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J-GLOBAL ID：201801006089596005   Update date: Feb. 10, 2025

Chen I-Shan

チン イサン | Chen I-Shan
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Affiliation and department：
Wakayama Medical University Department of Pharmacology, School of Medicine

About Wakayama Medical University Department of Pharmacology, School of Medicine


Job title： Lecturer (full-time)
Research field  (2)： Physiology ,  Pharmacology
Research theme for competitive and other funds  (9)：
  • 2022 - 2027 先天性疾患におけるイオンチャネル機能異常の機序解明および新規治療薬の開発
  • 2023 - 2026 チャネルにおけるイオン透過と非典型的膜電位依存性ゲーティングのカップリングの検証
  • 2023 - 2026 GIRKチャネルの病因性変異による異常イオン透過機構の解明と異常透過抑制薬の探索
  • 2022 - 2023 新規メカニズムに基いた先天性神経難病の治療薬の開発
  • 2020 - 2023 チャネルのイオン選択性異常を是正する作用薬の同定:遺伝性チャネル病の治療に向けて
Show all
Papers (15)：
  • Chang Liu, I-Shan Chen, Muruj Barri, Ruth Murrell-Lagnado, Yoshihiro Kubo. Structural determinants of M2R involved in inhibition by Sigma-1R. The Journal of biological chemistry. 2024. 108006-108006
  • Chang Liu, I-Shan Chen, Michihiro Tateyama, Yoshihiro Kubo. Structural determinants of the direct inhibition of GIRK channels by Sigma-1 receptor antagonist. The Journal of biological chemistry. 2024. 107219-107219
  • I-Shan Chen, Jumpei Yasuda, Takuya Notomi, Tomoe Y Nakamura. Licorice metabolite 18β-glycyrrhetinic acid activates G protein-gated inwardly rectifying K+ channels. British journal of pharmacology. 2024. 181. 3. 447-463
  • Sakiko Matsumura, Jumpei Yasuda, Takuya Notomi, Yoshihiro Suzuki, I-Shan Chen, Daichi Murakami, Muneki Hotomi, Tomoe Y Nakamura. Direct toxicity of cigarette smoke extract on cardiac function mediated by mitochondrial dysfunction in Sprague-Dawley rat ventricular myocytes and human induced pluripotent stem cell-derived cardiomyocytes. PloS one. 2024. 19. 1. e0295737
  • Ivan Gando, Manuel Becerra Flores, I-Shan Chen, Hua-Qian Yang, Tomoe Y Nakamura, Timothy J Cardozo, William A Coetzee. CL-705G: a novel chemical Kir6.2-specific KATP channel opener. Frontiers in pharmacology. 2023. 14. 1197257-1197257
ｍore...
MISC (8)：
  • Yasuda Jumpei, Matsumura Sakiko, Notomi Takuya, Chen I-Shan, Nakamura-Nishitani Tomoe Y. Cigarette smoke extract (CSE) directly induces cardiomyocyte dysfunction in rat and human iPS-derived cardiomyocytes thorough abnormal intracellular Ca2+ dynamics and mitochondrial dysfunction. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2023. 97. 2-B-P-056
  • 陳 以珊, 久保 義弘. K+チャネルのしくみ GIRKチャネルの、小分子による新規機能調節機構. 心電図. 2020. 40. 2. 107-113
  • I-Shan Chen, Chang Liu, Michihiro Tateyama, Izhar Karbat, Motonari Uesugi, Eitan Reuveny, Yoshihiro Kubo. Inhibitory Mechanisms of G-protein-gated Inwardly Rectifying K+ Channel by Antihistamines. BIOPHYSICAL JOURNAL. 2020. 118. 3. 117A-117A
  • Atsushi Suzuki, Jun Ishii, Aya Yoshida, Naoya Yamguchi, Tatsushi Tanaka, Kohei Aoyama, Michihiro Tateyama, I-Shan Chen, Yoshihiro Kubo, Toru Kimura, et al. Homozygous loss-of-function mutation in the SLC26A7 gene coding a novel iodide transporter causes goitrous congenital hypothyroidism. HORMONE RESEARCH IN PAEDIATRICS. 2019. 91. 36-36
  • I-Shan Chen, Michihiro Tateyama, Yuko Fukata, Motonari Uesugi, Yoshihiro Kubo. Effects and Activation Mechanisms of Ivermectin on G-Protein-Gated Inwardly Rectifying Potassium Channels. BIOPHYSICAL JOURNAL. 2018. 114. 3. 301A-301A
ｍore...
Education (3)：
  • 2010 - 2014 Osaka University Graduate School of Medicine PhD
  • 2007 - 2009 Kaohsiung Medical University Department of Pharmacology, School of Medicine, College of Medicine Master
  • 2003 - 2007 Kaohsiung Medical University School of Pharmacy BS
Work history (4)：
  • 2021/04 - 現在 Wakayama Medical University Department of Pharmacology, School of Medicine Lecturer (full-time)
  • 2015/04 - 2021/03 The Graduate University for Advanced Studies Department of Physiological Sciences, School of Life Science Assistant Professor
  • 2015/04 - 2021/03 National Institute for Physiological Sciences Division of Biophysics and Neurobiology Project Assistant Professor
  • 2014/04 - 2015/03 Osaka University Department of Pharmacology, Graduate School of Medicine Postdoctoral Researcher
Awards (3)：
  • 2024/03 - 日本生理学会 第25回日本生理学会奨励賞
  • 2024/02 - 和歌山県立医科大学 令和5年度学術論文奨励賞
  • 2018/03 - The Physiological Society of Japan 2018 Hiroshi and Aya Irisawa Memorial Promotion Award for Young Physiologists
Association Membership(s) (4)：
THE JAPAN NEUROSCIENCE SOCIETY ,  THE PHYSIOLOGICAL SOCIETY OF JAPAN ,  THE JAPANESE PHARMACOLOGICAL SOCIETY ,  Biophysical Society
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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