Yokoe Shunichi

ヨコエシュンイチ | Yokoe Shunichi

Affiliation and department：

Research field (1)： Pharmacology

Research keywords (4)：心不全 , O-GlcNAc , Ubiquitination , Phospholamban

Research theme for competitive and other funds (8)：

2024 - 2028 O-GlcNAc修飾によるSOCE活性を応用した糖尿病網膜症・黄斑症の新規治療戦略
2022 - 2025 心不全の進行におけるSOCE制御因子SARAFとその安定化分子ALG-2の関与
2021 - 2023 STIM1に着目した心リハ効果の分子機構の解明と相乗効果が期待できる薬物の探索
2019 - 2022 Elucidation of the mechanism of PLN degradation by Parkin
2017 - 2019 Identification and functional analysis of ubiquitin ligases that interact with PLN.

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Papers (29)：

Hirofumi Morihara, Shunichi Yokoe, Shigeo Wakabayashi, Shinji Takai. TMEM182 inhibits myocardial differentiation of human iPS cells by maintaining the activated state of Wnt/β-catenin signaling through an increase in ILK expression. FASEB BioAdvances. 2024. 6. 11. 565-579
Makoto Shirakawa, Shunichi Yokoe, Takatoshi Nakagawa, Kazumasa Moriwaki, Toshihisa Takeuchi, Michio Asahi. Rapamycin and Starvation Mitigate Indomethacin-Induced Intestinal Damage through Preservation of Lysosomal Vacuolar ATPase Integrity. The Journal of pharmacology and experimental therapeutics. 2024. 390. 1. 108-115
Mahito Matsuno, Shunichi Yokoe, Takehiro Nagatsuka, Hirofumi Morihara, Kazumasa Moriwaki, Michio Asahi. O-GlcNAcylation-induced GSK-3β activation deteriorates pressure overload-induced heart failure via lack of compensatory cardiac hypertrophy in mice. Frontiers in Endocrinology. 2023. 14
Shunichi Yokoe, Tetsuya Hayashi, Takatoshi Nakagawa, Ryuji Kato, Yoshio Ijiri, Takehiro Yamaguchi, Yasukatsu Izumi, Minoru Yoshiyama, Michio Asahi. Augmented O-GlcNAcylation exacerbates right ventricular dysfunction and remodeling via enhancement of hypertrophy, mitophagy, and fibrosis in mice exposed to long-term intermittent hypoxia. Hypertension research : official journal of the Japanese Society of Hypertension. 2023. 46. 3. 667-678
Atsuo Nomura, Shunichi Yokoe, Kiichiro Tomoda, Takatoshi Nakagawa, Francisco Javier Martin-Romero, Michio Asahi. Fluctuation in O-GlcNAcylation inactivates STIM1 to reduce store-operated calcium ion entry via downregulation of Ser621 phosphorylation. Journal of Biological Chemistry. 2020. jbc.RA120.014271-jbc.RA120.014271

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MISC (9)：

Michio Asahi, Shunichi Yokoe. Phospholamban is degraded through ubiquitin-proteasome pathway by pVHL in failing hearts. FASEB JOURNAL. 2017. 31
Shunichi Yokoe, David H. MacLennan, Michio Asahi. Phospholamban is localized in autophagosome in dilated cardiomyopathy mouse model, TgPLN(R9C) mice. FASEB JOURNAL. 2016. 30
Allen C. Teng, Tetsuaki Miyake, Shunichi Yokoe, Liyong Zhang, Luis M. Rezende, Parveen Sharma, David H. MacLennan, Peter Liu, Anthony O. Gramolini. Metformin Increases Degradation of Ubiquitinylated Phospholamban via Autophagy in Cardiomyocytes. CIRCULATION RESEARCH. 2015. 117
Shunichi Yokoe, Elena Zvaritch, Olga Sizova, Tetsuaki Miyake, Allen Teng, Anthony Gramolini, David MacLennan, Michio Asahi. Lethal Arg9Cys phospholamban mutation increases the mitochondrial fission protein (Drp-1) activity. FASEB JOURNAL. 2015. 29
Shunichi Yokoe, Takatoshi Nakagawa, Keiichiro Suzuki, Michio Asahi. Cardiac dysfunction caused by O-GlcNAcylation of phospholamban. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2010. 112. 246P-246P

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Lectures and oral presentations (12)：

O-GlcNAc修飾を標的とした糖尿病網膜症の新規治療戦略
(第44回日本眼薬理学会 2024)
SARAF and ALG-2 are degraded under the ER stress condition in heart failure
(第96回日本薬理学会年会)
Phospholamban is degraded by parkin-mediated ubiquitination in failing heart
(第95回日本薬理学会年会)
Phospholamban is downregulated by parkin-mediated degradation in failing heart
(第93回日本薬理学会年会)
Sarcolipin is O-GlcNAcylated at Ser4 and Thr5 in mouse hearts to regulate SERCA activity

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Professional career (1)：

医学(博士)

Association Membership(s) (1)：

THE JAPANESE PHARMACOLOGICAL SOCIETY

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