優秀賞)
2014/01 - 第3回Negative strand virus-Japan ベストオーラルプレゼンテーション賞

Association Membership(s) (3)：

Japan Endotoxin and Innate Immunity Society , THE JAPANESE SOCIETY FOR VIROLOGY , THE JAPANESE SOCIETY FOR IMMUNOLOGY

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