Rchr
J-GLOBAL ID：201801006158765434   Update date: Aug. 29, 2024

Kobayashi Koichi S

Kobayashi Koichi S
Affiliation and department：
Hokkaido University Graduate School of Medicine

About Hokkaido University Graduate School of Medicine


Job title： Professor
Homepage URL  (1)： https://hokudaiimmunology.wixsite.com/kobayashi
Research field  (1)： Immunology
Research keywords  (1)： Innate Immunity, NLR proteins, TLRs, NOD2, NLRC5, MHC class I, cancer immunity, SARS-CoV-2
Research theme for competitive and other funds  (5)：
  • 2023 - 2025 エピゲノム編集を用いた新規肺癌免疫療法の開発
  • 2022 - 2025 Development of novel anti-viral therapeuticing an advanced screening technologys us
  • 2022 - 2025 The role of MHC class I transactivator NLRC5 in COVID-19
  • 2020 - 2022 プロテオーム解析とCROP-seq技術を用いた新規MHC-I遺伝子誘導因子の同定
  • 2018 - 2020 Novel biomarkers for the immune checkpoint inhibitors for cancer
Papers (86)：
  • Baohui Zhu, Ryota Ouda, Yusuke Kasuga, Paul de Figueiredo, Koichi S Kobayashi. NLRC5/MHC class I transactivator: A key target for immune escape by SARS-CoV-2. BioEssays : news and reviews in molecular, cellular and developmental biology. 2024. 46. 4. e2300109
  • Xin Sun, Toshiyuki Watanabe, Yoshitaka Oda, Weidong Shen, Alaa Ahmad, Ryota Ouda, Paul de Figueiredo, Hidemitsu Kitamura, Shinya Tanaka, Koichi S Kobayashi. Targeted demethylation and activation of NLRC5 augment cancer immunogenicity through MHC class I. Proceedings of the National Academy of Sciences of the United States of America. 2024. 121. 6. e2310821121
  • Yusuke Kasuga, Ryota Ouda, Masashi Watanabe, Xin Sun, Miki Kimura, Shigetsugu Hatakeyama, Koichi S Kobayashi. FBXO11 constitutes a major negative regulator of MHC class II through ubiquitin-dependent proteasomal degradation of CIITA. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 24. e2218955120
  • Justine Mathé, Mohamed Benhammadi, Koichi S Kobayashi, Sylvie Brochu, Claude Perreault. Regulation of MHC Class I Expression in Lung Epithelial Cells during Inflammation. Journal of immunology (Baltimore, Md. : 1950). 2022. 208. 5. 1021-1033
  • Ying-Shiuan Chen, Jia Li, Sultan Neja, Sabeeta Kapoor, Jorge Tovar Perez, Chakrapani Tripathi, Rani Menon, Arul Jayaraman, Kyongbum Lee, Wan Dashwood, et al. Metabolomics of Acute vs. Chronic Spinach Intake in an Apc-Mutant Genetic Background: Linoleate and Butanoate Metabolites Targeting HDAC Activity and IFN-γ Signaling. Cells. 2022. 11. 3. 573-573
ｍore...
MISC (4)：
Patents (3)：
  • A novel target to regulate bone mass
  • IRAK-M is a negative regulators of Toll-like receptor signaling
  • RIP2: A mediator of signaling in the innate and adaptive immune systems
Books (2)：
  • 体の中の”小さな生態系”腸内フローラによる免疫ホメオスタシスNOD2による消化管恒常性維持機構
    2011
  • 自然免疫TLRのネガティブフィードバック調節機構
    2003
Education (2)：
  • 1998 - Chiba University Graduate School of Medicine, PhD
  • 1991 - Chiba University School of Medicine
Professional career (1)：
  • 博士(医学) (千葉大学)
Work history (12)：
  • 2022/10 - 現在 Hokkaido University Vaccine Development Center Professor
  • 2020 - 現在 テキサスA&M大学 Health Science Center (Adjunct Professor) 兼任
  • 2017 - 現在 Hokkaido Unviersity School of Medicine, Professor
  • 2017 - 2020 テキサスA&M大学 Health Science Center, Research Professor
  • 2012 - 2017 Texas A&M University School of Medicine, Professor
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Awards (9)：
  • 2022 - Hokkaido University, Faculty of Medicine Excellent Research Award
  • 2018 - 武田科学振興財団 武田報彰研究助成
  • 2009 - Haartman Seminar, Haartman Institute, University of Helsinki
  • 2006/10 - Cancer Research Institute Investigator Award
  • 2005 - The Claudia Adams Barr Investigator
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Association Membership(s) (7)：
Texas A&M Immunology Consortirum ,  American Society for Biochemistry and Molecular Biology ,  American Association of Advanced Science ,  American Association of Immunologists ,  北海道医学会 ,  日本ウイルス学会 ,  日本免疫学会
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